Review
Chemistry, Analytical
Tais Aparecida Reis Cordeiro, Mayra Asevedo Campos de Resende, Simone Cristina dos Santos Moraes, Diego Leoni Franco, Arnaldo Cesar Pereira, Lucas Franco Ferreira
Summary: Neglected tropical diseases are a group of infectious and parasitic diseases prevalent in tropical and subtropical regions, with limited access to proper healthcare. The development of low-cost biosensors for fast diagnosis in these areas is crucial for better treatment and eradication. While progress has been made in the past decade, challenges remain in early detection of neglected tropical diseases using biosensors.
Review
Rheumatology
Rasmi Ranjan Sahoo, Anupam Wakhlu, Vikas Agarwal
Summary: Dealing with rheumatic diseases in tropical countries is complex due to limited healthcare infrastructure, lack of diagnostic and therapeutic facilities, impact of dominant prevalent diseases, and challenges in differentiating from infectious and non-infectious disease mimics. Several tropical diseases present with musculoskeletal and rheumatic manifestations, leading to delayed diagnosis or misdiagnosis and poor patient outcomes.
CLINICAL RHEUMATOLOGY
(2022)
Article
Business
David B. Audretsch, Maksim Belitski, Rosa Caiazza, Donald Siegel
Summary: This paper fills the research gap by investigating the impact of open innovation on startups and how it enhances innovative activity. The study finds that specific external partners and their geographical location significantly affect product and process innovation in startups. The positive impact of open innovation reflects the heterogeneous effects of knowledge embedded in different partner types and the role of technological, institutional, and competitive arrangements in startup innovation.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Article
Computer Science, Software Engineering
Simon Butler, Jonas Gamalielsson, Bjorn Lundell, Christoffer Brax, Johan Sjoberg, Anders Mattsson, Tomas Gustavsson, Jonas Feist, Erik Lonroth
Summary: This research investigates the various work practices used by company contributors to engage with and contribute to eight community OSS projects, finding that companies choose contribution methods based on their needs and capabilities. Factors influencing contributor work practices can be complex, arising from considerations such as company and project structure, technical concerns, and commercial strategies.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2021)
Review
Pharmacology & Pharmacy
Rachel H. Clare, Steven R. Hall, Rohit N. Patel, Nicholas R. Casewell
Summary: Snakebite envenoming causes up to 138,000 deaths annually, making it the deadliest neglected tropical disease. Current treatment with biologic antivenoms is outdated and expensive, but there is great potential in developing small molecule drugs to inhibit venom toxins. Strategies successful in treating other NTDs could be utilized to facilitate the development of next-generation snakebite treatments.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
Martin Walker, Jonathan I. D. Hamley, Philip Milton, Frederic Monnot, Sally Kinrade, Sabine Specht, Belen Pedrique, Maria-Gloria Basanez
Summary: Drug-based interventions are crucial in addressing major diseases, with a growing consensus on the need for new therapeutic options in some cases. In this field, minimizing wastage of money and resources is essential.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Hollie-Ann Hatherell, Hope Simpson, Rebecca F. Baggaley, T. Deirdre Hollingsworth, Rachel L. Pullan
Summary: The WHO's 2030 road map for neglected tropical diseases highlights the importance of strengthened, institutionalized post-elimination surveillance, but lacks practical guidance on implementation. Nationally representative survey programs, such as DHS, may provide a platform for integrating disease surveillance within national health systems, with a focus on maximizing utility and addressing priorities for further data collection and characterization.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Wendemagegn Enbiale, Alemayehu Bekele, Nigus Manaye, Fikre Seife, Zeyede Kebede, Filmon Gebremeskel, Johan van Griensven
Summary: Subcutaneous mycoses are endemic in Ethiopia, with cases reported throughout the country, especially in the northern regions. The lack of research and surveillance programs for these diseases highlights the need for routine programs and systems to identify and record cases.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Pharmacology & Pharmacy
Leonardo L. G. Ferreira, Josue de Moraes, Adriano D. Andricopulo
Summary: Neglected tropical diseases, such as leishmaniasis and schistosomiasis, continue to be a public health challenge in developing countries. However, advancements in drug discovery using modern strategies have shown promise in addressing these diseases by combining medicinal chemistry and parasite biology.
DRUG DISCOVERY TODAY
(2022)
Article
Immunology
Amanda Minter, Lorenzo Pellis, Graham F. Medley, T. Deirdre Hollingsworth
Summary: As countries strive to meet WHO goals for reducing morbidity and eliminating disease transmission, they will need to plan for the next stages of surveillance and control in low prevalence settings. Going beyond simple predictions of treatment program effectiveness, more nuanced intervention choices informed by quantitative analyses will be necessary for sustainable gains in the long term. Identifying policy goals and finding the right balance between intervention and surveillance constraints will be key challenges in achieving multiple aims such as minimizing morbidity and costs simultaneously.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Theresa W. Gyorkos, Helene Carabin, Maneesh Phillip, Leshawn Benedict, Amy Davis, Janet Hatcher Roberts, Kishor M. Wasan, Momar Ndao, Alison Krentel
Summary: Canadian researchers have published over 160 publications per year on neglected tropical diseases between 2010 and 2019, covering all 20 NTDs. The most commonly studied diseases were leishmaniasis, dengue fever, chikungunya, Chagas disease, soil-transmitted helminthiases, and rabies.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Review
Chemistry, Medicinal
Igor Jose dos Santos Nascimento, Misael de Azevedo Teotonio Cavalcanti, Ricardo Olimpio de Moura
Summary: Neglected tropical diseases (NTDs) are a group of infectious diseases that mainly affect impoverished populations in tropical countries. They cause many deaths worldwide and require substantial investments in public health to treat and control them. Protozoan diseases such as Chagas disease, sleeping sickness, and Leishmaniasis, as well as the big three diseases (AIDS, tuberculosis, and malaria), are endemic in tropical countries. However, there is still a gap in treatment, emphasizing the need for new alternatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, General & Internal
Juan Garcia-Bernalt Diego, Pedro Fernandez-Soto, Antonio Muro
Summary: Neglected Tropical Diseases (NTDs), particularly those caused by parasites, continue to be a major public health issue in tropical and subtropical regions, affecting 10% of the global population. Isothermal nucleic acid amplification techniques, especially loop-mediated isothermal amplification (LAMP), have emerged as an affordable alternative to PCR for molecular diagnostics in parasite-caused NTDs.
Review
Biochemistry & Molecular Biology
Kush K. Maheshwari, Debasish Bandyopadhyay
Summary: NTDs affect a vast population, mainly in developing countries, with WHO identifying 20 priority diseases. Heterocyclic drugs show promising therapeutic activity against NTDs. The study aims to raise awareness, discuss treatment options, and highlight the need for further research on NTDs.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Psychology, Multidisciplinary
Maoxiang Wang, Ruili Zhang, Rasheed Abdulwase, Shuangsheng Yan, Mohsin Muhammad
Summary: In the era of knowledge economy, traditional closed innovation can no longer meet market demands. Enterprises need to embrace open innovation and utilize both internal and external resources to apply innovation achievements in commercial settings. By establishing an open innovation ecosystem and a collaborative platform, enterprises can seek technical and resource support, enhance their independent innovation capability, achieve value co-creation, and establish mutually beneficial cooperation with partners.
FRONTIERS IN PSYCHOLOGY
(2022)