Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-06-08
DOI
10.3389/fphar.2018.00588
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability
- (2017) Caroline L. Ring et al. ENVIRONMENT INTERNATIONAL
- Sensitivity analysis of environmental models: A systematic review with practical workflow
- (2016) Francesca Pianosi et al. ENVIRONMENTAL MODELLING & SOFTWARE
- Global Sensitivity Analysis of environmental models: Convergence and validation
- (2016) Fanny Sarrazin et al. ENVIRONMENTAL MODELLING & SOFTWARE
- Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling
- (2016) Todd J. Zurlinden et al. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data
- (2015) Thierry Wendling et al. AAPS Journal
- A global sensitivity analysis approach for morphogenesis models
- (2015) Sonja E. M. Boas et al. BMC Systems Biology
- Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach
- (2015) Todd J. Zurlinden et al. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice
- (2015) Pinpin Lin et al. International Journal of Nanomedicine
- Global sensitivity analysis for urban water quality modelling: Terminology, convergence and comparison of different methods
- (2015) Peter A. Vanrolleghem et al. JOURNAL OF HYDROLOGY
- Identifiability of PBPK models with applications to dimethylarsinic acid exposure
- (2015) Ramon I. Garcia et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system
- (2015) Annie Lumen et al. Frontiers in Pharmacology
- The application of global sensitivity analysis in the development of a physiologically based pharmacokinetic model for m-xylene and ethanol co-exposure in humans
- (2015) George D. Loizou et al. Frontiers in Pharmacology
- Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse
- (2014) Weihsueh A. Chiu et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Better estimation of small sobol' sensitivity indices
- (2013) Art B. Owen ACM Transactions on Modeling and Computer Simulation
- A Physiologically Based Pharmacokinetic Model of Rifampin in Mice
- (2013) Michael A. Lyons et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data
- (2013) Nikolaos Tsamandouras et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Comparison of Nonmem 7.2 estimation methods and parallel processing efficiency on a target-mediated drug disposition model
- (2011) Leonid Gibiansky et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- A Workflow for Global Sensitivity Analysis of PBPK Models
- (2011) Kevin McNally et al. Frontiers in Pharmacology
- Global Sensitivity Analysis for Systems with Independent and/or Correlated Inputs
- (2010) Genyuan Li et al. JOURNAL OF PHYSICAL CHEMISTRY A
- GNU MCSim: Bayesian statistical inference for SBML-coded systems biology models
- (2009) F. Y. Bois BIOINFORMATICS
- Variance based sensitivity analysis of model output. Design and estimator for the total sensitivity index
- (2009) Andrea Saltelli et al. COMPUTER PHYSICS COMMUNICATIONS
- Sensitivity analysis of the rice model WARM in Europe: Exploring the effects of different locations, climates and methods of analysis on model sensitivity to crop parameters
- (2009) Roberto Confalonieri et al. ENVIRONMENTAL MODELLING & SOFTWARE
- Assessing the arsenic-contaminated rice (Oryza sativa) associated children skin lesions
- (2009) Chung-Min Liao et al. JOURNAL OF HAZARDOUS MATERIALS
- Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach
- (2009) Weihsueh A. Chiu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Identification of Intestinal Loss of a Drug through Physiologically Based Pharmacokinetic??Simulation of Plasma??Concentration-Time Profiles
- (2008) Sheila Annie Peters CLINICAL PHARMACOKINETICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started