Bone Marrow Adipose Tissue and Skeletal Health

Molecular determinants of acidic pH-dependent transport of human equilibrative nucleoside transporter 3

(2017) Md Fazlur Rahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment Sequence Matters: Anabolic and Antiresorptive Therapy for Osteoporosis

(2017) Felicia Cosman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid hormone regulates fates of murine osteoblast precursors in vivo

(2017) Deepak H. Balani et al.   JOURNAL OF CLINICAL INVESTIGATION

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

(2017) Abbas Jafari et al.   Stem Cell Reports

Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species

(2016) L. Rebiger et al.   BIOSCIENCE REPORTS

Influences of teriparatide administration on marrow fat content in postmenopausal osteopenic women using MR spectroscopy

(2016) Y. Yang et al.   CLIMACTERIC

Neuropeptide Y mediates glucocorticoid-induced osteoporosis and marrow adiposity in mice

(2016) F.-S. Wang et al.   OSTEOPOROSIS INTERNATIONAL

Meteorin-Like Shows Unique Expression Pattern in Bone and Its Overexpression Inhibits Osteoblast Differentiation

(2016) Weiyan Gong et al.   PLoS One

Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation

(2016) Shanmugam Muruganandan et al.   STEM CELLS

Lack of the nucleoside transporter ENT1 results in the Augustine-null blood type and ectopic mineralization

(2015) G. Daniels et al.   BLOOD

CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo

(2015) Ju-Young Kim et al.   BONE

MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation

(2015) Jih-Yang Ko et al.   BONE

Antiresorptives and anabolic therapy in sequence or combination for postmenopausal osteoporosis

(2015) S. Palacios et al.   CLIMACTERIC

Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2

(2015) Aránzazu Mediero et al.   FASEB JOURNAL

Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats

(2015) Chiaming Fan et al.   JOURNAL OF BONE AND MINERAL METABOLISM

The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians

(2015) Julien Paccou et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study

(2015) S. Papapoulos et al.   OSTEOPOROSIS INTERNATIONAL

Bone mineral density and inflammatory and bone biomarkers after darunavir–ritonavir combined with either raltegravir or tenofovir–emtricitabine in antiretroviral-naive adults with HIV-1: a substudy of the NEAT001/ANRS143 randomised trial

(2015) Jose I Bernardino et al.   Lancet HIV

The role of purinergic receptors in stem cell differentiation

(2015) Constanze Kaebisch et al.   Computational and Structural Biotechnology Journal

Risk of fracture with thiazolidinediones: An updated meta-analysis of randomized clinical trials

(2014) Zhong-Ning Zhu et al.   BONE

Subfatin is a Novel Adipokine and Unlike Meteorin in Adipose and Brain Expression

(2014) Zhi-Yong Li et al.   CNS Neuroscience & Therapeutics

Influence of Early Zoledronic Acid Administration on Bone Marrow Fat in Ovariectomized Rats

(2014) Guan-Wu Li et al.   ENDOCRINOLOGY

The impact of bone marrow adipocytes on osteoblast and osteoclast differentiation

(2014) Shanmugam Muruganandan et al.   IUBMB LIFE

Aberrant Bone Density in Aging Mice Lacking the Adenosine Transporter ENT1

(2014) David J. Hinton et al.   PLoS One

Anabolic and Antiresorptive Therapy for Osteoporosis: Combination and Sequential Approaches

(2014) Felicia Cosman   Current Osteoporosis Reports

Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications

(2014) Meghan A Piccinin et al.   Adipocyte

TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells

(2013) Shoichiro Kokabu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rolofylline, an adenosine A1receptor antagonist, inhibits osteoclast differentiation as an inverse agonist

(2013) Wenjie He et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antidiabetic therapy effects on bone metabolism and fracture risk

(2013) A. Montagnani et al.   DIABETES OBESITY & METABOLISM

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

Molecular and functional characterization of human bone marrow adipocytes

(2013) Antonella Poloni et al.   EXPERIMENTAL HEMATOLOGY

Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma

(2013) Wenjie He et al.   FASEB JOURNAL

Marrow Fat and Bone—New Perspectives

(2013) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New insights into osteoporosis: the bone-fat connection

(2013) M. Kawai et al.   JOURNAL OF INTERNAL MEDICINE

Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis

(2013) Shanmugam Muruganandan et al.   STEM CELLS

Osteoblast-Targeted suppression of PPARγ increases osteogenesis through activation of mTOR signaling

(2013) Hongli Sun et al.   STEM CELLS

Adenosine and bone metabolism

(2013) Aránzazu Mediero et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The sixth sense: hematopoietic stem cells detect danger through purinergic signaling

(2012) L. Rossi et al.   BLOOD

Failure to generate bone marrow adipocytes does not protect mice from ovariectomy-induced osteopenia

(2012) Urszula T. Iwaniec et al.   BONE

Insulin-Like Growth Factor 1 Physiology

(2012) Shoshana Yakar et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Pioglitazone increases bone marrow fat in type 2 diabetes: results from a randomized controlled trial

(2012) Andrew Grey et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Whole-exome sequencing identifies mutations in the nucleoside transporter gene SLC29A3 in dysosteosclerosis, a form of osteopetrosis

(2012) P. M. Campeau et al.   HUMAN MOLECULAR GENETICS

Rosiglitazone Ameliorates Diabetic Nephropathy by Reducing the Expression of Chemerin and ChemR23 in the Kidney of Streptozotocin-Induced Diabetic Rats

(2012) Wenchao Hu et al.   INFLAMMATION

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa

(2012) Pouneh K Fazeli et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans

(2012) Sumeeta Warraich et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Extracellular Purines Promote the Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells to the Osteogenic and Adipogenic Lineages

(2012) Marilena Ciciarello et al.   STEM CELLS AND DEVELOPMENT

Adenosine A2A Receptor Ligation Inhibits Osteoclast Formation

(2011) Aránzazu Mediero et al.   AMERICAN JOURNAL OF PATHOLOGY

New factors controlling the balance between osteoblastogenesis and adipogenesis

(2011) Basem M. Abdallah et al.   BONE

Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes

(2011) A. Krings et al.   BONE

TLE3 Is a Dual-Function Transcriptional Coregulator of Adipogenesis

(2011) Claudio J. Villanueva et al.   Cell Metabolism

Purinergic signaling in embryonic and stem cell development

(2011) Geoffrey Burnstock et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations

(2011) Hanna Taipaleenmäki et al.   EXPERIMENTAL CELL RESEARCH

Contrasting effects of A1 and A2b adenosine receptors on adipogenesis

(2011) B Gharibi et al.   INTERNATIONAL JOURNAL OF OBESITY

Chemerin, a Novel Peroxisome Proliferator-activated Receptor γ (PPARγ) Target Gene That Promotes Mesenchymal Stem Cell Adipogenesis

(2011) Shanmugam Muruganandan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes

(2011) Borzo Gharibi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CD73-generated adenosine promotes osteoblast differentiation

(2011) Masahide Takedachi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

From bone biology to clinical outcome: state of the art and future perspectives

(2010) G. Schett et al.   ANNALS OF THE RHEUMATIC DISEASES

Adenosine A1receptors regulate bone resorption in mice: Adenosine A1receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A1receptor-knockout mice

(2010) Firas M. Kara et al.   ARTHRITIS AND RHEUMATISM

FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice

(2010) Elena Ambrogini et al.   Cell Metabolism

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Purinergic stimulation of human mesenchymal stem cells potentiates their chemotactic response to CXCL12 and increases the homing capacity and production of proinflammatory cytokines

(2010) Davide Ferrari et al.   EXPERIMENTAL HEMATOLOGY

Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function

(2010) Firas M. Kara et al.   FASEB JOURNAL

Caloric restriction leads to high marrow adiposity and low bone mass in growing mice

(2010) Maureen J Devlin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice

(2010) Ganesh V. Halade et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of risedronate on bone marrow adipocytes in postmenopausal women

(2010) G. Duque et al.   OSTEOPOROSIS INTERNATIONAL

Regulation of bone development and extracellular matrix protein genes by RUNX2

(2009) Toshihisa Komori   CELL AND TISSUE RESEARCH

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

(2009) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of chemerin/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells

(2009) Shanmugam Muruganandan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased Bone Marrow Fat in Anorexia Nervosa

(2009) Miriam A. Bredella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis

(2009) Ichiro Takada et al.   Nature Reviews Rheumatology

Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: A longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice

(2008) Wei Yao et al.   ARTHRITIS AND RHEUMATISM

Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program

(2008) S. Muruganandan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aromatase inhibitor-associated bone loss in breast cancer patients is distinct from postmenopausal osteoporosis

(2008) Peyman Hadji   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Strain-Specific Effects of Rosiglitazone on Bone Mass, Body Composition, and Serum Insulin-Like Growth Factor-I

(2008) Cheryl L. Ackert-Bicknell et al.   ENDOCRINOLOGY

TNAP, TrAP, ecto-purinergic signaling, and bone remodeling

(2008) Jonathan D. Kaunitz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development

(2008) Majid Katebi et al.   JOURNAL OF LEUKOCYTE BIOLOGY