Article
Immunology
Martina Sundqvist, Karin Christenson, Per Wekell, Halla Bjornsdottir, Agnes Dahlstrand Rudin, Felix P. Sanchez Klose, Tilmann Kallinich, Amanda Welin, Lena Bjorkman, Johan Bylund, Anna Karlsson-Bengtsson, Stefan Berg
Summary: This article describes a female patient with severe chronic non-bacterial osteomyelitis (CNO) and complete deficiency of myeloperoxidase (MPO). The patient showed a good response to TNF-alpha blockade (adalimumab), suggesting a possible link between the MPO deficiency and abnormal neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anthony L. Sylvester, David X. Zhang, Sophia Ran, Natalya S. Zinkevich
Summary: Reactive oxygen species (ROS) play important roles in health and disease, with both beneficial and harmful effects. Different sources of ROS have different roles in various pathologies. NOX1 is associated with hypertension through ROS production, making it a promising therapeutic target. NOX2 and NOX4 produce hydrogen peroxide, influencing cellular processes. Increased ROS production from NOX5 contributes to atherosclerosis.
Article
Pharmacology & Pharmacy
Meng-Yan Deng, Khalil Ali Ahmad, Qiao-Qiao Han, Zi-Ying Wang, Rana Muhammad Shoaib, Xin-Yan Li, Yong-Xiang Wang
Summary: The study showed that thalidomide alleviates neuropathic pain by upregulating spinal microglial IL-10 and beta-endorphin expression rather than downregulating TNF alpha expression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Nadeem Akhter, Ajit Wilson, Reeby Thomas, Fatema Al-Rashed, Shihab Kochumon, Areej Al-Roub, Hossein Arefanian, Ashraf Al-Madhoun, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Summary: IL-8/MCP-1 expression in adipose tissue is elevated in obesity. The synergistic effect of ROS/TNF-alpha can drive the expression of chemokines in monocytic cells, potentially through inducing ER stress, HIF1A stabilization, and signaling via NF-kappa B/ERK-1,2. NAC may have a therapeutic significance in inhibiting oxidative stress-driven IL-8/MCP-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zhouyangfan Peng, Mingwu Duan, Yiting Tang, Jianfeng Wu, Kai Zhao, Yanjun Zhong, Zhihui He, Jie Meng, Fangping Chen, Xianzhong Xiao, Haichao Wang, Timothy R. Billiar, Ben Lu, Fang Liang
Summary: Silicosis is caused by inhalation of crystalline silica dust particles, and impaired interferon gamma signaling in myeloid cells is strongly associated with the occurrence of the disease. Interferon gamma priming of macrophages can partially inhibit the inflammatory response induced by crystalline silica.
Article
Cell Biology
Shasha Yin, Liu Liu, Lauren E. Ball, Yalong Wang, Mark T. Bedford, Stephen A. Duncan, Haizhen Wang, Wenjian Gan
Summary: This study identifies protein arginine methyltransferase 1 (PRMT1) as a critical regulator of the GATOR2 complex, which activates the mTORC1 pathway for tumor growth. Inhibition of the CDK5-PRMT1-WDR24 axis suppresses HCC cell proliferation and tumor growth. High PRMT1 protein expression is associated with elevated mTORC1 signaling in patients with HCC.
Review
Biochemistry & Molecular Biology
Deyamira Matuz-Mares, Hector Vazquez-Meza, Maria Magdalena Vilchis-Landeros
Summary: The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or NOX) plays a critical role in inflammatory response and fibrosis in multiple organs, especially in the liver. It contributes to hepatic fibrosis by generating reactive oxygen species (ROS) and affecting various cellular processes. ROS production by NADPH oxidase family members, including NOX1, NOX2, and NOX4, is also associated with oxidative stress in liver diseases.
Article
Microbiology
Xiaohan Zhu, Mohammad Sayari, Md. Rashidul Islam, Fouad Daayf
Summary: NADPH oxidase (Nox) genes are responsible for the production of Reactive Oxygen Species (ROS) in living organisms, playing important roles in the virulence of pathogens such as Verticillium dahliae. The expression of NoxA gene is closely related to the aggressiveness of V. dahliae in plants, indicating its essential role in pathogenesis.
Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Alice Santos-Silva, Luis Belo
Summary: Chronic kidney disease is a global public health problem with high morbidity and mortality. Inflammation and inflammatory mediators, such as tumor necrosis factor-related biomarkers, play a role in the development and progression of CKD. Tumor necrosis factor receptors 1 and 2 have been associated with changes in kidney function and injury, and could potentially serve as biomarkers for CKD prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kaiwen Liu, Jianlu Wei, Guohua Li, Ronghan Liu, Dawang Zhao, Yuanqiang Zhang, Jie Shi, Qing Xie, Lei Cheng
Summary: The study found that Fexofenadine protects against TNF-alpha-induced inflammatory disc degeneration and promotes disc integrity through inhibiting ECM degradation and rescuing inflammation. Additionally, Fexofenadine may serve as a potential target for treating other inflammatory-related diseases, including IVD degeneration, by modulating various pathways and signaling mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Birandra K. Sinha, Erik J. Tokar, Jianying Li, Pierre R. Bushel
Summary: The nitric oxide donor NCX4040 exhibits cytotoxicity towards ovarian tumor cells by generating reactive oxygen species and inducing DNA damage. It also depletes cellular glutathione and induces oxidative stress, resulting in tumor cell death. NCX4040 treatment leads to the induction of oxidative stress genes, inflammatory response genes, DNA damage response genes, and MAP kinase response genes.
Article
Immunology
Chuen-Mao Yang, Chien-Chung Yang, Li-Der Hsiao, Chia-Ying Yu, Hui-Ching Tseng, Chih-Kai Hsu, Jiro Hasegawa Situmorang
Summary: The study found that TNF-α induces upregulation of COX-2 and PGE(2) through a TNFR1-dependent MitoROS/PKCα/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs. This sheds new light on the mechanisms of TNF-α in cardiac fibrosis and heart failure.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Saswati Banerjee, Wei Xu, Aaron Doctor, Adel Driss, Ceana Nezhat, Neil Sidell, Robert N. Taylor, Winston E. Thompson, Indrajit Chowdhury
Summary: Endometriosis is a gynecological disorder characterized by immune system dysregulation. The cytokine TNFa plays a role in the pathogenesis of endometriosis through dysregulation of microRNAs and activation of inflammatory signaling pathways. Curcumin can inhibit TNFa expression and restore miRNA levels.
Article
Multidisciplinary Sciences
Malin Collin, Malin Ernberg, Nikolaos Christidis, Britt Hedenberg-Magnusson
Summary: This study investigated the detectability and concentration of cytokines and chemokines in the saliva of children with juvenile idiopathic arthritis (JIA), as well as the saliva flow and the influence of orofacial pain on saliva flow. The results showed that there was no significant difference in the levels of cytokines and chemokines in the saliva between children with JIA and healthy controls. However, there was an association between orofacial pain and reduced saliva flow rate for both groups.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Mario Alfredo Parra, Sandra Baez, Lucas Sedeno, Cecilia Gonzalez Campo, Hernando Santamaria-Garcia, Ivan Aprahamian, Paulo H. F. Bertolucci, Julian Bustin, Maria Aparecida Camargos Bicalho, Carlos Cano-Gutierrez, Paulo Caramelli, Marcia L. F. Chaves, Patricia Cogram, Barbara Costa Beber, Felipe A. Court, Leonardo Cruz de Souza, Nilton Custodio, Andres Damian, Myriam de la Cruz, Roberta Diehl Rodriguez, Sonia Maria Dozzi Brucki, Lais Fajersztajn, Gonzalo A. Farias, Fernanda G. De Felice, Raffaele Ferrari, Fabricio Ferreira de Oliveira, Sergio T. Ferreira, Ceres Ferretti, Marcio Luiz Figueredo Balthazar, Norberto Anizio Ferreira Frota, Patricio Fuentes, Adolfo M. Garcia, Patricia J. Garcia, Fabio Henrique de Gobbi Porto, Lissette Duque Penailillo, Henry Willy Engler, Irene Maier, Ignacio F. Mata, Christian Gonzalez-Billault, Oscar L. Lopez, Laura Morelli, Ricardo Nitrini, Yakeel T. Quiroz, Alejandra Guerrero Barragan, David Huepe, Fabricio Joao Pio, Claudia Kimie Suemoto, Renata Kochhann, Silvia Kochen, Fiona Kumfor, Serggio Lanata, Bruce Miller, Leticia Lessa Mansur, Mirna Lie Hosogi, Patricia Lillo, Jorge Llibre Guerra, David Lira, Francisco Lopera, Adelina Comas, Jose Alberto Avila-Funes, Ana Luisa Sosa, Claudia Ramos, Elisa de Paula Franca Resende, Heather M. Snyder, Ioannis Tarnanas, Jenifer Yokoyama, Juan Llibre, Juan Felipe Cardona, Kate Possin, Kenneth S. Kosik, Rosa Montesinos, Sebastian Moguilner, Patricia Cristina Lourdes Solis, Renata Eloah de Lucena Ferretti-Rebustini, Jeronimo Martin Ramirez, Diana Matallana, Lingani Mbakile-Mahlanza, Alyne Mendonca Marques Ton, Ronnielly Melo Tavares, Eliane C. Miotto, Graciela Muniz-Terrera, Luis Arnoldo Munoz-Nevarez, David Orozco, Maira Okada de Oliveira, Olivier Piguet, Maritza Pintado Caipa, Stefanie Danielle Pina Escudero, Lucas Porcello Schilling, Andre Luiz Rodrigues Palmeira, Monica Sanches Yassuda, Jose Manuel Santacruz-Escudero, Rodrigo Bernardo Serafim, Jerusa Smid, Andrea Slachevsky, Cecilia Serrano, Marcio Soto-Anari, Leonel Tadao Takada, Lea Tenenholz Grinberg, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Dominic Trepel, Agustin Ibanez
Summary: In Latin American and Caribbean countries, the fight against dementia faces challenges such as heterogeneity, diversity, political instability, and socioeconomic disparities, which can be addressed more effectively through collaborative efforts that foster open exchange of knowledge.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Pamela J. Urrutia, Felipe Bodaleo, Daniel A. Borquez, Yuta Homma, Victoria Rozes-Salvador, Cristopher Villablanca, Cecilia Conde, Mitsunori Fukuda, Christian Gonzalez-Billault
Summary: The acquisition of neuronal polarity is a complex process depending on cytoskeletal dynamics and membrane traffic regulation. A positive feedback loop between Rab8a and Cdc42, coupled by Tuba, plays a crucial role in ensuring single axon generation. These findings suggest Tuba coordinates vesicular traffic and cytoskeleton dynamics during neuronal polarization.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Sandra A. Nino, Erika Chi-Ahumada, Leticia Carrizales, Ana Maria Estrada-Sanchez, Christian Gonzalez-Billault, Sergio Zarazua, Luis Concha, Maria E. Jimenez-Capdeville
Summary: Research shows that long-term exposure to arsenic can lead to pathological changes in the structure and immunohistochemistry of the hippocampus in rats, including loss of myelin basic protein and increased expression of glial fibrillary acidic protein. This may affect hippocampal connectivity, leading to cognitive impairment.
Article
Biochemistry & Molecular Biology
Danilo Bilches Medinas, Sajid Malik, Esra Yildiz-Bolukbasi, Janina Borgonovo, Mirva J. Saaranen, Hery Urra, Eduardo Pulgar, Muhammad Afzal, Darwin Contreras, Madison T. Wright, Felipe Bodaleo, Gabriel Quiroz, Pablo Rozas, Sara Mumtaz, Rodrigo Diaz, Carlos Rozas, Felipe Cabral-Miranda, Ricardo Pina, Vicente Valenzuela, Ozgun Uyan, Christopher Reardon, Ute Woehlbier, Robert H. Brown, Miguel Sena-Esteves, Christian Gonzalez-Billault, Bernardo Morales, Lars Plate, Lloyd W. Ruddock, Miguel L. Concha, Claudio Hetz, Aslihan Tolun
Summary: A study identified a PDIA3 gene mutation associated with syndromic intellectual disability, leading to developmental defects and abnormal neuronal function. Experimental findings in zebrafish and mice demonstrated the detrimental effects of this mutation, shedding light on the impact of neuronal proteostasis on nervous system function.
Article
Biochemistry & Molecular Biology
Michael Salsaa, Kerestin Aziz, Pablo Lazcano, Michael W. Schmidtke, Maureen Tarsio, Maik Huttemann, Christian A. Reynolds, Patricia M. Kane, Miriam L. Greenberg
Summary: The study found that valproate affects cellular metabolism in yeast by modulating cytosolic pH, leading to increased expression of metabolic genes. These results reveal a central role for pH in regulating the metabolic program of yeast cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mahmoud Suliman, Kendall C. Case, Michael W. Schmidtke, Pablo Lazcano, Chisom J. Onu, Miriam L. Greenberg
Summary: Inositol plays a significant role in cellular function and signaling. Its deficiency can cause cell death and abnormalities in inositol metabolism are associated with human disorders. This study provides a comprehensive understanding of the effects of inositol deprivation on phospholipid metabolism and gene expression in human cells, revealing the essential role of inositol in maintaining cell viability and regulating cell signaling and metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Biochemistry & Molecular Biology
Jiajia Ji, Deena Damschroder, Denise Bessert, Pablo Lazcano, Robert Wessells, Christian A. Reynolds, Miriam L. Greenberg
Summary: Cardiolipin (CL) deficiency is linked to mitochondrial dysfunction and aberrant metabolism in Barth syndrome (BTHS). Abnormal NAD(+) metabolism is observed in BTHS model systems, and supplementation of NAD+ precursors improves mitochondrial function. This could potentially benefit BTHS patients by restoring exercise endurance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Geriatrics & Gerontology
P. Correa-Burrows, R. Burrows, C. Albala, F. A. Court, F. Salech, G. Sanhueza, C. Gonzalez-Billault
Summary: Aging is characterized by a progressive loss of capacities linked to fundamental alterations/damage in multiple cellular and molecular pathways, and obesity has been suggested to accelerate the onset of metabolic imbalances and impact cellular and molecular processes in a manner similar to aging. The study in Chile will investigate how exposure to obesity in critical developmental stages disrupts homeostatic resilience mechanisms and whether early psychosocial adversity influences vulnerability to obesity as a risk factor for accelerated aging. This research may lead to interventions to improve health span in the Chilean population by addressing the contribution of obesity to aging through lifespan from cells to systems.
Review
Neurosciences
Victoria P. San Martin, Anggelo Sazo, Elias Utreras, Gustavo Moraga-Cid, Gonzalo E. Yevenes
Summary: Pharmacological intervention of glycine receptors can restore inhibitory function and exert anti-nociceptive effects on chronic pain. However, the roles of individual subunits of glycine receptors in chronic pain are not well defined.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Dionisio Pedro Amorim Neto, Beatriz Pelegrini Bosque, Joao Vitor Pereira de Godoy, Paulla Vieira Rodrigues, Dario Donoso Meneses, Katiane Tostes, Celisa Caldana Costa Tonoli, Hernandes Faustino de Carvalho, Christian Gonzalez-Billault, Matheus de Castro Fonseca
Summary: This research found a higher abundance of Akkermansia muciniphila in fecal samples of Parkinson's disease patients and showed that the composition of A. muciniphila conditioned medium is influenced by the strain's ability to degrade mucin. Experimental results indicate that bacterial proteins can induce alpha-synuclein aggregation in enteroendocrine cells, but buffering mitochondrial calcium can reverse the damaging effects.
Article
Biochemistry & Molecular Biology
Pablo Lazcano, Michael W. Schmidtke, Chisom J. Onu, Miriam L. Greenberg
Summary: This study demonstrates for the first time that modulation of phosphatidic acid (PA) levels through the AMPK-PLD pathway regulates IP6K1-mediated repression of myo-inositol-3-P synthase (MIPS).
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Neurosciences
Cristopher Villablanca, Rene Vidal, Christian Gonzalez-Billault
Summary: Astrocytes in the Central Nervous System (CNS) play important roles in both normal functioning and disease. Aging leads to reactive astrogliosis and cellular senescence in astrocytes, resulting in harmful proinflammatory effects. The changes in the cytoskeleton of astrocytes, which have not been extensively studied, may contribute to these alterations associated with aging and pathologies.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Pamela J. Urrutia, Christian Gonzalez-Billault
Summary: Neuronal polarization is a complex process regulated by various intrinsic and extrinsic mechanisms. The review summarizes the role of second messengers, such as Ca21, IP3, cAMP, cGMP, and hydrogen peroxide, in controlling different aspects of neuronal polarization. It also highlights the remaining challenges in fully understanding the cellular processes involved in axodendritic polarization.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Claudia Duran-Aniotz, Natalia Poblete, Catalina Rivera-Krstulovic, alvaro O. Ardiles, Mei Li Diaz-Hung, Giovanni Tamburini, Carleen Mae P. Sabusap, Yannis Gerakis, Felipe Cabral-Miranda, Javier Diaz, Matias Fuentealba, Diego Arriagada, Ernesto Munoz, Sandra Espinoza, Gabriela Martinez, Gabriel Quiroz, Pablo Sardi, Danilo B. Medinas, Darwin Contreras, Ricardo Pina, Mychael V. Lourenco, Felipe C. Ribeiro, Sergio T. Ferreira, Carlos Rozas, Bernardo Morales, Lars Plate, Christian Gonzalez-Billault, Adrian G. Palacios, Claudio Hetz
Summary: Alteration in proteostasis network buffering capacity is a new feature of Alzheimer's disease, indicating the presence of endoplasmic reticulum stress. The unfolded protein response (UPR) is the main pathway to deal with ER stress caused by protein folding. Inositol-requiring enzyme-1 (IRE1) serves as a central ER stress sensor, controlling the expression of the transcription factor X-box binding protein 1 (XBP1) to establish adaptive and repair programs. Artificially enhancing the UPR capacity in the AD brain by expressing the active form of XBP1 reduces amyloid deposits and improves synaptic and cognitive function.
Article
Endocrinology & Metabolism
Valerian E. Kagan, Yulia Y. Tyurina, Karolina Mikulska-Ruminska, Deena Damschroder, Eduardo Vieira Neto, Alessia Lasorsa, Alexander A. Kapralov, Vladimir A. Tyurin, Andrew A. Amoscato, Svetlana N. Samovich, Austin B. Souryavong, Haider H. Dar, Abu Ramim, Zhuqing Liang, Pablo Lazcano, Jiajia Ji, Michael W. Schmidtke, Kirill Kiselyov, Aybike Korkmaz, Georgy K. Vladimirov, Margarita A. Artyukhova, Pushpa Rampratap, Laura K. Cole, Ammanamanchi Niyatie, Emma-Kate Baker, Jim Peterson, Grant M. Hatch, Jeffrey Atkinson, Jerry Vockley, Bernhard Kuehn, Robert Wessells, Patrick C. A. van der Wel, Ivet Bahar, Huelya Bayir, Miriam L. Greenberg
Summary: Barth syndrome (BTHS) is a life-threatening genetic disorder caused by mutations in TAFAZZIN (TAZ) gene, leading to abnormal remodeling of mitochondrial cardiolipin (CL). Accumulation of mono-lyso-CL (MLCL) can form peroxidase complex with cytochrome c (cyt c), resulting in increased peroxidation of lipids. This study provides mechanistic insights into the pathogenesis of BTHS and suggests targeting the MLCL-cyt c peroxidase complex as a potential therapeutic approach.