Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function

(2018) Darren Q. Tan et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Mitochondrial DNA 4977 bp deletion is a common phenomenon in hair and increases with age

(2017) Yijie Zheng et al.   Bosnian Journal of Basic Medical Sciences

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice

(2017) Shinichi Someya et al.   PLoS One

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

(2016) Milena Pinto et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Mitochondria and mtDNA integrity in stem cell function and differentiation

(2016) Riikka H Hämäläinen   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

(2016) Johanna H.K. Kauppila et al.   Cell Reports

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival

(2015) Amabel M. Orogo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction

(2015) K.J. Ahlqvist et al.   Nature Communications

Mitochondrial DNA Mutations and Cancer

(2014) Konstantin Popadin et al.   AMERICAN JOURNAL OF PATHOLOGY

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

(2014) XiuJie Li-Harms et al.   BLOOD

Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases

(2014) Tian Wang et al.   CELL

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

(2014) Holly L. Baines et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

(2013) Holly L. Baines et al.   AGING CELL

Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool

(2013) Xiao Wang et al.   HUMAN MOLECULAR GENETICS

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

(2012) Raymond G. Fox et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Towards germline gene therapy of inherited mitochondrial diseases

(2012) Masahito Tachibana et al.   NATURE

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

(2012) Laura C. Greaves et al.   PLoS Genetics

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

Manifestations and mechanisms of stem cell aging

(2011) Ling Liu et al.   JOURNAL OF CELL BIOLOGY

Emerging models and paradigms for stem cell ageing

(2011) D. Leanne Jones et al.   NATURE CELL BIOLOGY

Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration

(2010) Amy K. Reeve et al.   Annals of the New York Academy of Sciences

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

(2010) Laura C. Greaves et al.   EXPERIMENTAL GERONTOLOGY

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons

(2009) Amy K. Reeve et al.   AGING CELL

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

(2009) Marco Nooteboom et al.   AGING CELL

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

(2009) M. L. Chen et al.   BLOOD

Selection against Pathogenic mtDNA Mutations in a Stem Cell Population Leads to the Loss of the 3243A→G Mutation in Blood

(2008) Harsha Karur Rajasimha et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The 4977bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more?

(2008) Christoph Meissner et al.   EXPERIMENTAL GERONTOLOGY

Locating the stem cell niche and tracing hepatocyte lineages in human liver

(2008) Tariq G. Fellous et al.   HEPATOLOGY

Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations

(2008) Lydia Gutierrez-Gonzalez et al.   JOURNAL OF PATHOLOGY

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease

(2008) James Bruce Stewart et al.   NATURE REVIEWS GENETICS

Mitochondrial DNA mutations and aging: devils in the details?

(2008) Konstantin Khrapko et al.   TRENDS IN GENETICS

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY

Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells

(2007) Stuart A.C. McDonald et al.   GASTROENTEROLOGY