Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells

ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis

(2018) Vincent Panneton et al.   JOURNAL OF IMMUNOLOGY

Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

(2016) Kelli P. A. MacDonald et al.   BLOOD

Classification systems for chronic graft-versus-host disease

(2016) Stephanie J. Lee   BLOOD

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

ICOS Co-Stimulation: Friend or Foe?

(2016) Daniel J. Wikenheiser et al.   Frontiers in Immunology

CD8+ Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4+ Tregs in mice

(2016) Jessica Heinrichs et al.   OncoImmunology

B Cells in Chronic Graft-versus-Host Disease

(2015) Stefanie Sarantopoulos et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant Research

(2015) Sally Arai et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2

(2015) Jan P. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice

(2015) Steven D. Schutt et al.   PLoS One

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

How we treat chronic graft-versus-host disease

(2014) M. E. D. Flowers et al.   BLOOD

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

(2014) R. Flynn et al.   BLOOD

Once a Treg, always a Treg?

(2014) Deepali V. Sawant et al.   IMMUNOLOGICAL REVIEWS

ICOS controls the pool size of effector-memory and regulatory T cells

(2014) Y. Burmeister et al.   JOURNAL OF IMMUNOLOGY

CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells

(2014) F. Guo et al.   JOURNAL OF IMMUNOLOGY

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells

(2014) Jianmei W Leavenworth et al.   NATURE IMMUNOLOGY

Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease

(2013) M.-C. Bruggen et al.   BLOOD

ICOS controls Foxp3+regulatory T-cell expansion, maintenance and IL-10 production during helminth infection

(2013) Stephen A. Redpath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fluctuations in pathogenic CD4+ T-cell subsets in a murine sclerodermatous model of chronic graft-versus-host disease

(2013) Ji-Young Lim et al.   IMMUNOLOGICAL INVESTIGATIONS

Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells

(2013) T. Wu et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21 Is a Critical Cytokine for the Generation of Virus-Specific Long-Lived Plasma Cells

(2013) M. A. U. Rasheed et al.   JOURNAL OF VIROLOGY

B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

(2012) J. L. Allen et al.   BLOOD

IL-21 Promotes Lupus-like Disease in Chronic Graft-versus-Host Disease through Both CD4 T Cell- and B Cell-Intrinsic Mechanisms

(2012) V. Nguyen et al.   JOURNAL OF IMMUNOLOGY

Murine Regulatory T Cells Contain Hyperproliferative and Death-Prone Subsets with Differential ICOS Expression

(2012) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Donor B Cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4+ T Cells That Mediate Autoimmune-like Chronic Graft-versus-Host Disease

(2012) J. S. Young et al.   JOURNAL OF IMMUNOLOGY

ICOS-Dependent Homeostasis and Function of Foxp3+ Regulatory T Cells in Islets of Nonobese Diabetic Mice

(2012) M. Kornete et al.   JOURNAL OF IMMUNOLOGY

Anti-Chlamydial Th17 Responses Are Controlled by the Inducible Costimulator Partially through Phosphoinositide 3-Kinase Signaling

(2012) Xiaoling Gao et al.   PLoS One

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's Oncology Group Study ASCT0031

(2011) Jacob Rozmus et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Activation and Expansion of CD8+ T Effector Cells in Patients with Chronic Graft-versus-Host Disease

(2011) Bryan M. Grogan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Roles of CD28, CTLA4, and Inducible Costimulator in Acute Graft-versus-Host Disease in Mice

(2011) Jun Li et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells

(2011) K. W. Juchem et al.   BLOOD

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells

(2010) Federico Simonetta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells

(2010) C. M. Paulos et al.   Science Translational Medicine

Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients

(2009) N. Takahashi et al.   JOURNAL OF IMMUNOLOGY

ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10−/− mice

(2009) Jeremy S. Schaefer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY