Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis

A murine model of type 2 diabetes mellitus developed using a combination of high fat diet and multiple low doses of streptozotocin treatment mimics the metabolic characteristics of type 2 diabetes mellitus in humans

(2017) Sayantan Nath et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Random non-fasting C-peptide: bringing robust assessment of endogenous insulin secretion to the clinic

(2016) S. V. Hope et al.   DIABETIC MEDICINE

Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations

(2016) Jingya Qiu et al.   GENETIC EPIDEMIOLOGY

Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed by gambogic acid independently of HIF-1α

(2016) Wei Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A long-term high-fat, high-sucrose diet in Bama minipigs promotes lipid deposition and amyotrophy by up-regulating the myostatin pathway

(2016) Jinxue Ruan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes

(2016) Kesong Peng et al.   Scientific Reports

Cardiovascular manifestations of renovascular hypertension in diabetic mice

(2016) Sonu Kashyap et al.   PeerJ

Multi-transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis

(2015) SIYUAN KONG et al.   Molecular Medicine Reports

Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs

(2015) Shu-lin Yang et al.   Scientific Reports

Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells

(2015) Biagio Arcidiacono et al.   Frontiers in Endocrinology

Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs

(2015) Jihan Xia et al.   PLoS One

A Long-Term High-Fat/High-Sucrose Diet Promotes Kidney Lipid Deposition and Causes Apoptosis and Glomerular Hypertrophy in Bama Minipigs

(2015) Li Li et al.   PLoS One

Molecular cloning and characterization of the promoter region of the porcine apolipoprotein E gene

(2014) Jihan Xia et al.   MOLECULAR BIOLOGY REPORTS

Metastasis-Associated in Colon Cancer 1 Is a Novel Survival-Related Biomarker for Human Patients with Renal Pelvis Carcinoma

(2014) Hailong Hu et al.   PLoS One

 -Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

(2013) S. Costes et al.   DIABETES

11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus

(2012) C. D. Pereira et al.   DIABETES OBESITY & METABOLISM

Use of mouse models in studying type 2 diabetes mellitus

(2011) Angela W.S. Lee et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role inβ-Cell Death in Type 2 Diabetes Mellitus

(2008) Lucie Khemtémourian et al.   Experimental Diabetes Research