Innovation in neglected tropical disease drug discovery and development

Phenotypic screening approaches for Chagas disease drug discovery

(2017) Eric Chatelain et al.   Expert Opinion on Drug Discovery

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Progress Report on Neglected Tropical Disease Drug Donation Programs

(2016) Joshua P. Cohen et al.   CLINICAL THERAPEUTICS

The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

(2016) Peter Cheuka et al.   MOLECULES

Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

(2016) Britta Stadelmann et al.   PLoS Neglected Tropical Diseases

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

(2016) Stephen Patterson et al.   eLife

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

Automated High-Content Assay for Compounds Selectively Toxic to Trypanosoma cruzi in a Myoblastic Cell Line

(2015) Julio Alonso-Padilla et al.   PLoS Neglected Tropical Diseases

Applied Research for Better Disease Prevention and Control

(2015) Johannes Sommerfeld et al.   PLoS Neglected Tropical Diseases

High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis

(2015) Ting Li et al.   Infectious Diseases of Poverty

Measuring Progress in Neglected Disease Drug Development

(2014) Joshua P. Cohen et al.   CLINICAL THERAPEUTICS

An Image-Based Algorithm for Precise and Accurate High Throughput Assessment of Drug Activity against the Human Parasite Trypanosoma cruzi

(2014) Seunghyun Moon et al.   PLoS One

Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

(2014) Gregory J. Crowther et al.   PLoS Neglected Tropical Diseases

Global aspirations, local realities: the role of social science research in controlling neglected tropical diseases

(2014) Kevin Bardosh   Infectious Diseases of Poverty

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

(2013) Manu De Rycker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mapping of available health research and development data: what's there, what's missing, and what role is there for a global observatory?

(2013) John-Arne Røttingen et al.   LANCET

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

(2013) ROB DON et al.   PARASITOLOGY

Developing global health technology standards: what can other industries teach us?

(2013) Hassan Masum et al.   Globalization and Health

High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery

(2013) Nathalie Aulner et al.   PLoS Neglected Tropical Diseases

The Global Health Innovative Technology (GHIT) Fund: financing medical innovations for neglected populations

(2013) BT Slingsby et al.   Lancet Global Health

First Universities Allied for Essential Medicines (UAEM) Neglected Diseases and Innovation Symposium

(2012) Laura W. Musselwhite et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Parasite makes mice fearless by hijacking immune cells

(2012) Debora Mackenzie   NEW SCIENTIST

High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity

(2012) Anuradha Kumar et al.   PLoS One

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

(2012) S. Wyllie et al.   Science Translational Medicine

Innovation and Access to Medicines for Neglected Populations: Could a Treaty Address a Broken Pharmaceutical R&D System?

(2012) Suerie Moon et al.   PLOS MEDICINE

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

(2012) Ross A. Paveley et al.   PLoS Neglected Tropical Diseases

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

(2012) Chris Marcellino et al.   PLoS Neglected Tropical Diseases

Design, Synthesis, and Structure−Activity Relationship ofTrypanosoma bruceiLeucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents

(2011) Dazhong Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Innovative Partnerships for Drug Discovery against Neglected Diseases

(2011) Palle H. Jakobsen et al.   PLoS Neglected Tropical Diseases

Activity In Vivo of Anti-Trypanosoma cruzi Compounds Selected from a High Throughput Screening

(2011) Grasiella Andriani et al.   PLoS Neglected Tropical Diseases

Socioeconomic aspects of neglected tropical diseases

(2010) Lesong Conteh et al.   LANCET

High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi

(2010) L.L. Nohara et al.   PARASITOLOGY INTERNATIONAL

“Manifesto” for Advancing the Control and Elimination of Neglected Tropical Diseases

(2010) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Neglected Disease Research and Development: How Much Are We Really Spending?

(2009) Mary Moran et al.   PLOS MEDICINE

The Future of TDR: The Need to Adapt to a Changing Global Health Environment

(2008) Daniel J. Carucci et al.   PLoS Neglected Tropical Diseases

Two Years after the Fourth External Review: TDR Moves Forward with a New Vision and Strategy

(2008) Robert G. Ridley et al.   PLoS Neglected Tropical Diseases

A Global Fund to Fight Neglected Tropical Diseases: Is the G8 Hokkaido Toyako 2008 Summit Ready?

(2008) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

TDR Thirty Years On: Taking Stock and Envisioning the Future for the Special Programme for Research and Training in Tropical Diseases

(2008) Abdallah S. Daar et al.   PLoS Neglected Tropical Diseases