Hedonic Eating and the “Delicious Circle”: From Lipid-Derived Mediators to Brain Dopamine and Back

Impact of Dietary Fats on Brain Functions

(2018) Rosanna Chianese et al.   Current Neuropharmacology

Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat

(2017) Roberto Coccurello et al.   EUROPEAN JOURNAL OF NUTRITION

Oleic Acid in the Ventral Tegmental Area Inhibits Feeding, Food Reward, and Dopamine Tone

(2017) Cecile Hryhorczuk et al.   NEUROPSYCHOPHARMACOLOGY

Central insulin modulates food valuation via mesolimbic pathways

(2017) Lena J. Tiedemann et al.   Nature Communications

Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice

(2017) Thorsten Michael Becker et al.   Molecular Metabolism

Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity

(2016) A M Monteleone et al.   EUROPEAN JOURNAL OF NUTRITION

Ghrelin enhances cue-induced bar pressing for high fat food

(2016) Veronique St-Onge et al.   HORMONES AND BEHAVIOR

Feeding and Reward Are Differentially Induced by Activating GABAergic Lateral Hypothalamic Projections to VTA

(2016) M. F. Barbano et al.   JOURNAL OF NEUROSCIENCE

Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation

(2016) Edward H. Nieh et al.   NEURON

Consumption of palatable food primes food approach behavior by rapidly increasing synaptic density in the VTA

(2016) Shuai Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

(2016) Li-Wei Tung et al.   Nature Communications

Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward

(2016) M Shen et al.   Translational Psychiatry

Role of the satiety factor oleoylethanolamide in alcoholism

(2015) Ainhoa Bilbao et al.   ADDICTION BIOLOGY

Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents

(2015) Miki Igarashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats

(2015) Christina J. Reppucci et al.   Brain Structure & Function

Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors

(2015) Joshua H. Jennings et al.   CELL

Negative Regulation of Leptin-induced Reactive Oxygen Species (ROS) Formation by Cannabinoid CB1Receptor Activation in Hypothalamic Neurons

(2015) Letizia Palomba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin regulates phasic dopamine and nucleus accumbens signaling evoked by food-predictive stimuli

(2015) Jackson J. Cone et al.   JOURNAL OF NEUROCHEMISTRY

Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders

(2015) Olivia M. Farr et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Endocannabinoid signalling in reward and addiction

(2015) Loren H. Parsons et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior

(2015) Samantha Mancino et al.   NEUROPSYCHOPHARMACOLOGY

Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids

(2015) Cecile Hryhorczuk et al.   NEUROPSYCHOPHARMACOLOGY

Ghrelin signaling in the ventral tegmental area mediates both reward-based feeding and fasting-induced hyperphagia on high-fat diet

(2015) X.J. Wei et al.   NEUROSCIENCE

Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus

(2015) Fatemeh Yazdi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area

(2015) Huikun Wang et al.   Cell Reports

Anticipatory and consummatory effects of (hedonic) chocolate intake are associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults

(2015) Antonello E. Rigamonti et al.   Food & Nutrition Research

Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food

(2014) Anthony P Goldstone et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Role of the Endocannabinoid System in Eating Disorders: Neurochemical and Behavioural Preclinical Evidence

(2014) Maria Scherma et al.   CURRENT PHARMACEUTICAL DESIGN

Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity

(2014) Ania M. Jastreboff et al.   DIABETES CARE

Ghrelin Acts as an Interface between Physiological State and Phasic Dopamine Signaling

(2014) J. J. Cone et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoid signaling and food addiction

(2014) C. D’Addario et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding

(2014) Nicole Speed et al.   PLoS One

Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake

(2014) G. Provensi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oleoylethanolamide: A Novel Potential Pharmacological Alternative to Cannabinoid Antagonists for the Control of Appetite

(2014) Adele Romano et al.   Biomed Research International

Oleoylethanolamide and Human Neural Responses to Food Stimuli in Obesity

(2014) Martin Grosshans et al.   JAMA Psychiatry

Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell

(2014) Maria Antonietta De Luca et al.   Frontiers in Psychiatry

A clinical approach to the assessment and management of co-morbid eating disorders and substance use disorders

(2013) Claire Gregorowski et al.   BMC Psychiatry

Lipid sensing in the brain and regulation of energy balance

(2013) V.-S. Moullé et al.   DIABETES & METABOLISM

Effect of dietary fatty acid composition on substrate utilization and body weight maintenance in humans

(2013) Sridevi Krishnan et al.   EUROPEAN JOURNAL OF NUTRITION

Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats

(2013) Nicholas V. DiPatrizio et al.   FASEB JOURNAL

Dietary Linoleic Acid Elevates the Endocannabinoids 2-AG and Anandamide and Promotes Weight Gain in Mice Fed a Low Fat Diet

(2013) Anita Røyneberg Alvheim et al.   LIPIDS

Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids

(2013) Gwenaël Labouèbe et al.   NATURE NEUROSCIENCE

The use of the reinstatement model to study relapse to palatable food seeking during dieting

(2013) Donna J. Calu et al.   NEUROPHARMACOLOGY

Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons

(2013) L. Cristino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gastroenteric hormone responses to hedonic eating in healthy humans

(2013) Palmiero Monteleone et al.   PSYCHONEUROENDOCRINOLOGY

A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency

(2013) L. A. Tellez et al.   SCIENCE

A fatty gut feeling

(2013) Daniele Piomelli   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effect of insulin on excitatory synaptic transmission onto dopamine neurons of the ventral tegmental area in a mouse model of hyperinsulinemia

(2013) S Liu et al.   Nutrition & Diabetes

Leptin signaling and leptin resistance

(2013) Yingjiang Zhou et al.   Frontiers of Medicine

Ghrelin increases the motivation to eat, but does not alter food palatability

(2012) Joost Overduin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling

(2012) Scott E. Kanoski et al.   BIOLOGICAL PSYCHIATRY

Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats

(2012) M Scherma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake

(2012) Dmitry. M. Mebel et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Hedonic Eating Is Associated with Increased Peripheral Levels of Ghrelin and the Endocannabinoid 2-Arachidonoyl-Glycerol in Healthy Humans: A Pilot Study

(2012) Palmiero Monteleone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

(2012) Joel D. Hahn et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters

(2012) Reilly T. Enos et al.   JOURNAL OF LIPID RESEARCH

Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism

(2012) Chung Thong Lim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

(2012) Andras Kern et al.   NEURON

Does Food Addiction Exist? A Phenomenological Discussion Based on the Psychiatric Classification of Substance-Related Disorders and Addiction

(2012) Özgür Albayrak et al.   Obesity Facts

Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling

(2012) Angela K. Walker et al.   PHYSIOLOGY & BEHAVIOR

Hypothalamic 2-Arachidonoylglycerol Regulates Multistage Process of High-Fat Diet Preferences

(2012) Sei Higuchi et al.   PLoS One

The endocannabinoid system: an overview

(2012) Natalia Battista et al.   Frontiers in Behavioral Neuroscience

Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression

(2011) Karolina P. Skibicka et al.   ADDICTION BIOLOGY

Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats

(2011) Adrie W. Bruijnzeel et al.   BEHAVIOURAL BRAIN RESEARCH

Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

(2011) S.J. King et al.   HORMONES AND BEHAVIOR

Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity

(2011) B Gatta-Cherifi et al.   INTERNATIONAL JOURNAL OF OBESITY

Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior

(2011) A. R. Adamantidis et al.   JOURNAL OF NEUROSCIENCE

The role of the central ghrelin system in reward from food and chemical drugs

(2011) Suzanne L. Dickson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Leptin regulates the reward value of nutrient

(2011) Ana I Domingos et al.   NATURE NEUROSCIENCE

Common cellular and molecular mechanisms in obesity and drug addiction

(2011) Paul J. Kenny   NATURE REVIEWS NEUROSCIENCE

Impulsivity, Compulsivity, and Top-Down Cognitive Control

(2011) Jeffrey W. Dalley et al.   NEURON

Endocannabinoid-mediated synaptic plasticity and addiction-related behavior

(2011) Nimish Sidhpura et al.   NEUROPHARMACOLOGY

Cannabinoid facilitation of behavioral and biochemical hedonic taste responses

(2011) M.A. De Luca et al.   NEUROPHARMACOLOGY

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates

(2011) Wilmon F. Grant et al.   PLoS One

Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system

(2010) Elisabet Jerlhag et al.   ADDICTION BIOLOGY

The Endocannabinoid System and Its Relevance for Nutrition

(2010) Mauro Maccarrone et al.   Annual Review of Nutrition

Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors

(2010) Sei Higuchi et al.   BEHAVIOURAL BRAIN RESEARCH

Chemical stimulation of the lateral hypothalamus induces conditioned place preference in rats: Involvement of OX1 and CB1 receptors in the ventral tegmental area

(2010) Zahra Taslimi et al.   BEHAVIOURAL BRAIN RESEARCH

Enzymological studies on the biosynthesis of N-acylethanolamines

(2010) Natsuo Ueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement

(2010) Ruth Sharf et al.   BIOLOGICAL PSYCHIATRY

Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits

(2010) Jon F. Davis et al.   BIOLOGICAL PSYCHIATRY

Blockade of Nicotine Reward and Reinstatement by Activation of Alpha-Type Peroxisome Proliferator-Activated Receptors

(2010) Paola Mascia et al.   BIOLOGICAL PSYCHIATRY

Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain

(2010) Harald S. Hansen   EXPERIMENTAL NEUROLOGY

Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma

(2010) JodiAnne T. Wood et al.   JOURNAL OF LIPID RESEARCH

Brain-Derived Neurotrophic Factor Regulates Hedonic Feeding by Acting on the Mesolimbic Dopamine System

(2010) J. W. Cordeira et al.   JOURNAL OF NEUROSCIENCE

The Fat-Induced Satiety Factor Oleoylethanolamide Suppresses Feeding through Central Release of Oxytocin

(2010) S. Gaetani et al.   JOURNAL OF NEUROSCIENCE

Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

(2010) Paul M Johnson et al.   NATURE NEUROSCIENCE

The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats

(2010) D.L. Choi et al.   NEUROSCIENCE

Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity

(2010) Angie M. Cason et al.   PHYSIOLOGY & BEHAVIOR

Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice

(2010) Jon F. Davis et al.   PHYSIOLOGY & BEHAVIOR

Effects of the increase in neuronal fatty acids availability on food intake and satiety in mice

(2010) Roberto Coccurello et al.   PSYCHOPHARMACOLOGY

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

(2010) Elisabet Jerlhag et al.   PSYCHOPHARMACOLOGY

Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

(2010) F. Kasanetz et al.   SCIENCE

Intracellular trafficking of anandamide: new concepts for signaling

(2010) Mauro Maccarrone et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reward, dopamine and the control of food intake: implications for obesity

(2010) Nora D. Volkow et al.   TRENDS IN COGNITIVE SCIENCES

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH

(2009) Makoto Mizutani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

Natural Addiction

(2009) Bartley G. Hoebel et al.   Journal of Addiction Medicine

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Cannabinoid in the nucleus accumbens enhances the intake of palatable solution

(2009) Yuhei Shinohara et al.   NEUROREPORT

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding

(2008) Alexandra Shapiro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Insulin, leptin, and food reward: update 2008

(2008) Dianne P. Figlewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine

(2008) Andreas Artmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Leptin signaling in brain: A link between nutrition and cognition?

(2008) Christopher D. Morrison   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

(2008) Saima Malik et al.   Cell Metabolism

Evidence for the intracellular accumulation of anandamide in adiposomes

(2008) S. Oddi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endogenous Fatty Acid Ethanolamides Suppress Nicotine-Induced Activation of Mesolimbic Dopamine Neurons through Nuclear Receptors

(2008) M. Melis et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons

(2008) B. Pan et al.   JOURNAL OF NEUROSCIENCE

Chronic social stress, hedonism and vulnerability to obesity: Lessons from Rodents

(2008) Roberto Coccurello et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One

Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus

(2007) E Soria-Gómez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area

(2007) Ferenc Mátyás et al.   NEUROPHARMACOLOGY