rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Macrophage Bone Morphogenic Protein Receptor 2 (BMPR2) depletion in Idiopathic Pulmonary Fibrosis (IPF) and Group III Pulmonary Hypertension

(2016) Ning-Yuan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension

(2016) Andrew J. Bryant et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Therapeutic potential of adipose stem cell-derived conditioned medium against pulmonary hypertension and lung fibrosis

(2016) Anandharajan Rathinasabapathy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Classification of Pulmonary Hypertension

(2016) Ronald J. Oudiz   CARDIOLOGY CLINICS

Group III Pulmonary Hypertension

(2016) James R. Klinger   CARDIOLOGY CLINICS

Antagonism of the Thromboxane-Prostanoid Receptor is Cardioprotective against Right Ventricular Pressure Overload

(2016) James D. West et al.   Pulmonary Circulation

Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension

(2016) James D. West et al.   PLoS One

The Angiotensin-Converting Enzyme 2/Angiotensin (1–7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway

(2015) Ying Meng et al.   ANTIOXIDANTS & REDOX SIGNALING

Cerebroprotective effects of RAS inhibitors: Beyond their cardio-renal actions

(2015) Jaspreet Kalra et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Angiotensins as therapeutic targets beyond heart disease

(2015) Danielle Gomes Passos-Silva et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Expression of Mutant Bone Morphogenetic Protein Receptor II Worsens Pulmonary Hypertension Secondary to Pulmonary Fibrosis

(2015) Andrew J. Bryant et al.   Pulmonary Circulation

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Upfront triple combination therapy in pulmonary arterial hypertension: a pilot study

(2014) O. Sitbon et al.   EUROPEAN RESPIRATORY JOURNAL

Diminazene Attenuates Pulmonary Hypertension and Improves Angiogenic Progenitor Cell Functions in Experimental Models

(2013) Vinayak Shenoy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Axis Protects against Lung Fibrosis by Inhibiting the MAPK/NF-κB Pathway

(2013) Ying Meng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages

(2013) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury

(2012) G. J. Rey-Parra et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

(2012) Isis E Fernandez et al.   LANCET

Immune and inflammatory mechanisms in pulmonary arterial hypertension

(2012) Hala El Chami et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension

(2011) Jennifer A. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modeling pulmonary fibrosis with bleomycin

(2011) Marios A. Mouratis et al.   CURRENT OPINION IN PULMONARY MEDICINE

Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology

(2011) YanFei Qi et al.   EXPERIMENTAL PHYSIOLOGY

Manganese superoxide dismutase inhibits neointima formation through attenuation of migration and proliferation of vascular smooth muscle cells

(2011) Jia-Ning Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Renin-Angiotensin-Aldosterone System in Diabetes and Hypertension

(2011) Willa A. Hsueh et al.   Journal of Clinical Hypertension

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

ACE2 Improves Right Ventricular Function in a Pressure Overload Model

(2011) Jennifer A. Johnson et al.   PLoS One

The Angiotensin-Converting Enzyme 2/Angiogenesis-(1–7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension

(2010) Vinayak Shenoy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

Therapeutic Implications of the Vasoprotective Axis of the Renin-Angiotensin System in Cardiovascular Diseases

(2009) Anderson J. Ferreira et al.   HYPERTENSION

Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis

(2008) Xiaopeng Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY