Article
Immunology
Laura Wiesner, Carla Schmutte, Imke Steffen
Summary: Tick-borne encephalitis virus (TBEV) is a serious pathogen that requires heightened biosafety measures in the laboratory. Different inactivation procedures, such as heat, acidic pH, alcohol, formaldehyde, detergents, and UV irradiation, show varying effectiveness against TBEV, depending on sample size and composition.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Naveed Asghar, Wessam Melik, Katrine M. Paulsen, Bendikte N. Pedersen, Erik G. Bo-Granquist, Rose Vikse, Snorre Stuen, Soren Andersson, Ake Strid, Ashild K. Andreassen, Magnus Johansson
Summary: Flaviviruses pose a threat to public health, with tick-borne encephalitis being one of the major diseases caused by this virus. There is currently no antiviral treatment available, making vaccination the best preventive measure. A study aimed to develop an edible vaccine for tick-borne encephalitis, which would trigger a stronger immune response through oral delivery of viral antigens. However, the edible vaccine candidate did not provide immunity in mice during the challenge with the virus.
Article
Virology
Rebekah J. McMinn, Rose M. Langsjoen, Andrei Bombin, Rebecca M. Robich, Erick Ojeda, Erica Normandin, Heidi K. Goethert, Charles B. Lubelczyk, Elizabeth Schneider, Danielle Cosenza, Molly Meagher, Melissa A. Prusinski, Pardis C. Sabeti, Robert P. Smith, Sam R. Telford III, Anne Piantadosi, Gregory D. Ebel
Summary: The burden of ticks and tick-borne pathogens, including Powassan virus (POWV), is increasing worldwide. In this study, the emergence of deer tick virus (DTV), a lineage of POWV, in North America was evaluated. DTV-positive ticks were found in eight out of twenty locations in the Northeast USA. Whole-genome sequencing and phylodynamic analysis revealed stable infection in the region and geographic dispersal patterns. The analysis also showed DTV population expansion over the past 50 years, indicating an increasing risk of human exposure as the tick vector spreads.
Article
Pharmacology & Pharmacy
Na Li, Cheng-Lin Deng, Qi Li, Xiao-Ling Chen, Bo Zhang, Han-Qing Ye
Summary: High titers of replication-defective ZIKV with NS1 deletion (ZIKV-Delta NS1) were generated using the NS1 transcomplementation system. ZIKV-Delta NS1 vaccine induced antibody responses and provided protection against ZIKV infection in mice. Moreover, ZIKV-Delta NS1 vaccination attenuated vertical transmission during pregnancy. These findings highlight the potential of the NS1 trans-complementation system for developing flavivirus vaccines.
ANTIVIRAL RESEARCH
(2023)
Article
Virology
Ivan S. Kholodilov, Oxana A. Belova, Evgeny S. Morozkin, Alexander G. Litov, Anna Y. Ivannikova, Marat T. Makenov, Alexey M. Shchetinin, Sergey V. Aibulatov, Galina K. Bazarova, Lesley Bell-Sakyi, Liubov A. Bespyatova, Sergey V. Bugmyrin, Nikita Chernetsov, Liubov L. Chernokhaeva, Larissa V. Gmyl, Anna N. Khaisarova, Alexei V. Khalin, Alexander S. Klimentov, Irina V. Kovalchuk, Svetlana V. Luchinina, Sergey G. Medvedev, Alexander A. Nafeev, Natalia D. Oorzhak, Elena V. Panjukova, Alexandra E. Polienko, Kristina A. Purmak, Evgeniya N. Romanenko, Evgeniy N. Rozhdestvenskiy, Anna A. Saryglar, Anton F. Shamsutdinov, Nataliya I. Solomashchenko, Vladimir A. Trifonov, Evgenii G. Volchev, Pavel G. Vovkotech, Alexander S. Yakovlev, Olga B. Zhurenkova, Vladimir A. Gushchin, Lyudmila S. Karan, Galina G. Karganova
Summary: This study detected the presence of Yanggou tick virus in ticks in two neighboring regions of Russia, as well as Alongshan virus in various tick species in eight regions of Russia. The successful replication of these viruses was demonstrated, and phylogenetic analysis showed the division of Alongshan virus into different subgroups based on tick species.
Article
Immunology
Hao-Long Dong, Mei-Juan He, Qing-Yang Wang, Jia-Zhen Cui, Zhi-Li Chen, Xiang-Hua Xiong, Lian-Cheng Zhang, Hao Cheng, Guo-Qing Xiong, Ao Hu, Yuan-Yuan Lu, Chun-Lin Cheng, Zhi-Xin Meng, Chen Zhu, Guang Zhao, Gang Liu, Hui-Peng Chen
Summary: The genus Flavivirus includes important human and animal pathogens. A simple and rapid method called CPER was used to synthesize recombinant flaviviruses in vertebrate and insect cells. This study established a CPER-based recovery system for flaviviruses of different host ranges.
Article
Immunology
Wilson R. Raney, Erik J. Herslebs, Ingeborg M. Langohr, Madeline C. Stone, Meghan E. Hermance
Summary: The invasive Asian longhorned tick, Haemaphysalis longicornis, has been detected in 17 states in North America and shows vector competence for Powassan virus (POWV). This suggests a growing threat to human health in the United States posed by this invasive tick species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephane Fraga de Oliveira Tosta, Mariana Santana Passos, Rodrigo Kato, Alvaro Salgado, Joilson Xavier, Arun Kumar Jaiswal, Siomar C. Soares, Vasco Azevedo, Marta Giovanetti, Sandeep Tiwari, Luiz Carlos Junior Alcantara
Summary: Yellow fever is a re-emerging major health issue causing recent outbreaks with high mortality rates, mainly affecting tropical countries in Africa and South America. The development of a multi-epitope vaccine for Yellow fever virus using immunoinformatics approaches shows potential in stimulating both humoral and cellular immune responses, making it a candidate for further experimental validation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Microbiology
Agathe M. G. Colmant, Remi N. Charrel, Bruno Coutard
Summary: Jingmenviruses, discovered recently, are a group of viruses closely related to flaviviruses, with a segmented genome. They have the potential to cause a pandemic and have been found in various hosts, including insects and vertebrates. Further research is needed to understand their replication process and mechanisms associated with human and animal diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Yuji Takahashi, Shintaro Kobayashi, Ryo Nakao, Hiroaki Kariwa, Kentaro Yoshii
Summary: A novel Far Eastern subtype of tick-borne encephalitis virus was isolated from a dog in central Hokkaido, Japan. The isolated strain showed similar growth properties to known strains, but displayed a different distribution in infected neurons of the mouse brain. This suggests the presence of unknown TBEV strains in other areas of Japan.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Parasitology
Caitlin A. O'Brien, Bixing Huang, David Warrilow, Jessamine E. Hazlewood, Helle Bielefeldt-Ohmann, Sonja Hall-Mendelin, Cassandra L. Pegg, Jessica J. Harrison, Devina Paramitha, Natalee D. Newton, Benjamin L. Schulz, Andreas Suhrbier, Jody Hobson-Peters, Roy A. Hall
Summary: A subset of Australians bitten by ticks experience chronic and debilitating symptoms that cannot be explained by known pathogenic bacteria. In an effort to understand these symptoms, researchers in Australia are identifying and characterising viruses in ticks. This study successfully characterises five tick-borne viruses and provides insights into their replication and antigenic profiles.
PARASITES & VECTORS
(2022)
Article
Immunology
Julia Finkensieper, Leila Issmail, Jasmin Fertey, Alexandra Rockstroh, Simone Schopf, Bastian Standfest, Martin Thoma, Thomas Grunwald, Sebastian Ulbert
Summary: Tick-borne encephalitis virus (TBEV) is a zoonotic flavivirus that can cause severe neurological complications in humans. Traditional methods of producing TBEV vaccines using formaldehyde have drawbacks, and this study suggests that low-energy electron irradiation (LEEI) could be an alternative method. Immunizing mice with LEEI-inactivated TBEV resulted in higher levels of antibodies and complete protection against viral challenge.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Charles Ndawula
Summary: Ticks are blood-sucking ectoparasites capable of transmitting various pathogens, and while the predominant method of control is the use of acaricides, there are concerns over resistance and residue accumulation. Anti-tick cattle vaccination is seen as a sustainable alternative, but often shows lower efficacy compared to the Bm86-based vaccines. Current approaches to assess vaccine effectiveness and potential bottlenecks are examined in this review, along with a proposed model to aid in the assessment process.
Article
Immunology
Danielle L. Porier, Sarah N. Wilson, Dawn I. Auguste, Andrew Leber, Sheryl Coutermarsh-Ott, Irving C. Allen, Clayton C. Caswell, James A. Budnick, Josep Bassaganya-Riera, Raquel Hontecillas, James Weger-Lucarelli, Scott C. Weaver, Albert J. Auguste
Summary: Using insect-specific flavivirus as a vector for vaccine development can create safe and effective vaccines, such as the chimeric vaccine ARPV/ZIKV, which successfully prevented Zika virus transmission. The vaccine showed no pathological effects in mice and induced strong immune responses with just a single dose.
Article
Microbiology
Katarina Penazziova, Lubos Korytar, Ivana Cingelova Maruscakova, Petra Schusterova, Alexander Loziak, Sona Pivka, Anna Ondrejkova, Juraj Pistl, Tomas Csank
Summary: This study reports a serosurvey on tick-borne encephalitis virus, Kemerovo orbivirus, and Tribec orbivirus infections in tick-infested and non-infested birds. The results indicate an increased prevalence of tick-borne encephalitis virus and Tribec orbivirus in birds over the past few years. This is the first study on Kemerovo orbivirus infection in the Slovak bird population, suggesting its occurrence in a new geographic area. The findings highlight the importance of tick infestation rates, seropositivity, and specific neutralizing antibody titers.
Article
Microbiology
Luwanika Mlera, Danielle K. Offerdahl, Craig Martens, Stephen F. Porcella, Wessam Melik, Marshall E. Bloom
Article
Virology
Luwanika Mlera, Wessam Melik, Danielle K. Offerdahl, Eric Dahlstrom, Stephen F. Porcella, Marshall E. Bloom
Article
Microbiology
Luwanika Mlera, Jennifer Lam, Danielle K. Offerdahl, Craig Martens, Daniel Sturdevant, Charles V. Turner, Stephen F. Porcella, Marshall E. Bloom
Article
Virology
Danielle K. Offerdahl, David W. Dorward, Bryan T. Hansen, Marshall E. Bloom
Article
Microbiology
Jeffrey M. Grabowski, Konstantin A. Tsetsarkin, Dan Long, Dana P. Scott, Rebecca Rosenke, Tom G. Schwan, Luwanika Mlera, Danielle K. Offerdahl, Alexander G. Pletnev, Marshall E. Bloom
Review
Virology
Eliza M. Kellman, Danielle K. Offerdahl, Wessam Melik, Marshall E. Bloom
Article
Biochemistry & Molecular Biology
Karen E. Marshall, Danielle K. Offerdahl, Jonathan O. Speare, David W. Dorward, Aaron Hasenkrug, Aaron B. Carmody, Gerald S. Baron
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Virology
Gregory J. Raymond, Brent Race, Jason R. Hollister, Danielle K. Offerdahl, Roger A. Moore, Ravindra Kodali, Lynne D. Raymond, Andrew G. Hughson, Rebecca Rosenke, Dan Long, David W. Dorward, Gerald S. Baron
JOURNAL OF VIROLOGY
(2012)
Article
Microbiology
Jeffrey M. Grabowski, Olof R. Nilsson, Elizabeth R. Fischer, Dan Long, Danielle K. Offerdahl, Yoonseong Park, Dana P. Scott, Marshall E. Bloom
Article
Virology
Tyler G. Lewy, Danielle K. Offerdahl, Jeffrey M. Grabowski, Eliza Kellman, Luwanika Mlera, Abhilash Chiramel, Marshall E. Bloom
Article
Virology
Joshua M. Kirsch, Luwanika Mlera, Danielle K. Offerdahl, Marthe VanSickle, Marshall E. Bloom
Article
Virology
Stacey L. P. Scroggs, Danielle K. Offerdahl, Dylan P. Flather, Ciera N. Morris, Benjamin L. Kendall, Rebecca M. Broeckel, Paul A. Beare, Marshall E. Bloom
Summary: The study found that fluoroquinolones at high concentrations have some inhibitory effects on the replication of SARS-CoV-2 and MERS-CoV, with enoxacin showing the best results. Levofloxacin did not exhibit cellular toxicity in any cell type, while moxifloxacin showed toxicity at high concentrations in both cell types.
Article
Immunology
Luwanika Mlera, Danielle K. Offerdahl, David W. Dorward, Aaron Carmody, Abhilash Chiramel, Sonja M. Best, Marshall E. Bloom
Summary: The study found that the LXR agonist can inhibit flavivirus and Zika virus infection by increasing the expression of cellular antiviral factors, disrupting the replication process of the viruses.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Biotechnology & Applied Microbiology
Danielle K. Offerdahl, Niall G. Clancy, Marshall E. Bloom
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2016)