The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research

Storage stability study of porcine hepatic and intestinal cytochrome P450 isoenzymes by use of a newly developed and fully validated highly sensitive HPLC-MS/MS method

(2018) Wim Schelstraete et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs

(2017) Els Van Peer et al.   PHARMACEUTICAL RESEARCH

Constitutive expression and activity of cytochrome P450 in conventional pigs

(2017) Søren Drud Nielsen et al.   RESEARCH IN VETERINARY SCIENCE

The Potential Use of Piglets as Human Pediatric Surrogate for Preclinical Pharmacokinetic and Pharmacodynamic Drug Testing

(2016) Elke Gasthuys et al.   CURRENT PHARMACEUTICAL DESIGN

Specific features of pharmacokinetics in children

(2016) Petra Matalová et al.   DRUG METABOLISM REVIEWS

The effect of the MC4R gene on boar taint compounds, sexual maturity and behaviour in growing-finishing boars and gilts

(2015) A. Van den Broeke et al.   Animal

Age-related Differences in CYP3A Abundance and Activity in the Liver of the Göttingen Minipig

(2015) Els Van Peer et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Content and activity of human liver microsomal protein and prediction of individual hepatic clearance in vivo

(2015) Haifeng Zhang et al.   Scientific Reports

Microsomal protein per gram of liver (MPPGL) in paediatric biliary atresia patients

(2014) Lies De Bock et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics

(2014) C. Gröer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Impact of age on hepatic cytochrome P450 of domestic male Camborough-29 pigs

(2014) S. X. Hu   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

iTRAQ as a method for optimization: Enhancing peptide recovery after gel fractionation

(2014) Pieter Glibert et al.   PROTEOMICS

Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling

(2013) Zoe E. Barter et al.   CLINICAL PHARMACOKINETICS

Xenobiotic Metabolizing Cytochrome P450 in Pig, a Promising Animal Model

(2013) Emanuela Puccinelli et al.   CURRENT DRUG METABOLISM

The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs

(2013) J. Goossens et al.   FOOD AND CHEMICAL TOXICOLOGY

Animal models of toxicology testing: the role of pigs

(2012) Kristi L Helke et al.   Expert Opinion on Drug Metabolism & Toxicology

Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

(2011) B. Achour et al.   DRUG METABOLISM AND DISPOSITION

Role of the cytochrome P450 enzyme system in veterinary pharmacokinetics: where are we now? Where are we going?

(2011) Leposava Antonovic et al.   Future Medicinal Chemistry

Development and validation of a fast and sensitive UPLC–MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity

(2011) Lies De Bock et al.   TALANTA

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Chlorzoxazone Metabolism by Porcine Cytochrome P450 Enzymes and the Effect of Cytochrome b5

(2010) P. Wiercinska et al.   DRUG METABOLISM AND DISPOSITION

Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection

(2010) Hirotaka Kawakami et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Gender-related Differences in Cytochrome P450 in Porcine Liver - Implication for Activity, Expression and Inhibition by Testicular Steroids

(2010) MK Rasmussen et al.   REPRODUCTION IN DOMESTIC ANIMALS

The utility of the minipig as an animal model in regulatory toxicology

(2010) Gerd Bode et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase

(2009) F Peter Guengerich et al.   Nature Protocols

Analyses of CYP2C in Porcine Microsomes

(2008) Mette T. Skaanild et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

(2008) Z. E. Barter et al.   DRUG METABOLISM AND DISPOSITION