Engineering Approaches in Human Gamma Delta T Cells for Cancer Immunotherapy

Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation

(2018) Anna Capsomidis et al.   MOLECULAR THERAPY

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrating Vectors for Gene Therapy and Clonal Tracking of Engineered Hematopoiesis

(2017) Luca Biasco et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II–Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3

(2017) Yong-Chen Lu et al.   JOURNAL OF CLINICAL ONCOLOGY

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

(2017) Daniel T. MacLeod et al.   MOLECULAR THERAPY

Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor

(2017) Jonathan Fisher et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

(2017) Zachary B. Davis et al.   SEMINARS IN IMMUNOLOGY

E. coli promotes human Vγ9Vδ2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner

(2017) M. Barisa et al.   Scientific Reports

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

(2017) Myriam Lawand et al.   Frontiers in Immunology

Global Manufacturing of CAR T Cell Therapy

(2017) Bruce L. Levine et al.   Molecular Therapy-Methods & Clinical Development

Optimizing T-cell receptor gene therapy for hematologic malignancies

(2016) Emma C. Morris et al.   BLOOD

A promising sword of tomorrow: Human γδ T cell strategies reconcile allo-HSCT complications

(2016) Yongxian Hu et al.   BLOOD REVIEWS

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

Driving gene-engineered T cell immunotherapy of cancer

(2016) Laura A Johnson et al.   CELL RESEARCH

Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells

(2016) Loretta Gammaitoni et al.   CLINICAL CANCER RESEARCH

The urgent need to recover MHC class I in cancers for effective immunotherapy

(2016) Federico Garrido et al.   CURRENT OPINION IN IMMUNOLOGY

CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo

(2016) Gengwen Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of NG2 Proteoglycan in Glioma

(2016) Sridevi Yadavilli et al.   Translational Oncology

Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies

(2016) Marco Ruella et al.   Computational and Structural Biotechnology Journal

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

Evolution and function of the TCR Vgamma9 chain repertoire: It’s good to be public

(2015) C. David Pauza et al.   CELLULAR IMMUNOLOGY

Untouched GMP-Ready Purified Engineered Immune Cells to Treat Cancer

(2015) T. Straetemans et al.   CLINICAL CANCER RESEARCH

Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor

(2015) James N. Kochenderfer et al.   JOURNAL OF CLINICAL ONCOLOGY

T-cell receptor gene therapy - ready to go viral?

(2015) Terhi Karpanen et al.   Molecular Oncology

Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor

(2015) Kurt Schönfeld et al.   MOLECULAR THERAPY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells

(2015) Kanako Shimizu et al.   PLoS One

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

(2015) Tanya Dimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells

(2015) Jonathan P H Fisher et al.   OncoImmunology

Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies

(2014) D. C. Deniger et al.   CLINICAL CANCER RESEARCH

Neuroblastoma Killing Properties of V 2 and V 2-Negative   T Cells Following Expansion by Artificial Antigen-Presenting Cells

(2014) J. P. H. Fisher et al.   CLINICAL CANCER RESEARCH

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer

(2014) B Berdien et al.   GENE THERAPY

Origins of γδ T Cell Effector Subsets: A Riddle Wrapped in an Enigma

(2014) Shawn P. Fahl et al.   JOURNAL OF IMMUNOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Adenovirus-Specific γ/δ and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation

(2014) Jan Dörrie et al.   PLoS One

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

γδ T cells for cancer immunotherapy

(2014) Jonathan PH Fisher et al.   OncoImmunology

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

NK cell-based immunotherapy for malignant diseases

(2013) Min Cheng et al.   Cellular & Molecular Immunology

Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor

(2013) Drew C Deniger et al.   MOLECULAR THERAPY

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Engineered Drug Resistant γδ T Cells Kill Glioblastoma Cell Lines during a Chemotherapy Challenge: A Strategy for Combining Chemo- and Immunotherapy

(2013) Lawrence S. Lamb et al.   PLoS One

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

(2013) G. L. Beatty et al.   Cancer Immunology Research

 9 and  2CDR3 domains regulate functional avidity of T cells harboring  9 2TCRs

(2012) C. Grunder et al.   BLOOD

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

(2012) B. G. Till et al.   BLOOD

The ganglioside antigen GD2 is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting

(2012) S Kailayangiri et al.   BRITISH JOURNAL OF CANCER

Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside

(2012) Mounia S. Braza et al.   BRITISH JOURNAL OF HAEMATOLOGY

Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI

(2012) Gabrielle M. Siegers et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

What lessons can be learned from γδ T cell-based cancer immunotherapy trials?

(2012) Jean-Jacques Fournié et al.   Cellular & Molecular Immunology

In Vivo Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Trigger V 9V 2 T-cell Antitumor Cytotoxicity through ICAM-1 Engagement

(2012) I. Benzaid et al.   CLINICAL CANCER RESEARCH

The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR

(2012) Li Bai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human V 9V 2 T Cells Specifically Recognize and Kill Acute Myeloid Leukemic Blasts

(2012) J. Gertner-Dardenne et al.   JOURNAL OF IMMUNOLOGY

Human    T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells

(2012) N. Himoudi et al.   JOURNAL OF IMMUNOLOGY

Tumor PD-L1 co-stimulates primary human CD8+ cytotoxic T cells modified to express a PD1:CD28 chimeric receptor

(2012) Megan E. Prosser et al.   MOLECULAR IMMUNOLOGY

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

(2012) Christopher C Kloss et al.   NATURE BIOTECHNOLOGY

Licensing of γδT cells for professional antigen presentation

(2012) John Anderson et al.   OncoImmunology

Genetic engineering with T cell receptors

(2011) Ling Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Redirecting   T cells against cancer cells by transfer of a broadly tumor-reactive   T-cell receptor

(2011) V. Marcu-Malina et al.   BLOOD

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies

(2011) H. Singh et al.   CANCER RESEARCH

γδ T-APCs: a novel tool for immunotherapy?

(2011) Bernhard Moser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells

(2011) Gabrielle M. Siegers et al.   CYTOTHERAPY

The Sleeping Beauty transposon system: a non-viral vector for gene therapy

(2011) E. L. Aronovich et al.   HUMAN MOLECULAR GENETICS

NK cells engineered to express a GD2-specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin

(2011) Ruth Esser et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

(2010) J. N. Kochenderfer et al.   BLOOD

Aminobisphosphonate-pretreated dendritic cells trigger successful Vγ9Vδ2 T cell amplification for immunotherapy in advanced cancer patients

(2010) Florian Cabillic et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Development of Human Anti-Murine T-Cell Receptor Antibodies in Both Responding and Nonresponding Patients Enrolled in TCR Gene Therapy Trials

(2010) J. L. Davis et al.   CLINICAL CANCER RESEARCH

NKG2D Costimulates Human V 9V 2 T Cell Antitumor Cytotoxicity through Protein Kinase C -Dependent Modulation of Early TCR-Induced Calcium and Transduction Signals

(2010) S. Nedellec et al.   JOURNAL OF IMMUNOLOGY

F1-Adenosine Triphosphatase Displays Properties Characteristic of an Antigen Presentation Molecule for V 9V 2 T Cells

(2010) J. Mookerjee-Basu et al.   JOURNAL OF IMMUNOLOGY

CSPG4 Protein as a New Target for the Antibody-Based Immunotherapy of Triple-Negative Breast Cancer

(2010) Xinhui Wang et al.   JNCI-Journal of the National Cancer Institute

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies

(2009) J. Gertner-Dardenne et al.   BLOOD

γδ T Cells and the Lymphoid Stress-Surveillance Response

(2009) Adrian C. Hayday   IMMUNITY

Transfection with mRNA for CD19 specific chimeric antigen receptor restores NK cell mediated killing of CLL cells

(2009) Laurent Boissel et al.   LEUKEMIA RESEARCH

Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells

(2009) Marita Bosticardo et al.   MOLECULAR THERAPY