Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice

Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions

(2014) M. Levade et al.   BLOOD

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

(2014) R. Flynn et al.   BLOOD

Increased BCR responsiveness in B cells from patients with chronic GVHD

(2014) Jessica L. Allen et al.   BLOOD

Current issues in chronic graft-versus-host disease

(2014) G. Socie et al.   BLOOD

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

(2014) Jason A. Dubovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia

(2014) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease

(2013) D. Le Huu et al.   BLOOD

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

(2013) J. A. Dubovsky et al.   BLOOD

c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice

(2013) Yu Yu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells

(2013) T. Wu et al.   JOURNAL OF IMMUNOLOGY

Brutonˈs tyrosine kinase-an integral protein of B cell development that also has an essential role in the innate immune system

(2013) Gabriela López-Herrera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD28 and ITK signals regulate autoreactive T cell trafficking

(2013) Nitya Jain et al.   NATURE MEDICINE

Donor B Cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4+ T Cells That Mediate Autoimmune-like Chronic Graft-versus-Host Disease

(2012) J. S. Young et al.   JOURNAL OF IMMUNOLOGY

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR t in mice

(2011) Y. Yu et al.   BLOOD

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

(2011) M. Srinivasan et al.   BLOOD

Mouse models of graft-versus-host disease: advances and limitations

(2011) M. A. Schroeder et al.   Disease Models & Mechanisms

Alloimmune Response Results in Expansion of Autoreactive Donor CD4+ T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease

(2010) D. Zhao et al.   JOURNAL OF IMMUNOLOGY

Control of α4β7 Integrin Expression and CD4 T Cell Homing by the β1 Integrin Subunit

(2010) Christopher C. DeNucci et al.   JOURNAL OF IMMUNOLOGY

PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

(2009) Javier O. Valenzuela et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine Models of Chronic Graft-versus-Host Disease: Insights and Unresolved Issues

(2008) Yu-Waye Chu et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

B-cell involvement in chronic graft-versus-host disease

(2008) R. Kapur et al.   HAEMATOLOGICA

2 integrins separate graft-versus-host disease and graft-versus-leukemia effects

(2007) Y. Liang et al.   BLOOD