Article
Toxicology
Zhi Huang, Meng Zhang, Dongling He, Pengshu Song, Caifeng Mo, Xiaoyang Cheng, Tianlin Song, Yalan Li, Xuerong Zhang, Ming Liao
Summary: The study established an animal model of Bungarus multicinctus bite and identified the links between metabolic perturbations, pathophysiology, and potential diagnostic biomarkers of Bungarus multicinctus bite, providing valuable insights for studying the mechanism of Bungarus multicinctus bite.
TOXICOLOGY LETTERS
(2021)
Article
Veterinary Sciences
Baoyuan Liu, Yiyang Chen, Meimei Zhang, Tianxiang Chen, Yuan Zhang, DanBaZha Xi, Shixuan Xu, Qin Zhao, En-Min Zhou
Summary: This study confirms the presence of HEV infection in laboratory Bama miniature pigs in China and demonstrates that these pigs can be experimentally infected with HEV. Screening of laboratory pigs for HEV is important to prevent zoonotic infections.
BMC VETERINARY RESEARCH
(2022)
Article
Microbiology
Jia Wang, Lizhong Hua, Yuan Gan, Ting Yuan, Long Li, Yanfei Yu, Qingyun Xie, Ademola O. Olanarin, Thamsanqa E. Chiliza, Guoqing Shao, Zhixin Feng, Bala Pillay, Qiyan Xiong
Summary: Mycoplasma hyorhinis is a prevalent pathogen in pig farms globally. This study aimed to evaluate the impact of strain virulence and inoculation route on the consequences of M. hyorhinis infection. Pigs inoculated with the CO strain through IV+IP route showed severe diseases such as joint swelling and lameness. In contrast, pigs inoculated with the NCO strain and through IN route exhibited milder symptoms.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemical Research Methods
Li-Fei Wu, De-Ping Wang, Jing Shen, Li-Juan Gao, Ying Zhou, Qing-Hua Liu, Ji-Min Cao
Summary: Lysine malonylation plays an important role in cardiac remodeling, particularly in relation to isocitrate dehydrogenase 2 (IDH2).
JOURNAL OF PROTEOMICS
(2022)
Article
Materials Science, Biomaterials
Langfan Qu, Zelin Chen, Jianhua Chen, Yibo Gan, Xu Tan, Yu Wang, Can Zhang, Bing Chen, Jianwu Dai, Jianxin Chen, Chunmeng Shi
Summary: The use of traditional materials has limited the regenerative repair of abdominal wall defects, but biomaterials with high biocompatibility and low immunogenicity show potential in regenerating abdominal muscle tissue. Experiments on Bama miniature pigs showed that unmodified collagen biomaterials are a better option for repairing abdominal wall defects, while CBD-bFGF modified collagen biomaterials failed to induce regenerative repair.
BIOMATERIALS SCIENCE
(2023)
Article
Veterinary Sciences
Jiayuan Mo, Yujie Lu, Tianqi Xing, Di Xu, Kun Zhang, Shuai Zhang, Yubin Wang, Gang Yan, Ganqiu Lan, Jing Liang
Summary: The metabolic and physiological profiles of Bama miniature pigs aged between 6 and 12 months remain unclear. This study aimed to identify the differences in blood metabolites and physiological features in different age groups. The results suggest that 12-month-old Bama miniature pigs have higher levels of MID cell ratio, red blood count, and amino acids, making them more suitable as a medical model organism for human development.
PORCINE HEALTH MANAGEMENT
(2022)
Article
Genetics & Heredity
Nicolas Garrido, Andre Albuquerque, Rui Charneca, Filipa Costa, Carla Marmelo, Amelia Ramos, Luisa Martin, Jose Manuel Martins
Summary: This study investigated the backfat transcriptome of surgically castrated, intact, and intact fed an experimental diet outdoor-reared male Alentejano pigs. Significant differences were observed between intact and castrated pigs, with differentially expressed genes related to muscular activity or collagen metabolism. In contrast, the effect of the experimental diet was marginal. The results indicate that the testis plays a significant role in the transcriptome of subcutaneous fat in these pigs.
Review
Biochemistry & Molecular Biology
Le Wang, Shengshou Hu, Bingying Zhou
Summary: Single-cell RNA sequencing allows for comprehensive characterization of heart cells, leading to a transformation in our understanding of their diversity and dynamics.
Article
Agriculture, Dairy & Animal Science
Zhaoming Yan, Yinzhao Zhong, Yunju Yin, Yehui Duan, Wenlong Wang, Lingyu Zhang, Qiuping Guo, Qinghua Chen, Fengna Li
Summary: This study investigated the effects of supplementing different levels of tea powder in diets on pig growth performance, meat quality, and antioxidant properties. The results showed that supplementation of tea powder did not affect the growth performance of pigs, but improved carcass traits and meat quality. Additional research is needed to further understand the full potential of tea powder as a dietary supplement in animal husbandry.
Article
Veterinary Sciences
Aziz Ullah Noor, Zhanyu Du, Huipeng Lu, Xiaohui Zhou, Xiaoming Liu, Jingjing Xiao, Xinyu Zhang, Huaichang Sun
Summary: The study cloned the PoIFN-alpha omega cDNA from Chinese Bama miniature pigs, showing good antiviral activity against four different pig viruses, suggesting its potential use as an antiviral agent. Additionally, while the PoIFN-alpha omega sequence was identical between different pig species, significant differences were found in their tissue expression profiles.
VETERINARY RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Jian Feng, Song Wang, Kai Jiang
Summary: This study aimed to investigate the influence of the heat irrigating effect of radiofrequency ablation (RFA) on regional liver tissue in Bama miniature pigs. The results showed that thermal damage changes occur in liver tissue around the ablated portal vein and its distal area when the RFA electrode tip is close to (<5mm) the portal vein.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Eric Simon, Maciej Motyka, Grietje H. Prins, Mei Li, Werner Rust, Stefan Kauschke, Coralie Viollet, Peter Olinga, Anouk Oldenburger
Summary: There is a need for predictive ex vivo models for NAFLD. This study profiles a new human and mouse PCLSs based assay for steatosis in NAFLD using RNASeq. Steatosis is induced by incremental supplementation of sugars, insulin, and fatty acids, and the gene expression regulation is analyzed across different nutrient conditions and time for both human and mouse liver organ derived PCLSs.
Article
Agriculture, Dairy & Animal Science
Z. Cheng, A. Wylie, C. Ferris, K. L. Ingvartsen, D. C. Wathes
Summary: Elevated circulating NEFA concentrations were associated with changes in immune system processes in early lactation cows, while different diets did not significantly impact gene expression.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Hongyu Wang, Pengke Xia, Zhiyang Lu, Yong Su, Weiyun Zhu
Summary: Time-restricted feeding (TRF) can effectively regulate metabolism and health, and its effects on hypothalamic function were investigated in this study. The results showed that TRF altered the activities of digestive enzymes and gastrointestinal hormones. In addition, TRF affected the metabolism of aromatic amino acids and modulated the gene expression in the hypothalamus. These findings suggest that TRF improves nutrient digestion and absorption, and may influence hypothalamic functions, including drug addictions.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Multidisciplinary Sciences
Leroy C. Joseph, Jianting Shi, Quynh N. Nguyen, Victoria Pensiero, Chris Goulbourne, Robert C. Bauer, Hanrui Zhang, John P. Morrow
Summary: This study examines the response of the heart to a high-fat diet at the metabolomic and transcriptomic levels, revealing significant sex differences in cardiac metabolites and gene expression.
Article
Biochemistry & Molecular Biology
Z. Z. Liu, J. H. Xia, L. L. Xin, Z. G. Wang, L. Qian, S. G. Wu, S. L. Yang, K. Li
GENETICS AND MOLECULAR RESEARCH
(2015)
Article
Oncology
Siyuan Kong, Jinxue Ruan, Leilei Xin, Junhua Fan, Jihan Xia, Zhiguo Liu, Yulian Mu, Shulin Yang, Kui Li
MOLECULAR MEDICINE REPORTS
(2016)
Article
Gastroenterology & Hepatology
Zhan-zhao Zhao, Lei-lei Xin, Ji-han Xia, Shu-lin Yang, Yao-xing Chen, Kui Li
Article
Cell Biology
Jinxue Ruan, Yuanyuan Zhang, Jing Yuan, Leilei Xin, Jihan Xia, Nan Liu, Yulian Mu, Yaoxing Chen, Shulin Yang, Kui Li
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Oncology
Chenxiao Li, Jihan Xia, Wenjuan Zhu, Leilei Xin, Cuiping An, Shulin Yang, Kui Li
MOLECULAR MEDICINE REPORTS
(2017)
Article
Multidisciplinary Sciences
Yang Chen, Qin Zhang, Qiuyan Wang, Jie Li, Csilla Sipeky, Jihan Xia, Ping Gao, Yanling Hu, Haiying Zhang, Xiaobo Yang, Haitao Chen, Yonghua Jiang, Yuehong Yang, Ziting Yao, Yinchun Chen, Yong Gao, Aihua Tan, Ming Liao, Johanna Schleutker, Jianfeng Xu, Yinghao Sun, Gong-Hong Wei, Zengnan Mo
SCIENTIFIC REPORTS
(2017)
Article
Biology
Tang Hai, Chunwei Cao, Haitao Shang, Weiwei Guo, Yanshuang Mu, Shulin Yang, Ying Zhang, Qiantao Zheng, Tao Zhang, Xianlong Wang, Yu Liu, Qingran Kong, Kui Li, Dayu Wang, Meng Qi, Qianlong Hong, Rui Zhang, Xiupeng Wang, Qitao Jia, Xiao Wang, Guosong Qin, Yongshun Li, Ailing Luo, Weiwu Jin, Jing Yao, Jiaojiao Huang, Hongyong Zhang, Menghua Li, Xiangmo Xie, Xuejuan Zheng, Kenan Guo, Qinghua Wang, Shibin Zhang, Liang Li, Fei Xie, Yu Zhang, Xiaogang Weng, Zhi Yin, Kui Hu, Yimei Cong, Peng Zheng, Hailong Zou, Leilei Xin, Jihan Xia, Jinxue Ruan, Hegang Li, Weiming Zhao, Jing Yuan, Zizhan Liu, Weiwang Gu, Ming Li, Yong Wang, Hongmei Wang, Shiming Yang, Zhonghua Liu, Hong Wei, Jianguo Zhao, Qi Zhou, Anming Meng
Article
Oncology
Bo Zhang, Men-Yun Chen, Yu-Jun Shen, Xian-Bo Zhuo, Ping Gao, Fu-Sheng Zhou, Bo Liang, Jun Zu, Qin Zhang, Sufyan Suleman, Yi-Hui Xu, Min-Gui Xu, Jin-Kai Xu, Chen-Cheng Liu, Nikolaos Giannareas, Ji-Han Xia, Yuan Zhao, Zhong-Lian Huang, Zhen Yang, Huai-Dong Cheng, Na Li, Yan-Yan Hong, Wei Li, Min-Jun Zhang, Ke-Da Yu, Guoliang Li, Meng-Hong Sun, Zhen-Dong Chen, Gong-Hong Wei, Zhi-Min Shao
Article
Biochemistry & Molecular Biology
Ping Gao, Ji-Han Xia, Csilla Sipeky, Xiao-Ming Dong, Qin Zhang, Yuehong Yang, Peng Zhang, Sara Pereira Cruz, Kai Zhang, Jing Zhu, Hang-Mao Lee, Sufyan Suleman, Nikolaos Giannareas, Song Liu, Teuvo L. J. Tammela, Anssi Auvinen, Xiaoyue Wang, Qilai Huang, Liguo Wang, Aki Manninen, Markku H. Vaarala, Liang Wang, Johanna Schleutker, Gong-Hong Wei
Article
Multidisciplinary Sciences
Peng Zhang, Ji-Han Xia, Jing Zhu, Ping Gao, Yi-Jun Tian, Meijun Du, Yong-Chen Guo, Sufyan Suleman, Qin Zhang, Manish Kohli, Lori S. Tillmans, Stephen N. Thibodeau, Amy J. French, James R. Cerhan, Li-Dong Wang, Gong-Hong Wei, Liang Wang
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Jihan Xia, Leilei Xin, Wenjuan Zhu, Li Li, Chenxiao Li, Yanfang Wang, Yulian Mu, Shulin Yang, Kui Li
SCIENTIFIC REPORTS
(2016)
Review
Cell Biology
Ji-Han Xia, Gong-Hong Wei
Article
Multidisciplinary Sciences
Musaddeque Ahmed, Fraser Soares, Ji-Han Xia, Yue Yang, Jing Li, Haiyang Guo, Peiran Su, Yijun Tian, Hyung Joo Lee, Miranda Wang, Nayeema Akhtar, Kathleen E. Houlahan, Almudena Bosch, Stanley Zhou, Parisa Mazrooei, Junjie T. Hua, Sujun Chen, Jessica Petricca, Yong Zeng, Alastair Davies, Michael Fraser, David A. Quigley, Felix Y. Feng, Paul C. Boutros, Mathieu Lupien, Amina Zoubeidi, Liang Wang, Martin J. Walsh, Ting Wang, Shancheng Ren, Gong-Hong Wei, Housheng Hansen He
Summary: Prostate cancer risk-associated SNPs are enriched in noncoding cis-regulatory elements. The authors describe a causal mechanism synergistically driven by a risk SNP and DNA methylation-mediated 3D genome architecture, highlighting the importance of integrating genetics and epigenetics in assessing risks conferred by genetic predispositions.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Kaiyi Zhang, Cong Tao, Jianping Xu, Jinxue Ruan, Jihan Xia, Wenjuan Zhu, Leilei Xin, Huaqiong Ye, Ning Xie, Boce Xia, Chenxiao Li, Tianwen Wu, Yanfang Wang, Martine Schroyen, Xinhua Xiao, Jiangao Fan, Shulin Yang
Summary: This study utilized a transgenic pig model to investigate the impact of three humanized disease risk genes on metabolic disorders and the potential of anti-inflammatory therapy, demonstrating increased risk of metabolic disorders and early symptoms of type 2 diabetes, suggesting potential immune crosstalk between liver and visceral adipose tissue.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ji-Han Xia, Gong-Hong Wei
MOLECULAR & CELLULAR ONCOLOGY
(2018)