Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-05-11
DOI
10.3389/fphar.2018.00474
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Membrane estrogen receptors signal to determine transcription factor function
- (2018) Ellis R. Levin STEROIDS
- The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts
- (2017) Wengui Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IGF-1 signaling mediated cell-specific skeletal mechano-transduction
- (2017) Faming Tian et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- The effect of icariin on bone metabolism and its potential clinical application
- (2017) Z. Wang et al. OSTEOPOROSIS INTERNATIONAL
- Estrogen receptors alpha and beta in bone
- (2016) Aysha B. Khalid et al. BONE
- Icariin Stimulates Differentiation and Suppresses Adipocytic Transdifferentiation of Primary Osteoblasts Through Estrogen Receptor-Mediated Pathway
- (2016) Dawei Zhang et al. CALCIFIED TISSUE INTERNATIONAL
- Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors
- (2016) Ellis R. Levin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii
- (2015) Chenrui Li et al. LIFE SCIENCES
- Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity
- (2015) Tao Hu et al. PHYTOMEDICINE
- Icariin recovers the osteogenic differentiation and bone formation of bone marrow stromal cells from a rat model of estrogen deficiency-induced osteoporosis
- (2015) ZHIQIANG LUO et al. Molecular Medicine Reports
- Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts and preserves their osteogenic differentiation potentialin vitro
- (2014) H.-P. Ma et al. CELL PROLIFERATION
- Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERα) and stimulate ER-dependent osteoblastic functions in UMR-106 cells
- (2014) Hui-Hui Xiao et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER–ERK–mTOR pathway
- (2013) Yue-Hua Yang et al. APOPTOSIS
- Genistein induces oestrogen receptor-α gene expression in osteoblasts through the activation of mitogen-activated protein kinases/NF-κB/activator protein-1 and promotes cell mineralisation
- (2013) Mei-Hsiu Liao et al. BRITISH JOURNAL OF NUTRITION
- Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation
- (2013) Lige Song et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro
- (2013) HUIFANG ZHOU et al. Molecular Medicine Reports
- Recent insights into non-nuclear actions of estrogen receptor alpha
- (2013) Subhashis Banerjee et al. STEROIDS
- Soy Isoflavones and Cardiovascular Disease Epidemiological, Clinical and -Omics Perspectives
- (2012) A. Gil-Izquierdo et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line
- (2012) WENNA LIANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling
- (2012) Lei-Guo Ming et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The pros and cons of plant estrogens for menopause
- (2012) Sarah Bedell et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Phytoestrogens for menopausal bone loss and climacteric symptoms
- (2012) Violet S. Lagari et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- IGF-I/PI3K/Akt and IGF-I/MAPK/ERK pathways in vivo in skeletal muscle are regulated by nutrition and contribute to somatic growth in the fine flounder
- (2011) Eduardo N. Fuentes et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Icariin stimulates MC3T3-E1 cell proliferation and differentiation through up-regulation of bone morphogenetic protein-2
- (2011) Ying Zhang INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis
- (2011) H. M. Zhu et al. OSTEOPOROSIS INTERNATIONAL
- Phytoestrogens and bone health
- (2011) Violet S Lagari et al. Current Opinion in Endocrinology Diabetes and Obesity
- Total flavonoid fraction of the Herba epimedii extract suppresses urinary calcium excretion and improves bone properties in ovariectomised mice
- (2010) Wen-Fang Chen et al. BRITISH JOURNAL OF NUTRITION
- Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells
- (2010) Wai-Yin Pang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells
- (2010) Sao-Keng Mok et al. BRITISH JOURNAL OF PHARMACOLOGY
- Icariin attenuates LPS-induced acute inflammatory responses: Involvement of PI3K/Akt and NF-κB signaling pathway
- (2010) Chang-Qing Xu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro
- (2010) Hui-Ping Ma et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling
- (2009) Andrew Sunters et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Apoptosis in Bone for Tissue Engineering
- (2008) Gregor M. Bran et al. ARCHIVES OF MEDICAL RESEARCH
- Osteogenic activities of genistein derivatives were influenced by the presence of prenyl group at ring a
- (2008) Yan Zhang et al. ARCHIVES OF PHARMACAL RESEARCH
- Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner
- (2008) Jiyuan Zhao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action
- (2008) Raewyn C Poulsen et al. NUTRITION REVIEWS
- Soy isoflavones and their bone protective effects
- (2008) Y. Zhang et al. INFLAMMOPHARMACOLOGY
- PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells
- (2007) Soo-Jin Jeong et al. VIROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started