Article
Pharmacology & Pharmacy
Katrin Fasler, Jeanne M. Gunzinger, Daniel Barthelmes, Sandrine A. Zweifel
Summary: This study compared the efficacy of eplerenone therapy versus observation on resolution of subretinal fluid in patients with acute and chronic CSCR. The results showed a decrease in SRF in both groups at 12 months, indicating no significant difference in SRF resolution between treated and observed eyes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Manuel Vilela, Carolina Mengue
Summary: Currently, there is no universally adopted classification system for central serous chorioretinopathy due to unknown aspects related to pathogenesis and clinical spectrum and evolution. The best option may be to aggregate multimodal pieces of information alongside temporal and phenotypic characteristics.
Article
Ophthalmology
A. Valverde-Megias, E. Montolio-Marzo, I. Runkle, J. I. Fernandez-Vigo
Summary: This study aimed to investigate the screening for primary hyperaldosteronism (PA) in acute central serous chorioretinopathy (CSCR) patients. Out of the 19 screened patients, two were found to have PA and were treated with medication. The study suggests a need to screen for PA in hypertensive CSCR patients in real clinical practice.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Dmitri Maltsev, Riccardo Sacconi, Ramesh Venkatesh, Nikitha Gurram Reddy, Shivam Madan, Beatrice Tombolini, Luiz H. Lima, Varsha Pramil, Giridhar Anantharaman, Antonio Marcelo Casella, Gerardo Ledesma-Gil, Nadia Waheed, Enrico Borrelli, Giuseppe Querques, Jay Chhablani
Summary: This study analyzed the longitudinal changes in visual acuity and risk factors for recurrence or development of choroidal neovascularisation (CNV) in eyes with acute or chronic central serous chorioretinopathy (CSCR). The results showed that the recurrence rate of CNV was approximately 30%, and higher age and a higher number of recurrences were associated with a higher risk of early de novo CNV formation.
Article
Medicine, General & Internal
Faisal Iqbal, Kashif Iqbal, Bilal Inayat, Sabeen Arjumand, Zarish Ghafoor, Werdah Sattar, Kiran Abbas
Summary: The study focused on examining the efficacy of short-term eplerenone treatment for chronic central serous chorioretinopathy, finding that it helped reduce choroidal and central macular thickness but did not decrease subretinal fluid height or improve visual acuity. Some mild adverse effects of the treatment were noted, including hypertension and gastrointestinal discomfort.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Ophthalmology
Sumit Randhir Singh, Claudio Iovino, Dinah Zur, Dua Masarwa, Matias Iglicki, Ramkailash Gujar, Marco Lupidi, Dmitrii S. Maltsev, Elodie Bousquet, Mehdi Bencheqroun, Francesca Amoroso, Luiz H. Lima, Srikanta Kumar Padhy, Vishal Govindahari, Khushboo Chandra, Eric H. Souied, Francisco J. Rodriguez, Laura A. Daza, Hernan A. Rios, Carlo Cagini, Enrico Peiretti, Francine Behar-Cohen, Jay Chhablani
Summary: This study aimed to identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR). The results showed that factors such as central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ), and interdigitation zone damage on optical coherence tomography (OCT) were predictive of anatomical and visual outcomes in CSCR eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sampurna Bhattacharyya, Kumar Saurabh, Sudipta Das, Sukanya Gorhe, Zubin D'souza, Rupak Roy
Summary: This study compared the clinical features and outcomes of central serous chorioretinopathy (CSC) with and without pachychoroid. The results showed that CSC eyes with pachychoroid had higher recurrence rates, lower spontaneous resolution rates, and worse final visual acuity compared to CSC eyes without pachychoroid.
Article
Ophthalmology
Niroj Kumar Sahoo, Marco Lupidi, Abhilash Goud, Sankeert Gangakhedkar, Felice Cardillo Piccolino, Jay Chhablani
Summary: The study focused on the structural and functional outcomes of CMD in chronic CSCR, finding that treatment prevents further deterioration of vision, with 63.1% of eyes maintaining or gaining vision. The round configuration of cystoid spaces has a better anatomical outcome.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Adrian T. T. Fung, Yi Yang, Andrew W. W. Kam
Summary: Central serous chorioretinopathy (CSC) is a common non-surgical retinopathy associated with fluid leakage. The exact cause is not fully understood, but changes in the choroid, sclera, and RPE have been observed. CSC can be divided into acute, chronic, and recurrent subtypes, and recent classifications include simple and complex based on RPE changes. Multimodal imaging is useful in the diagnosis and management of CSC and its complications. Treatment options include laser, medications, intravitreal therapy, and surgery, with argon laser and photodynamic therapy having the strongest evidence.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Takeshi Kimura, Takashi Araki, Yuki Komuku, Hisashi Iwami, Fumi Gomi
Summary: The study found that some CSC patients had lower blood serotonin concentrations, which were associated with increased fluorescein leakage points, recurrence of subretinal fluids, and failure to significantly improve BCVA during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Eman Abd-Elhakeem, Mohamed El-Nabarawi, Rehab Shamma
Summary: The study successfully improved the oral bioavailability of Eplerenone through the preparation and optimization of EPL-loaded nanostructured lipid carriers system, which showed good particle size, distribution and entrapment efficiency. Ex-vivo permeation study demonstrated a higher drug permeation rate through rabbit intestine for the optimized drug delivery system compared to the aqueous suspension.
Article
Endocrinology & Metabolism
Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue Xu
Summary: This study suggests that melatonin could be a promising and safe therapeutic strategy for central serous chorioretinopathy (CSC) patients. Melatonin administration inhibited choroidal thickening, vasodilation, and inflammation in an experimental CSC rat model.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Ophthalmology
Alessandro Arrigo, Alessandro Calamuneri, Emanuela Aragona, Alessandro Bordato, Alessio Grazioli Moretti, Alessia Amato, Francesco Bandello, Maurizio Battaglia Parodi
Summary: In this study, the response of CSC to eplerenone or PDT was found to be influenced by choroidal HF and patient age, while RPE and SLT were identified as relevant factors for the onset of MNV.
OPHTHALMOLOGY AND THERAPY
(2021)
Article
Ophthalmology
Doris Fraenkel, Shady Suffo, Achim Langenbucher, Berthold Seitz, Alaa Din Abdin
Summary: Oral eplerenone treatment significantly improved visual acuity, reduced macular thickness, and subretinal fluid height in patients with chronic central serous chorioretinopathy (CSC). The treatment response was particularly significant in patients under stress.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Joost Brinks, Femke M. van Haalen, Thomas J. van Rijssen, Nienke R. Biermasz, Onno C. Meijer, Alberto M. Pereira, Camiel J. F. Boon, Elon H. C. van Dijk
Summary: The study found that ocular abnormalities resembling (subclinical) central serous chorioretinopathy (CSC) are more common than previously thought in patients with active Cushing's syndrome (CS), and may even exist in patients without visual complaints. Early treatment may be necessary to prevent vision loss in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Riccardo Sacconi, Enrico Borrelli, Siva Balasubramanian, Giovanna Vella, Marco Battista, Kiran Kumar Vupparaboina, Jay Chhablani, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to investigate the choroidal vascularity index (CVI) in patients with leptochoroid. The results showed that the choroidal vascular and stromal components in eyes with leptochoroid secondary to reticular pseudodrusen (RPD) and high-myopia exhibited different changes. The impairment of the vascular area in RPD eyes might contribute to the lower development of RPD in patients with high myopia.
Article
Ophthalmology
Sumit Randhir Singh, Deepika C. Parameswarappa, Supriya Arora, Dmitrii S. Maltsev, Niroj Kumar Sahoo, Alexei N. Kulikov, Claudio Iovino, Filippo Tatti, Ramesh Venkatesh, Nikitha Gurram Reddy, Ram Snehith Pulipaka, Enrico Peiretti, Jay Chhablani
Summary: This study reports the disease pattern, progression, and imaging characteristics in eyes with bilateral central serous chorioretinopathy (CSCR). The results show that complex CSCR is more commonly seen in bilateral disease, and eyes with simple CSCR do not convert to the complex type.
Article
Ophthalmology
Ramesh Venkatesh, Rohit Agrawal, Sherina Thomas, Nikitha Gurram Reddy, Aditi Gupta, Naresh Kumar Yadav, Jay Chhablani
Summary: This study reported a case of sequential RPE tears following repeated Ranibizumab injections, in a patient with neovascular AMD and pre-existing RPE tear.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Pranjal Mishra, Harshita Nahata, Nikitha Gurram Reddy, Naresh Kumar Yadav, Jay Chhablani
Summary: The clinical and imaging features as well as treatment outcomes of peripheral polypoidal choroidal vasculopathy (PCV) and macular PCV were compared in this study. The results showed that these two diseases have distinct clinical features and treatment outcomes.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Sameeksha Agrawal, Nikitha Gurram Reddy, Pranjal Mishra, Deepashri Mutalik, Naresh Kumar Yadav, Jay Chhablani
Summary: The study aimed to assess the relationship between retinal pigment clump (RPC) size and location with visual acuity and retinal neovascularisation in eyes with type 2 macular telangiectasia (MacTel). The results showed that female gender, larger pigment size, and its location above the outer plexiform layer were associated with poor vision and proliferative disease.
Article
Ophthalmology
Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Milana Avdalimov, Ramkailash Gujar, Marco Lupidi, Dinah Zur, Jay Chhablani
Summary: The study aims to analyze the 10-year outcomes in simple and complex central serous chorioretinopathy (CSCR) and evaluate the longitudinal changes in multifocal retinal pigment epithelium (RPE) alterations. The results showed that complex CSCR had a worse disease progression, required more treatment, had a higher number of RPE alterations, and had more recurrences compared to simple CSCR.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Alessandro Invernizzi, Jay Chhablani, Francesco Viola, Pierre Henry Gabrielle, Javier Zarranz-Ventura, Giovanni Staurenghi
Summary: Diabetic retinopathy (DR) is a serious complication of diabetes in both adults and the pediatric population. The incidence of DR in children has been increasing due to the rising prevalence of diabetes and obesity. Early screening programs are crucial in diagnosing DR and preventing it from progressing to more severe stages. Management of DR includes glycemic control, medical treatments, and surgical interventions. This review provides a comprehensive overview of the pathophysiology, screening techniques, and available treatments for DR in children.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Ophthalmology
Niroj Kumar Sahoo, Anjali Suresh, Ashika Patil, Joshua Ong, Eman Kazi, Mudit Tyagi, Raja Narayanan, Sameera Nayak, Ninan Jacob, Ramesh Venkatesh, Jay Chhablani
Summary: This study aimed to determine the postoperative en face OCT pattern of closure in idiopathic macular holes (MHs). Two different closure patterns, linear and round, were observed on en face OCT. Patients with linear closure had better visual acuity. Further research is needed to determine the functional significance of these closure patterns.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Aaditi Anilkumar, Rubble Mangla, Shama Sharief, Jay Chhablani
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Editorial Material
Ophthalmology
Sai Prashanti Chitturi, Ramesh Venkatesh, Ashit Handa, Rubble Mangla, Jay Chhablani
Summary: This case report describes a rare presentation of torpedo maculopathy (TM) in a 25-year-old male. The patient had a macular scar in the left eye with a characteristic torpedo-like lesion, which was confirmed as TM based on clinical and imaging findings.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Rubble Mangla, Shama Sharief, Jay Chhablani
Summary: This study aimed to investigate the long-term effects of retinal phototoxicity after macular hole repair surgery with xenon endolight illumination and Brilliant blue G dye. An elderly man underwent vitrectomy with BBG dye for idiopathic full-thickness macular hole repair. The patient experienced progressive damage to the outer retinal layers and retinal pigment epithelium over a 4-year period.
Review
Medicine, General & Internal
Baraa Nawash, Joshua Ong, Matthew Driban, Jonathan Hwang, Jeffrey Chen, Amrish Selvam, Sashwanthi Mohan, Jay Chhablani
Summary: Optical coherence tomography has greatly advanced the diagnosis and management of neovascular age-related macular degeneration. This review aims to assess the prognostic value of OCT-derived biomarkers. The analysis reveals that retinal fluid has the strongest impact on clinical outcomes, including visual acuity and treatment regimens. Consistent findings regarding these OCT prognostic biomarkers can guide personalized clinical decisions and the integration of OCT with artificial intelligence may further improve nAMD therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Costanza Barresi, Jay Chhablani, Rosa Dolz-Marco, Robero Gallego-Pinazo, Alessandro Berni, Francesco Bandello, Enrico Borrelli
Summary: Age-related macular degeneration (AMD) is a complex and multifactorial disease that damages the unit comprising the photoreceptors, retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. While the outer retina is primarily affected, evidence suggests that the inner retina may also be impaired. Structural optical coherence tomography (OCT) technology has shown that both the inner and outer retina are impacted by AMD and that these impairments are associated. This review aims to describe the role of neurodegeneration in AMD to better understand the relationship between neuronal loss and outer retinal damage in this disease.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Engineering, Biomedical
Elham Sadeghi, Sashwanthi Mohan, Danilo Iannetta, Jay Chhablani
Summary: Recent technologies and new devices in vitreoretinal surgeries have improved visualization, safety, and surgical outcomes.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Article
Ophthalmology
Rubble Mangla, Ramesh Venkatesh, Vishma Prabhu, Isha Acharya, Ashit Handa, Atul Thadani, Aishwarya Joshi, Naresh Kumar Yadav, Jay Chhablani
Summary: This study retrospectively analyzed the development and outcome of mid-phase pinpoint hyperfluorescent spots (MPHS) on fundus fluorescein angiography (FFA) in patients with acute central retinal artery occlusion (CRAO). It was found that the presence of MPHS on FFA, along with adjacent minimal late vascular leakage, could indicate a more severe occlusion and poor visual outcomes in patients with CRAO, even after treatment. These MPHS and retinal vessel staining disappeared during follow-up as the CRAO resolved.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
