Article
Chemistry, Medicinal
Manuel Vilela, Carolina Mengue
Summary: Currently, there is no universally adopted classification system for central serous chorioretinopathy due to unknown aspects related to pathogenesis and clinical spectrum and evolution. The best option may be to aggregate multimodal pieces of information alongside temporal and phenotypic characteristics.
Article
Ophthalmology
Nobuhiro Terao, Naoya Imanaga, Sorako Wakugawa, Shota Sawaguchi, Tamaki Tamashiro, Yukihide Yamauchi, Hideki Koizumi
Summary: This study aimed to investigate the prevalence of ciliochoroidal effusion (CE) in central serous chorioretinopathy (CSC) and its association with the clinical features of CSC. The results showed that CE occurred more frequently in CSC patients compared to normal control subjects, and the CE group had thicker sclera than the non-CE group.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Sumit Randhir Singh, Claudio Iovino, Dinah Zur, Dua Masarwa, Matias Iglicki, Ramkailash Gujar, Marco Lupidi, Dmitrii S. Maltsev, Elodie Bousquet, Mehdi Bencheqroun, Francesca Amoroso, Luiz H. Lima, Srikanta Kumar Padhy, Vishal Govindahari, Khushboo Chandra, Eric H. Souied, Francisco J. Rodriguez, Laura A. Daza, Hernan A. Rios, Carlo Cagini, Enrico Peiretti, Francine Behar-Cohen, Jay Chhablani
Summary: This study aimed to identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR). The results showed that factors such as central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ), and interdigitation zone damage on optical coherence tomography (OCT) were predictive of anatomical and visual outcomes in CSCR eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Endocrinology & Metabolism
Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue Xu
Summary: This study suggests that melatonin could be a promising and safe therapeutic strategy for central serous chorioretinopathy (CSC) patients. Melatonin administration inhibited choroidal thickening, vasodilation, and inflammation in an experimental CSC rat model.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Ophthalmology
Adrian T. T. Fung, Yi Yang, Andrew W. W. Kam
Summary: Central serous chorioretinopathy (CSC) is a common non-surgical retinopathy associated with fluid leakage. The exact cause is not fully understood, but changes in the choroid, sclera, and RPE have been observed. CSC can be divided into acute, chronic, and recurrent subtypes, and recent classifications include simple and complex based on RPE changes. Multimodal imaging is useful in the diagnosis and management of CSC and its complications. Treatment options include laser, medications, intravitreal therapy, and surgery, with argon laser and photodynamic therapy having the strongest evidence.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Barbara Stachowska, Jowita Halupczok-Zyla, Justyna Kuliczkowska-Plaksej, Joanna Syrycka, Marek Bolanowski
Summary: Patients with active Cushing's syndrome show altered bone microstructure with decreased TBS, leading to a higher risk of hip and major osteoporotic fractures. TBS appears to be a valuable tool for assessing fracture risk in endogenous hypercortisolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Takeshi Kimura, Takashi Araki, Yuki Komuku, Hisashi Iwami, Fumi Gomi
Summary: The study found that some CSC patients had lower blood serotonin concentrations, which were associated with increased fluorescein leakage points, recurrence of subretinal fluids, and failure to significantly improve BCVA during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Ophthalmology
Supriya Arora, Baldassarre D. Stea, Russell J. Hamilton, Jay Chhablani
Summary: Low dose radiation can be used in refractory cases of central serous chorioretinopathy (CSCR) to decrease the hyperpermeability of large choroidal vessels.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Ophthalmology
Amee D. Azad, Maggie Zhou, Armin R. Afshar, Sophie J. Bakri, Suzann Pershing
Summary: This study analyzed the frequency of systemic corticosteroid prescriptions before and after CSC diagnosis and found that many patients continue to be prescribed steroids after CSC diagnosis. The results suggest a need for greater communication and collaboration among providers to ensure that clinical practice reflects evidence-based recommendations.
Article
Physiology
Fabao Xu, Cheng Wan, Lanqin Zhao, Qijing You, Yifan Xiang, Lijun Zhou, Zhongwen Li, Songjian Gong, Yi Zhu, Chuan Chen, Cong Li, Li Zhang, Chong Guo, Longhui Li, Yajun Gong, Xiayin Zhang, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Daniel Ting, Chenjin Jin, Haotian Lin
Summary: The study aimed to predict the recurrence of central serous chorioretinopathy (CSC) patients using machine learning. The ensemble model performed the best among six different algorithms, demonstrating high accuracy in predicting recurrence at both 3 and 6 months. The simplified model showed comparable predictive power to the ensemble model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Rheumatology
Paul Billoir, Adrien Michon, Luc Darnige
Summary: Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by recurrent thrombotic events and pregnancy morbidity, with persistently presence of antiphospholipid antibodies (aPL). This study reports three cases of central serous chorioretinopathy (CSC) associated with APS.
Article
Multidisciplinary Sciences
Seigo Yoneyama, Ayumi Fukui, Yoichi Sakurada, Nobuhiro Terao, Taiyo Shijo, Natsuki Kusada, Atsushi Sugiyama, Mio Matsubara, Yoshiko Fukuda, Wataru Kikushima, Ravi Parikh, Fumihiko Mabuchi, Chie Sotozono, Kenji Kashiwagi
Summary: This study investigated the differences in clinical and genetic characteristics between males and females with central serous chorioretinopathy (CSC), finding significant age differences, subfoveal choroidal thickness variations, and central retinal thickness disparities, as well as differences in the frequency of a descending tract between genders.
SCIENTIFIC REPORTS
(2022)
Review
Ophthalmology
Sumit Randhir Singh, John Thomas Gote, Jay Chhablani
Summary: Central serous chorioretinopathy (CSCR) is a common chorioretinal disease with various manifestations. Acute CSCR presents with localized neurosensory detachment, while chronic CSCR may show widespread changes in the retinal pigment epithelium (RPE), chronic shallow subretinal fluid, and choroidal neovascularization (CNV). Despite multiple treatment options, there is a lack of standardized treatment protocol or gold standard treatment modality.
Review
Ophthalmology
Richard F. Spaide, Chui Ming Gemmy Cheung, Hidetaka Matsumoto, Shoji Kishi, Camiel J. F. Boon, Elon H. C. van Dijk, Martine Mauget-Faysse, Francine Behar-Cohen, M. Elizabeth Hartnett, Sobha Sivaprasad, Tomohiro Iida, David M. Brown, Jay Chhablani, Peter M. Maloca
Summary: Central serous chorioretinopathy (CSC) is characterized by fluid leakage at the level of the retinal pigment epithelium, leading to macular detachment. Recent evaluations have shown that eyes with CSC have similar choroidal vascular abnormalities as eyes following occlusion of the vortex veins or carotid cavernous sinus fistulas. Abnormal venous outflow from the choroid appears to be a key factor in the pathophysiology of CSC.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Ophthalmology
Orhan Altunel, Hasan Basri Arifoglu
Summary: The study compared retinal vessel diameters between healthy eyes and eyes with active CSC, finding significantly thicker venous walls and narrower inner diameters in active CSC eyes. Additionally, the mean venous outer diameter was wider in CSC eyes, albeit not significantly.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Mariantonia Ferrara, Vito Romano, Claudio Iovino, Mustafa R. Kadhim, Elon H. C. van Dijk, Camiel J. F. Boon, Piergiacomo Grassi, Sibel Demirel, Cristian Cartes, Mario R. Romano
Summary: This study aimed to identify the preferences of audience and faculty in digital education sessions in ophthalmology. The survey results showed that most respondents preferred digital education sessions to last 30-60 minutes without a break, to be held in the evening time-slot of a weekday. The availability of webinars and recorded surgical videos/clinical cases, associated with live discussion, were considered the most important opportunities in digital educational channels.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tin Yan Alvin Liu, Carlthan Ling, Leo Hahn, Craig K. Jones, Camiel J. F. Boon, Mandeep S. Singh
Summary: This study demonstrates the use of cSLO imaging and deep learning to estimate visual acuity in retinitis pigmentosa (RP) patients, showing promising performance in predicting visual impairment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Elon H. C. van Dijk, Helena M. A. Feenstra, Jakob Bjerager, Jakob Grauslund, Camiel J. F. Boon, Yousif Subhi
Summary: The treatment of chronic central serous chorioretinopathy (cCSC) is controversial. This study reviewed the short-term efficacy of different cCSC treatments and found that half-dose/half-fluence photodynamic therapy (PDT), conventional laser, and selective retina therapy (SRT) provide significant improvement compared to no treatment. Half-dose/half-fluence PDT is the only viable treatment option for cCSC patients.
ACTA OPHTHALMOLOGICA
(2023)
Review
Endocrinology & Metabolism
Freddy Jeanneteau, Onno C. Meijer, Marie-Pierre Moisan
Summary: There is a dissociation between the positive and negative effects of cortisol, a stress hormone, which poses a challenge in developing anti-inflammatory glucocorticoids for brain disorders. Recent advances in structural molecular dynamics allow for the engineering of glucocorticoids that can selectively target downstream signaling pathways, reducing the harmful effects of cortisol on the brain and behavior.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Amir H. Zamanipoor Najafabadi, Merel van der Meulen, Ana Luisa Priego Zurita, S. Faisal Ahmed, Wouter R. van Furth, Evangelia Charmandari, Olaf Hiort, Alberto M. Pereira, Mehul Dattani, Diana Vitali, Johan P. de Graaf, Nienke R. Biermasz
Summary: The European Reference Network on Rare Endocrine Conditions (Endo-ERN) aims to improve healthcare for pituitary adenoma patients in Europe. This study reviewed surgical outcomes of pituitary adenoma patients within Endo-ERN MTG6 reference centers between 2010 and 2019. The study found that the remission rates varied for different types of adenomas, and a majority of centers used endoscopic surgery with the collaboration of ENT surgeons.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Eva M. G. Viho, Jan Kroon, Richard A. Feelders, Rene Houtman, Elisabeth S. R. van den Dungen, Alberto M. Pereira, Hazel J. Hunt, Leo J. Hofland, Onno C. Meijer
Summary: Glucocorticoid stress hormones are essential for physiology and exert numerous actions via binding to the glucocorticoid receptor (GR). Relacorilant is a selective GR antagonist being evaluated for the treatment of endogenous Cushing's syndrome. This study compared the effects of relacorilant and the non-selective antagonist mifepristone, showing that relacorilant has potent antagonistic effects on GR signaling and prevents anti-inflammatory effects of glucocorticoids.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Onno C. Meijer, Jacobus C. Buurstede, Eva M. G. Viho, Jorge Miguel Amaya, Anne-Sophie C. A. M. Koning, Merel Van Der Meulen, Lisa T. C. M. Van Weert, Susana N. Paul, Jan Kroon, Lisa L. Koorneef
Summary: Glucocorticoids modulate brain function through the regulation of gene transcription. However, linking gene expression to function is challenging due to the extensive and pleiotropic genomic responses. The transcriptional activity of MR and GR is influenced by cellular context and other active signaling pathways.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Tessa N. A. Slagboom, Dirk Jan Stenvers, Elsmarieke van de Giessen, Stefan D. D. Roosendaal, Maartje M. L. de Win, Joseph C. J. Bot, Eleonora Aronica, Rene Post, Jantien Hoogmoed, Madeleine L. L. Drent, Alberto M. M. Pereira
Summary: The study provides a structured analysis of the diagnostic accuracy and clinical use of molecular imaging in patients with ACTH-dependent Cushing's syndrome, as well as the role of multidisciplinary counseling in decision making. It proposes a complementary diagnostic algorithm for both de novo and recurrent or persistent Cushing's disease. The use of molecular imaging modalities is of added and complementary value in the detection of pituitary microadenoma in ACTH-dependent Cushing's syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Fabian Wolters, Henriet van Middendorp, Omer Van den Bergh, Nienke R. Biermasz, Onno C. Meijer, Andrea W. M. Evers
Summary: This study aims to investigate the effects of scent conditioning during sleep on cortisol and the diurnal rhythm by utilizing the cortisol awakening response (CAR) as an unconditioned response. The results of this study can provide new insights into the effects of learning on cortisol and the diurnal rhythm, with potential clinical implications in the treatment of sleep and stress disorders.
JMIR RESEARCH PROTOCOLS
(2023)
Review
Endocrinology & Metabolism
Stephan Petersenn, Maria Fleseriu, Felipe F. Casanueva, Andrea Giustina, Nienke Biermasz, Beverly M. K. Biller, Marcello Bronstein, Philippe Chanson, Hidenori Fukuoka, Monica Gadelha, Yona Greenman, Mark Gurnell, Ken K. Y. Ho, Juergen Honegger, Adriana G. Ioachimescu, Ursula B. Kaiser, Niki Karavitaki, Laurence Katznelson, Maya Lodish, Dominique Maiter, Hani J. Marcus, Ann Mccormack, Mark Molitch, Christopher A. Muir, Sebastian Neggers, Alberto M. Pereira, Rosario Pivonello, Kalmon Post, Gerald Raverot, Roberto Salvatori, Susan L. Samson, Ilan Shimon, Joanna Spencer-Segal, Greisa Vila, John Wass, Shlomo Melmed
Summary: This Consensus Statement provides evidence-based graded consensus recommendations and key summary points for clinical practice on the diagnosis and management of prolactinomas. It covers various aspects including epidemiology, pathogenesis, clinical presentation, assessment, imaging strategies, complications, and treatment in special situations. The workshop emphasizes the need for additional therapeutic options to address clinical challenges in treating these patients.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Correction
Multidisciplinary Sciences
S. M. Bruijn, O. G. Meijer, P. J. Beek, J. H. van Dieen
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Biochemistry & Molecular Biology
Eva M. G. Viho, A. Mattijs Punt, Ben Distel, Rene Houtman, Jan Kroon, Ype Elgersma, Onno C. Meijer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Anne-Sophie C. A. M. Koning, Merel van der Meulen, Daphne Schaap, Djaina D. Satoer, Christiaan H. Vinkers, Elisabeth F. C. van Rossum, Wouter R. van Furth, Alberto M. Pereira, Onno C. Meijer, Olaf M. Dekkers
Summary: The proportion of neuropsychiatric adverse effects in patients using synthetic glucocorticoids is high, with depression and mania being the most significant associations. Awareness of possible psychiatric side effects is essential when starting glucocorticoid treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)