Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK

(2021) Che-Chia Hsu et al.   MOLECULAR CELL

Valproate activates the Snf1 kinase in Saccharomyces cerevisiae by decreasing the cytosolic pH

(2021) Michael Salsaa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds

(2020) Reika Tei et al.   JOURNAL OF CELL BIOLOGY

Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases

(2020) Antonietta Fazio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Membrane Turnover by Phosphatidic Acid: Cellular Functions and Disease Implications

(2019) Rajan Thakur et al.   Frontiers in Cell and Developmental Biology

The Structure and Function of Acylglycerophosphate Acyltransferase 4/ Lysophosphatidic Acid Acyltransferase Delta (AGPAT4/LPAATδ)

(2019) Mikhail A. Zhukovsky et al.   Frontiers in Cell and Developmental Biology

Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells

(2019) Hui Bao et al.   FASEB JOURNAL

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells

(2018) Hitoshi Endo et al.   Scientific Reports

Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction

(2018) Han Han et al.   MOLECULAR CELL

Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis

(2017) Nawal Kassas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression

(2017) Giada Dogliotti et al.   Nature Communications

Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells

(2016) Wenxi Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

(2016) Qingzhang Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket

(2015) Ramya Ganesan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphatidic acid (PA) increases EGF receptor (EGFR) expression by stabilizing mRNA, inhibiting RNAse-A, and by inhibiting lysosomal and proteasomal degradation of the internalized EGFR

(2015) Nathaniel Hatton et al.   MOLECULAR AND CELLULAR BIOLOGY

Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia

(2014) Michael J. Berridge   CELL AND TISSUE RESEARCH

Phospholipase D and the Maintenance of Phosphatidic Acid Levels for Regulation of Mammalian Target of Rapamycin (mTOR)

(2014) David A. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inositol pyrophosphates: between signalling and metabolism

(2013) Miranda S. C. Wilson et al.   BIOCHEMICAL JOURNAL

Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study

(2013) P. G. Artini et al.   GYNECOLOGICAL ENDOCRINOLOGY

Phosphorylation Regulatesmyo-Inositol-3-phosphate Synthase

(2013) Rania M. Deranieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells

(2013) F. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation

(2013) A. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential methylation of the gene encodingmyo-inositol 3-phosphate synthase (Isyna1) in rat tissues

(2011) Ratnam S Seelan et al.   Epigenomics

Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination

(2010) F. Kassie et al.   CARCINOGENESIS