Bergenin, Acting as an Agonist of PPARγ, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-κB-Mediated Macrophage Activation

The natural product bergenin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NF-kappaB activition

(2017) Shengqian Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

The In Vitro and In Vivo Anti-Inflammatory Effects of a Phthalimide PPAR-γ Agonist

(2017) Mingzhi Su et al.   Marine Drugs

Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

(2017) Xiaotian Xu et al.   Cell Death & Disease

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

(2017) Wenjing Luo et al.   Scientific Reports

The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway

(2016) Jiong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Anti-inflammatory protection afforded by cyanidin-3-glucoside and resveratrol in human intestinal cells via Nrf2 and PPAR-γ: Comparison with 5-aminosalicylic acid

(2016) Diana Serra et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sam68 modulates apoptosis of intestinal epithelial cells via mediating NF-κB activation in ulcerative colitis

(2016) Ji Qian et al.   MOLECULAR IMMUNOLOGY

Current approaches for optimizing the benefit of biologic therapy in ulcerative colitis

(2016) M. Anthony Sofia et al.   Therapeutic Advances in Gastroenterology

Sparstolonin B inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes

(2015) Ming Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

The Effects of Armillarisin A on Serum IL-1β and IL-4 and in Treating Ulcerative Colitis

(2014) Ping Wu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis

(2014) Xue-jiao Gao et al.   INFLAMMATION

Peroxisome Proliferator-Activated Receptor-  Regulates the Expression of Alveolar Macrophage Macrophage Colony-Stimulating Factor

(2014) T. L. Bonfield et al.   JOURNAL OF IMMUNOLOGY

Pyrano-isochromanones as IL-6 Inhibitors: Synthesis, in Vitro and in Vivo Antiarthritic Activity

(2014) Shreyans K. Jain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-γ function

(2014) Zun-Jing Liu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ligand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1

(2014) J S Hwang et al.   Cell Death & Disease

PPAR-Gamma in Ulcerative Colitis: A Novel Target for Intervention

(2013) Benjamin Bertin et al.   CURRENT DRUG TARGETS

Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-γ in THP-1-derived macrophages

(2013) Ke Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Down-regulated Peroxisome Proliferator-activated Receptor γ (PPARγ) in Lung Epithelial Cells Promotes a PPARγ Agonist-reversible Proinflammatory Phenotype in Chronic Obstructive Pulmonary Disease (COPD)

(2013) Sowmya P. Lakshmi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

15-Deoxy-Δ12,14-Prostaglandin J2Modulates Lipopolysaccharide-Induced Chemokine Expression by Blocking Nuclear Factor-κB Activation via Peroxisome Proliferator Activated Receptor-γ-Independent Mechanism in Renal Tubular Epithelial Cells

(2013) Ying Lu et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway

(2012) Wei Huang et al.   ACTA PHARMACOLOGICA SINICA

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrated Virtual Screening for the Identification of Novel and Selective Peroxisome Proliferator-Activated Receptor (PPAR) Scaffolds

(2012) Daniel K. Nevin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amorfrutins are potent antidiabetic dietary natural products

(2012) C. Weidner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear receptor PPAR -regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis

(2012) Y. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation

(2011) Massimo Ghizzoni et al.   DRUG DISCOVERY TODAY

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

Cells, cytokines and inflammatory bowel disease: a clinical perspective

(2011) Ian C Roberts-Thomson et al.   Expert Review of Gastroenterology & Hepatology

Topical Rosiglitazone Treatment Improves Ulcerative Colitis by Restoring Peroxisome Proliferator-Activated Receptor-γ Activity

(2010) Gitte Pedersen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction

(2009) Shu-Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Successful treatment of a patient with takayasu arteritis using a humanized anti-interleukin-6 receptor antibody

(2008) Norihiro Nishimoto et al.   ARTHRITIS AND RHEUMATISM

Rosiglitazone for Active Ulcerative Colitis: A Randomized Placebo-Controlled Trial

(2008) James D. Lewis et al.   GASTROENTEROLOGY