Article
Medicine, Research & Experimental
Min Xu, Wenhua Wang, Wei Lu, Xiaoyang Ling, Qin Rui, Haibo Ni
Summary: This study demonstrates that evodiamine (Evo) improves outcomes after traumatic brain injury (TBI) by targeting the PGK1/NRF2 signaling pathway to regulate oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Ziheng Wang, Zhichao Lu, Yixun Chen, Chenxing Wang, Peipei Gong, Rui Jiang, Qianqian Liu
Summary: The aim of this study was to evaluate the effect of epicatechin on neurological recovery and neuroinflammation after traumatic brain injury (TBI) and investigate its potential value in clinical practice. A TBI model was established in adult rats, and the effect of epicatechin was assessed. The results showed that administering epicatechin after TBI prevented neuronal death, reduced neuroinflammation, and promoted neurological function restoration in TBI rats. A network pharmacology study suggested that epicatechin may exert its therapeutic benefits through the AKT-P53/CREB pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Changmeng Cui, Changshui Wang, Feng Jin, Mengqi Yang, Lingsheng Kong, Wenxiu Han, Pei Jiang
Summary: The study revealed that calcitriol can alleviate oxidative damage induced by TBI by promoting autophagy and activating Nrf2 signaling. Furthermore, treatment with chloroquine (CQ) and genetic knockout of Nrf2 both eliminated the protective effects of calcitriol against TBI-induced neurological deficits and neuronal apoptosis.
MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Esraa Shosha, Rami A. Shahror, Carol A. Morris, Zhimin Xu, Rudolf Lucas, Meghan E. McGee-Lawrence, Nancy J. Rusch, Ruth B. Caldwell, Abdelrahman Y. Fouda
Summary: This study found that the enzyme arginase 1 (A1) exerts its anti-inflammatory effect in macrophages through ODC-mediated suppression of histone deacetylase 3 (HDAC3) and interleukin 1 beta (IL-1 beta). This may provide new strategies for the treatment of retinal ischemic diseases.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Yuanda Zhang, Jin Lan, Dongxu Zhao, Cijie Ruan, Jue Zhou, Haoyuan Tan, Yinghui Bao
Summary: The study found that NTN1 levels increased after TBI, and it had a neuroprotective effect by inhibiting ferroptosis through activation of the UNC5B/Nrf2 pathway. These findings may provide new strategies for the treatment of TBI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Young-Sun Lee, Deepak Prasad Gupta, Sung Hee Park, Hyun-Jeong Yang, Gyun Jee Song
Summary: The study found that DMF can inhibit nitric oxide and proinflammatory cytokine production in microglia, induce microglial switching to the M2 state, increase the expression levels of autophagy markers such as LC3 and ATG7, and promote the formation of autophagosomes. These results suggest that DMF induces autophagy in microglia and its anti-inflammatory effects are partially mediated through an autophagy-dependent pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Xu, Liu Li, Hua Liu, Wei Lu, Xiaoyang Ling, Mingjie Gong
Summary: Rutaecarpine may activate the PGK1/KEAP1/NRF2 pathway to counteract oxidative damage in traumatic brain injury (TBI) neurons. It improves cognitive dysfunction, increases antioxidant capacity, and reduces apoptosis in brain tissue.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiaoyan Feng, Weiwei Ma, Jie Zhu, Wei Jiao, Yuhai Wang
Summary: The study demonstrated that DEX can improve neurological outcomes in TBI mice by inhibiting autophagy and neuroinflammation, enhancing neuron survival, and reducing the expression of pro-inflammatory cytokines and autophagy-related proteins. The neuroprotective effect of DEX is partially mediated through the ROS/nuclear factor erythroid 2-related factor 2 signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Chemistry, Medicinal
Lulu Li, Yan Lan, Fuqian Wang, Tiexiang Gao
Summary: Linarin prevents acute liver injury by alleviating oxidative stress, inhibiting inflammatory responses, and promoting autophagic flux.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Hai-Ping Gu, Xiao-Feng Wu, Ya-Ting Gong, Mu-Yao Wu, Meng-Ying Shi, Ya-ming Sun, Bao-Qi Dang, Gang Chen
Summary: The role of HDAC3 in surgical brain injury (SBI) was studied and it was found that inhibiting HDAC3 can reduce oxidative stress and neuronal apoptosis, thereby reducing brain edema and protecting against nerve injury.
Article
Pharmacology & Pharmacy
Juliana M. Rosa, Victor Farre-Alins, Maria Cristina Ortega, Marta Navarrete, Ana Belen Lopez-Rodriguez, Alejandra Palomino-Antolin, Elena Fernandez-Lopez, Virginia Vila-del Sol, Celine Decouty, Paloma Narros-Fernandez, Diego Clemente, Javier Egea
Summary: The activation of astrocytes through the TLR4 pathway following TBI leads to detrimental effects on synapses and cerebrovascular integrity. Pharmacological blockage of TLR4 pathway partially reverses these effects, while astrocytic-protein thrombospondin-1 plays a role in inducing synaptic recovery in the sub-acute phase post-TBI.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Lin Cai, Qiuyuan Gong, Lin Qi, Tongtong Xu, Qian Suo, Xiang Li, Wei Wang, Yao Jing, Dianxu Yang, Zhiming Xu, Fang Yuan, Yaohui Tang, Guoyuan Yang, Jun Ding, Hao Chen, Hengli Tian
Summary: This study found that ACT001 can alleviate neurodegeneration after TBI by reducing the activation of microglia cells. ACT001 can inhibit the production of pro-inflammatory cytokines induced by LPS, improve cellular apoptosis and tube formation, and its mechanism of action is related to the AKT/NF kappa B/NLRP3 pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Jianqin Xue, Yu Zhang, Junhua Zhang, Zhujun Zhu, Qi Lv, Jianhua Su
Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhouxia Luo, Qin Wan, Yanmin Han, Zhubo Li, Boheng Li
Summary: The study found that CAPE-pNO2 could reduce diabetic brain atrophy and decrease the number of cells in the hippocampus and cerebral cortex. Additionally, CAPE-pNO2 could lower the expression of Aβ and p-tau (S396) through antioxidation, anti-inflammation, and autophagy induction in vivo. Furthermore, CAPE-pNO2 could down-regulate the expression of p-tau (S396) through Nrf2-related antioxidation mechanisms in vitro.
Article
Neurosciences
Leilei Mao, Limin Sun, Jingyi Sun, Baoliang Sun, Yanqin Gao, Hong Shi
Summary: The study demonstrates that EP treatment can improve sensorimotor function following TBI, reduce white matter injury, and modulate microglia polarization toward the anti-inflammatory M2 phenotype during the acute phase of TBI recovery, improving the release of inflammatory-related factors.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Maoxing Fei, Handong Wang, Mengliang Zhou, Chulei Deng, Li Zhang, Yanling Han
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Renxin Yi, Handong Wang, Chulei Deng, Xinyue Wang, Lei Yao, Wenhao Niu, Maoxing Fei, Wangdui Zhaba
BIOSCIENCE REPORTS
(2020)
Article
Neurosciences
Li Zhang, Maoxing Fei, Handong Wang, Yihao Zhu
BRAIN RESEARCH BULLETIN
(2020)
Article
Immunology
Han Wang, Xiao-Ming Zhou, Ling-Yun Wu, Guang-Jie Liu, Wei-Dong Xu, Xiang-Sheng Zhang, Yong-Yue Gao, Tao Tao, Yan Zhou, Yue Lu, Juan Wang, Chu-Lei Deng, Zong Zhuang, Chun-Hua Hang, Wei Li
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Oncology
Yong Wu, Wuting Wei, Linjun Tang, Liangwei Wang
Article
Oncology
Maoxing Fei, Li Zhang, Handong Wang, Yihao Zhu, Wenhao Niu, Ting Tang, Yanling Han
FRONTIERS IN ONCOLOGY
(2020)
Article
Clinical Neurology
Qiang Wang, Han-Dong Wang, Wenhao Niu, Hao Pan
Summary: This study evaluated the prognostic significance of IDH1/2 mutation, 1p/19q codeletion, and MGMT promoter methylation in lower-grade gliomas according to the 2016 WHO classification. Various factors such as age, mutation status were found to be associated with patient outcomes, with single tumor, MGMT promoter methylation, and chemoradiotherapy identified as independent prognostic factors for overall survival.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Correction
Oncology
Jianhong Zhu, Handong Wang, Qing Sun, Xiangjun Ji, Lin Zhu, Zixiang Cong, Yuan Zhou, Huandong Liu, Mengliang Zhou
Article
Biochemistry & Molecular Biology
Ting Tang, Handong Wang, Yanling Han, Hanyu Huang, Wenhao Niu, Maoxing Fei, Yihao Zhu
Summary: The NDRG family plays an important role in glioma, with differential expression potentially impacting patient prognosis and tumor grade. Additionally, NDRGs may be crucial in signal transduction, energy metabolism, and intercellular communication in glioma.
DNA AND CELL BIOLOGY
(2021)
Article
Neurosciences
Jiakai Chen, Handong Wang, Junjun Wang, Wenhao Niu, Chulei Deng, Mengliang Zhou
Summary: Accumulated evidence suggests that NEAT1 promotes glioma progression by acting as a sponge for miR-128-3p. The NEAT1/miR-128-3p/ITGA5 axis is involved in glioma initiation and progression, offering a potential novel strategy for treatment. NEAT1 competitively binds to miR-128-3p to enhance ITGA5 expression, activating the FAK signaling pathway and promoting cell growth in glioma.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, General & Internal
Li-Li Wen, Xiao-Ming Zhou, Sheng-Yin Lv, Jiang Shao, Han-Dong Wang, Xin Zhang
Summary: High-grade aneurysmal subarachnoid hemorrhage is a severe disease with a poor prognosis, where elevated intracranial pressure is a major feature leading to secondary brain injury. This study suggests that a combination therapy of early coiling and subsequent ventricular intracranial pressure monitoring may benefit high-grade patients, with most patients surviving and intracranial pressure maintained within normal range. Delayed cerebral ischemia and Glasgow coma scale were significant predictors of outcome.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Neurosciences
Chulei Deng, Renxin Yi, Maoxing Fei, Tao Li, Yanling Han, Handong Wang
Summary: Traumatic brain injury (TBI) is a major cause of disability and death globally, with accumulating evidence suggesting that endoplasmic reticulum (ER) stress plays a crucial role in its pathogenesis. Naringenin, a natural flavonoid, has been shown to ameliorate TBI-induced secondary brain injury by attenuating ER stress, oxidative stress, and apoptosis, indicating its potential for neuroprotective effects in TBI.
Article
Biochemistry & Molecular Biology
Sheng-Qing Gao, Jia-Jun Shi, Shu-Hao Miao, Tao Li, Chao-Chao Gao, Yan-Ling Han, Jia-Yin Qiu, Yun-Song Zhuang, Meng-Liang Zhou
Summary: This study investigated the contribution of the interaction between endothelial NOX4 and DHFR to eNOS uncoupling after SAH. Inhibiting endothelial NOX4 and increasing endothelial DHFR levels alleviated eNOS uncoupling and improved neurological function after SAH.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Hao Cheng, Guangfu Di, Chao-Chao Gao, Guoyuan He, Xue Wang, Yan-Ling Han, Le-an Sun, Meng-Liang Zhou, Xiaochun Jiang
Summary: The study evaluated the effects of the S1PR1 modulator FTY720 on the neurovascular unit after experimental TBI in mice. FTY720 administration reduced endothelial cell apoptosis, improved BBB permeability, attenuated astrocytes and microglia activation, and increased the survival rate significantly. These findings suggest that FTY720 administration restored the structure of the NVU after experimental TBI by decreasing endothelial cell apoptosis and attenuating the activation of astrocytes, indicating a potential therapeutic strategy for TBI.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Neurosciences
Yihao Zhu, Handong Wang, Maoxing Fei, Ting Tang, Wenhao Niu, Li Zhang
Summary: Smarcd1, when expressed at low levels, promotes cell proliferation, invasion, and chemoresistance in glioblastoma cells, while enhanced expression inhibits tumor malignant phenotypes. The interaction between Smarcd1 and Notch1 forms a crucial feedback loop that regulates glioblastoma malignant phenotypes. Targeting Smarcd1 could be a potential strategy for human glioblastoma treatment.
MOLECULAR NEUROBIOLOGY
(2021)