Single- and Multiple-Dose Trials to Determine the Pharmacokinetics, Safety, Tolerability, and Sex Effect of Oral Ginsenoside Compound K in Healthy Chinese Volunteers

Food and Sex-Related Impacts on the Pharmacokinetics of a Single-Dose of Ginsenoside Compound K in Healthy Subjects

(2017) Lulu Chen et al.   Frontiers in Pharmacology

Ginsenoside metabolite compound K exerts joint-protective effect by interfering with synoviocyte function mediated by TNF-α and Tumor necrosis factor receptor type 2

(2016) Ying Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gene expression kinetics of renal transporters induced by ochratoxin A in male and female F344 rats

(2016) Laura Pastor et al.   FOOD AND CHEMICAL TOXICOLOGY

Screening of Drug Metabolizing Enzymes for the Ginsenoside Compound K In Vitro: An Efficient Anti-Cancer Substance Originating from Panax Ginseng

(2016) Jian Xiao et al.   PLoS One

Interaction of Drug or Food with Drug Transporters in Intestine and Liver

(2015) Takeo Nakanishi et al.   CURRENT DRUG METABOLISM

A review of biotransformation and pharmacology of ginsenoside compound K

(2015) Xi-Ding Yang et al.   FITOTERAPIA

Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis rats

(2014) Huaxun Wu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

Ginsenoside Metabolites Inhibit P-Glycoprotein In Vitro and In Situ Using Three Absorption Models

(2014) Na Li et al.   PLANTA MEDICA

Needed: More Females in Animal and Cell Studies

(2014) J. Couzin-Frankel   SCIENCE

Compound K, an intestinal metabolite of ginsenosides, inhibits PDGF-BB-induced VSMC proliferation and migration through G1 arrest and attenuates neointimal hyperplasia after arterial injury

(2013) Eun-Seok Park et al.   ATHEROSCLEROSIS

Systematic Evaluation of Dose Accumulation Studies in Clinical Pharmacokinetics

(2013) Lujin Li et al.   CURRENT DRUG METABOLISM

Sex differences in cyclosporine pharmacokinetics and ABCB1 gene expression in mononuclear blood cells in African American and Caucasian renal transplant recipients

(2013) Kathleen M. Tornatore et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Development and validation of an LC-MS/MS method for determination of compound K in human plasma and clinical application

(2013) Jung Soo Kim et al.   Journal of Ginseng Research

Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract

(2013) Hyung-Ki Kim   Journal of Ginseng Research

Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer

(2012) Chun-Su Yuan   INTERNATIONAL JOURNAL OF ONCOLOGY

Absorption Mechanism of Ginsenoside Compound K and Its Butyl and Octyl Ester Prodrugs in Caco-2 Cells

(2012) Bing Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation—The key step of inflammation

(2011) Eun-Ha Joh et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacokinetic comparison of ginsenoside metabolite IH-901 from fermented and non-fermented ginseng in healthy Korean volunteers

(2011) Hui Jin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gender-related differences on P-glycoprotein-mediated drug intestinal transport in rats

(2011) Ballent Mariana et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Production of aglycon protopanaxadiol via compound K by a thermostable β-glycosidase from Pyrococcus furiosus

(2010) Mi-Hyun Yoo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Glucocorticoid receptor agonist compound K regulates dectin-1-dependent inflammatory signaling through inhibition of reactive oxygen species

(2009) Trinh Tat Cuong et al.   LIFE SCIENCES

Purification Method Improvement and Characterization of a Novel Ginsenoside-Hydrolyzing β-Glucosidase fromPaecilomyces Bainiersp. 229

(2008) Qin YAN et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats

(2008) C. MacLean et al.   DRUG METABOLISM AND DISPOSITION

Studies on absorption, distribution and metabolism of ginseng in humans after oral administration

(2008) Jayeul Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY