Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time

(2018) Birgit Goversen et al.   Frontiers in Physiology

Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp

(2017) Arie Verkerk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI)

(2017) Yogi A. Patel et al.   PLoS Computational Biology

Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets

(2017) Hrayr S. Karagueuzian et al.   Frontiers in Pharmacology

Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells

(2017) Maike Marczenke et al.   Frontiers in Physiology

Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density

(2017) Marc D. Lemoine et al.   Scientific Reports

IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes

(2016) Ravi Vaidyanathan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp

(2016) Tashalee R. Brown et al.   BIOPHYSICAL JOURNAL

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility

(2016) Ryan A. Devenyi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cell-specific Dynamic Clamp analysis of the role of funny I f current in cardiac pacemaking

(2016) E. Ravagli et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

(2016) Christiaan C. Veerman et al.   Scientific Reports

IKrImpact on Repolarization and Its Variability Assessed by Dynamic Clamp

(2015) Claudia Altomare et al.   Circulation-Arrhythmia and Electrophysiology

Repolarization Reserve Evolves Dynamically During the Cardiac Action Potential

(2015) Thao P. Nguyen et al.   Circulation-Arrhythmia and Electrophysiology

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

(2015) H. D. Devalla et al.   EMBO Molecular Medicine

Targeting the late component of the cardiac L-type Ca2+current to suppress early afterdepolarizations

(2015) Roshni V. Madhvani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Combined action potential- and dynamic-clamp for accurate computational modelling of the cardiac IKr current

(2015) Chiara Bartolucci et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1

(2015) Rosalie M. E. Meijer van Putten et al.   Frontiers in Physiology

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Electronic “expression” of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells

(2013) Glenna C.L. Bett et al.   HEART RHYTHM

Size and Ionic Currents of Unexcitable Cells Coupled to Cardiomyocytes Distinctly Modulate Cardiac Action Potential Shape and Pacemaking Activity in Micropatterned Cell Pairs

(2012) Luke C. McSpadden et al.   Circulation-Arrhythmia and Electrophysiology

Transient outward K+current reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes

(2012) A. J. Workman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr

(2012) Michael Xavier Doss et al.   PLoS One

Rapid Genetic Algorithm Optimization of a Mouse Computational Model: Benefits for Anthropomorphization of Neonatal Mouse Cardiomyocytes

(2012) Corina T. Bot et al.   Frontiers in Physiology

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias

(2012) Maaike Hoekstra et al.   Frontiers in Physiology

Arrhythmogenic consequences of myofibroblast–myocyte coupling

(2011) Thao P. Nguyen et al.   CARDIOVASCULAR RESEARCH

Shaping a new Ca2+conductance to suppress early afterdepolarizations in cardiac myocytes

(2011) Roshni V. Madhvani et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of the Transient Outward Current in Regulating Mechanical Properties of Canine Ventricular Myocytes

(2010) MIN DONG et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Anthropomorphizing the Mouse Cardiac Action Potential via a Novel Dynamic Clamp Method

(2009) Rebecca C. Ahrens-Nicklas et al.   BIOPHYSICAL JOURNAL

Multiple effects of 4-aminopyridine on feline and rabbit sinoatrial node myocytes and multicellular preparations

(2009) Iván A. Aréchiga-Figueroa et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling

(2008) Lai-Hua Xie et al.   CIRCULATION RESEARCH

Effects of imperfect dynamic clamp: Computational and experimental results

(2007) Jonathan C. Bettencourt et al.   JOURNAL OF NEUROSCIENCE METHODS