Review
Immunology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Antonio H. Iglesias, Jean Pierre Schatzmann Peron
Summary: Neuroinflammatory and neurodegenerative diseases are major public health issues worldwide, with mitochondrial dysfunction playing a significant role. Regulation of mitochondrial dynamics is essential for CNS health maintenance, impacting the development and progression of neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Hussain Ahmed Chowdhury, Dhruba Kumar Bhattacharyya, Jugal Kumar Kalita
Summary: This paper proposes an effective clustering method for scRNA-seq data, which integrates preprocessing steps and robust cell group identification. The method requires no user input, except for setting thresholds, and outperforms most other existing methods.
KNOWLEDGE-BASED SYSTEMS
(2022)
Article
Biology
Hussain Ahmed Chowdhury, Dhruba Kumar Bhattacharyya, Jugal Kumar Kalita
Summary: scRNA-seq data analysis allows for identification of novel cells, specific characterization of known cells, and study of cell heterogeneity. Most clustering methods are influenced by user input, but UICPC shows excellent performance without requiring user input.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: Analysis of protein shapes reveals unexpected forms and connections.
Review
Pharmacology & Pharmacy
Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Michael F. McDermott
Summary: The prevalence of neurodegenerative diseases is increasing, characterized by progressive neuronal loss, protein aggregation, metabolic abnormalities, and immune dysregulation. Research has shown that low-grade systemic inflammation may impact the development and progression of these diseases, and inflammation may also be a causative factor.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Jeffrey A. Farrell
Summary: CellOracle, a computational tool, can predict the interaction of gene networks in programming cell identity during embryonic development. This tool will contribute to a better understanding of the regulation of development.
Editorial Material
Multidisciplinary Sciences
Luke M. M. Evans, Pamela N. Romero N. Villela
Summary: An analysis of rare genetic variants shows their impact on human traits is mediated through similar biological pathways as common variants, enhancing our understanding of their influence on complex traits.
Editorial Material
Multidisciplinary Sciences
Roser Vento-Tormo, Roser Vilarrasa-Blasi
Summary: The HuBMAP consortium has created spatially resolved cell atlases for the human intestine, kidney, and placenta, providing unprecedented detail for analyzing tissue organization.
News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: Microbial molecules from soil, seawater, and human bodies are among the least understood substances on Earth.
Article
Biology
Shudong Wang, Yu Zhang, Yulin Zhang, Wenhao Wu, Lan Ye, Yunyin Li, Jionglong Su, Shanchen Pang
Summary: Single-cell RNA sequencing (scRNA-seq) is a successful technique for identifying cellular heterogeneity. In this study, an unsupervised clustering method called scASGC is proposed, which outperforms classical and state-of-the-art methods, and is able to accurately identify cell subpopulations.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xia Liu, Minghui Wang, Ao Li
Summary: This study introduces a novel deep-learning framework called PhosVarDeep for predicting phospho-variants, which significantly improves prediction performance through two identical subnetworks and a prediction module. The experimental results demonstrate the effectiveness of this method and its favorable comparison with existing conventional machine learning methods.
Article
Neurosciences
Zubo Wu, Suyuan Wu, Tao Liang, Lin Wang
Summary: The study found that the level of Lp-PLA2 in PD patients is significantly higher, and positively correlated with the severity of the disease. Lp-PLA2 may be an independent risk factor for PD and can be used as a target for early detection and clinical intervention.
FRONTIERS IN NEUROSCIENCE
(2021)
News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: Two years later, following DeepMind's game-changing AI victory in predicting protein structures, researchers are further advancing their studies based on the success of AlphaFold.
Editorial Material
Multidisciplinary Sciences
Michael Eisenstein
Summary: Deep-learning algorithms are now able to predict a protein's 3D shape from its linear sequence, which is a significant advancement for structural biologists.
Editorial Material
Multidisciplinary Sciences
David A. Leopold
Summary: The human brain's motor cortex is traditionally seen as a linear map controlling different body parts. However, the discovery of additional functions suggests a different kind of mapping.
Article
Genetics & Heredity
Andrew G. Hoss, Adam Labadorf, Jeanne C. Latourelle, Vinay K. Kartha, Tiffany C. Hadzi, James F. Gusella, Marcy E. MacDonald, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Jean Paul Vonsattel, Richard H. Myers
BMC MEDICAL GENOMICS
(2015)
Article
Genetics & Heredity
Alexandra Dumitriu, Javad Golji, Adam T. Labadorf, Benbo Gao, Thomas G. Beach, Richard H. Myers, Kenneth A. Longo, Jeanne C. Latourelle
BMC MEDICAL GENOMICS
(2016)
Article
Biotechnology & Applied Microbiology
Christian Wake, Adam Labadorf, Alexandra Dumitriu, Andrew G. Hoss, Joli Bregu, Kenneth H. Albrecht, Anita L. DeStefano, Richard H. Myers
Article
Geriatrics & Gerontology
Andrew G. Hoss, Adam Labadorf, Thomas G. Beach, Jeanne C. Latourelle, Richard H. Myers
FRONTIERS IN AGING NEUROSCIENCE
(2016)
Article
Biotechnology & Applied Microbiology
Adam Labadorf, Alicia Link, Mark F. Rogers, Julie Thomas, Anireddy S. N. Reddy, Asa Ben-Hur
Article
Multidisciplinary Sciences
Dale N. Richardson, Mark F. Rogers, Adam Labadorf, Asa Ben-Hur, Hui Guo, Andrew H. Paterson, Anireddy S. N. Reddy
Article
Multidisciplinary Sciences
Adam T. Labadorf, Richard H. Myers
Article
Multidisciplinary Sciences
Adam Labadorf, Andrew G. Hoss, Valentina Lagomarsino, Jeanne C. Latourelle, Tiffany C. Hadzi, Joli Bregu, Marcy E. MacDonald, James F. Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Richard H. Myers
Article
Multidisciplinary Sciences
Xianjun Dong, Junko Tsuji, Adam Labadorf, Panos Roussos, Jiang-Fan Chen, Richard H. Myers, Schahram Akbarian, Zhiping Weng
Article
Multidisciplinary Sciences
Christopher W. Ng, Ferah Yildirim, Yoon Sing Yap, Simona Dalin, Bryan J. Matthews, Patricio J. Velez, Adam Labadorf, David E. Housman, Ernest Fraenkel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Cell Biology
Kinyui Alice Lo, Adam Labadorf, Norman J. Kennedy, Myoung Sook Han, Yoon Sing Yap, Bryan Matthews, Xiaofeng Xin, Lei Sun, Roger J. Davis, Harvey F. Lodish, Ernest Fraenkel
Article
Biochemical Research Methods
Shao-Shan Carol Huang, David C. Clarke, Sara J. C. Gosline, Adam Labadorf, Candace R. Chouinard, William Gordon, Douglas A. Lauffenburger, Ernest Fraenkel
PLOS COMPUTATIONAL BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Maria Dafne Cardamone, Joseph Orofino, Adam Labadorf, Valentina Perissi
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Biochemical Research Methods
Seung Hoan Choi, Adam T. Labadorf, Richard H. Myers, Kathryn L. Lunetta, Josee Dupuis, Anita L. DeStefano
BMC BIOINFORMATICS
(2017)