Review
Pharmacology & Pharmacy
Shen Wang, Yifeng Yuan, Qian Lin, Hang Zhou, Binbin Tang, Yang Liu, Hai Huang, Bocheng Liang, Yingdelong Mao, Kang Liu, Xiaolin Shi
Summary: This study systematically demonstrates the antiosteoporosis effects of Tanshinol (TS) through a meta-analysis of animal models. TS increases bone mineral density, improves bone microarchitecture and bone biomechanics, and enhances the expression of bone metabolism markers.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Fan Lin, Jiaru Chen, Mangmang Chen, Shenglei Lin, Shuangxia Dong
Summary: In this study, the efficacy of resveratrol (RES) in animal models of osteoporosis (OP) was assessed through a systematic review and meta-analysis, and the potential mechanisms were summarized. The results revealed that RES significantly increased bone mineral density, bone volume, and microstructure while reducing serum phosphorus and trabecular separation in animal OP models. Moreover, RES improved bone biomechanical indexes and decreased the structural model index. Therefore, RES has great prospects as a medicine or dietary supplement for the clinical treatment of OP.
PHYTOTHERAPY RESEARCH
(2023)
Review
Geriatrics & Gerontology
Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez
Summary: Abdominal aortic calcification (AAC) is associated with lower bone mineral density (BMD) and increased fracture risk. Detecting AAC during BMD testing may provide guidance for diagnosing bone health and predicting fracture risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Metallurgy & Metallurgical Engineering
Yu Sun, Heike Helmholz, Regine Willumeit-Roemer
Summary: Degradable magnesium implants show promise for fracture treatment, but there are considerable variations in model selection and study design, highlighting the need for a standardized reference model. This systematic review aims to provide comprehensive guidance for future preclinical research on magnesium implants for fracture treatment.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Review
Materials Science, Biomaterials
Jiazhen Zhang, Zhizhong Shang, Yanbiao Jiang, Kui Zhang, Xinggang Li, Minglong Ma, Yongjun Li, Bin Ma
Summary: Biodegradable metals show mixed or contradictory outcomes in fracture repair and degradation in animal models. The quality of evidence for biodegradable metals in repairing bone fractures in animal models is currently assessed as 'very low'.
REGENERATIVE BIOMATERIALS
(2021)
Review
Plant Sciences
Bin Wu, Xiu-Fang Zhu, Xiao-Qiang Yang, Wei-Yi Wang, Jian-Hua Lu
Summary: The active compound osthole derived from Cnidium monnieri Cusson has shown to be effective in treating osteoporosis in rats, promoting bone formation and inhibiting bone absorption.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Ligia J. Dominguez, Nicola Veronese, Stefano Ciriminna, Jose Luis Perez-Albela, Vania Flora Vasquez-Lopez, Santiago Rodas-Regalado, Giovanna Di Bella, Angela Parisi, Federica Tagliaferri, Mario Barbagallo
Summary: This systematic review and meta-analysis aimed to investigate the impact of serum magnesium on the risk of fractures. Four papers with a total of 119,755 participants were included in the systematic review. The findings suggested that lower serum magnesium concentrations were associated with a significantly higher risk of incident fractures. Further research is needed to confirm these results in other populations and explore the potential role of serum magnesium in fracture prevention.
Review
Orthopedics
Daniel G. G. Wilson, Joshua Kelly, Mark Rickman
Summary: The incidence of osteoporotic pelvic fractures in elderly patients is increasing, and surgical management can significantly improve pain. However, more randomized controlled trials are needed to provide better evidence to support this intervention.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Endocrinology & Metabolism
Manju Chandran, Katherine Brind'Amour, Saeko Fujiwara, Yong-Chan Ha, Hai Tang, Jawl-Shan Hwang, James Tinker, John A. Eisman
Summary: Robust data on osteoporosis in the Asia Pacific region can improve healthcare decision-making. Osteoporosis affects 10-30% of women aged 40 + and up to 10% of men in 7 developed economies in the Asia Pacific. Fractures affect 500-1000 adults aged 50 + per 100,000 person-years. Policymakers and clinicians must address this problem.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Anesthesiology
Yuxiang Chen, Peng Yin, Yong Hai, Qingjun Su, Jincai Yang
Summary: This study aimed to evaluate the effectiveness and safety of percutaneous kyphoplasty in the treatment of osteoporotic thoracolumbar burst fracture through a systematic review. The results showed that PKP can effectively reduce pain, improve quality of life, and restore vertebral height and kyphotic angle.
Article
Biology
Markus Rupp, Christoph Biehl, Deeksha Malhan, Fathi Hassan, Sameh Attia, Sebastian Rosch, Annemarie B. Schaefer, Erin McMahon, Marian Kampschulte, Christian Heiss, Thaqif El Khassawna
Summary: Osteoporosis is a metabolic disorder characterized by lower bone density and increased risk of fracture. Fragility fractures associated with osteoporosis have a high mortality rate. Understanding fracture healing in osteoporosis is crucial for successful treatment.
Review
Endocrinology & Metabolism
Ronald Man Yeung Wong, Pui Yan Wong, Chaoran Liu, Hiu Wun Wong, Yik Lok Chung, Simon Kwoon Ho Chow, Sheung Wai Law, Wing Hoi Cheung
Summary: The incidence of imminent fracture after a prior fragility fracture is 7.58% in the first year and 11.58% in the first 2 years. Approximately half of re-fractures occur in the first 2 years after a fragility fracture. Therefore, older patients should receive prompt treatment and secondary fracture prevention after a fragility fracture to avoid the high risk of imminent fracture.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Andy Xavier, Hechmi Toumi, Eric Lespessailles
Summary: This systematic review examined animal models of glucocorticoid-induced osteoporosis (GIOP), focusing on study design, drug dose, experimental group size and allocation, and outcome measures. The review found that rats and mice were the most commonly used animal species for modeling GIOP, with male mice being preferred and genetically modified animals accounting for a significant portion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Mikkel Schou Andersen, Mikkel Seremet Kofoed, Asger Sand Paludan-Mueller, Christian Bonde Pedersen, Tiit Mathiesen, Christian Mawrin, Martin Wirenfeldt, Bjarne Winther Kristensen, Birgitte Brinkmann Olsen, Bo Halle, Frantz Rom Poulsen
Summary: This systematic review found high consistent tumor take rates (TTRs) in established cell line models and varying TTRs in primary patient-derived models and genetically engineered models. However, there were several issues identified regarding the quality of reporting and methodological approach, which reduced the validity, transparency, and reproducibility of the studies and suggested a high risk of publication bias. Finally, each tumor model type has specific roles in research based on their advantages (and disadvantages).
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Environmental Sciences
Seyed Rohallah Mousavibaygei, Amir Bisadi, Fariba ZareSakhvidi
Summary: This study systematically reviewed the evidence on the association between exposure to air pollution and osteoporosis-related outcomes. The findings suggest that PM2.5, PM10, and nitrogen dioxide may be associated with decreased bone density, osteoporotic fractures, and osteoporosis. However, due to limitations in the number of studies, heterogeneity, and publication bias, caution should be exercised in interpreting the results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Endocrinology & Metabolism
Chaoran Liu, Pui Yan Wong, Yik Lok Chung, Simon Kwoon-Ho Chow, Wing Hoi Cheung, Sheung Wai Law, Juliana Chung Ngor Chan, Ronald Man Yeung Wong
Summary: Sarcopenic obesity, the combination of age-related sarcopenia and obesity, is associated with increased risk of cardiovascular disease and metabolic disorders. Obesity reduces the risk of sarcopenia in older individuals, depending on increased muscle mass and strength.
Review
Orthopedics
Chaoran Liu, Pui Yan Wong, Simon Kwoon Ho Chow, Wing Hoi Cheung, Ronald Man Yeung Wong
Summary: This scoping review reveals the role of muscle in cognitive function. The evidence supports muscle-specific treatments as potential clinical strategies to prevent cognitive dysfunction, based on the response in the brain, muscle secretory factors, and muscle-targeted treatments caused by muscle atrophy or injury.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Endocrinology & Metabolism
X. Zhang, M. Yang, J. Zhang, P. Ye, R. M. Y. Wong, W. -H. Cheung, E. Armstrong, A. Johansen, R. Ivers, X. Wu, M. Tian
Summary: China does not yet have a national hip fracture registry, but this study is the first to recommend a core variable set for the establishment of such a registry. The inclusion of 86 core variables in the registry will improve the quality of management for older hip fracture patients in China, where the aging population experiences over half a million hip fractures each year.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Chaoran Liu, Keith Yu-Kin Cheng, Xin Tong, Wing-Hoi Cheung, Simon Kwoon-Ho Chow, Sheung Wai Law, Ronald Man Yeung Wong
Summary: This study aimed to explore the relationship between obesity and sarcopenia, and the optimal proportion of fat and muscle for old individuals. The results showed that obesity was a risk factor for sarcopenia, and there was a positive correlation between muscle mass and fat mass. It was recommended that older females should have a body fat percentage between 26.0-34.6%, while older males should have a body fat percentage below 23.9% to prevent sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Jie Li, Sharon Shui Yee Leung, Yik Lok Chung, Simon Kwoon Ho Chow, Volker Alt, Markus Rupp, Christoph Brochhausen, Chun Sing Chui, Margaret Ip, Wing-Hoi Cheung, Ronald Man Yeung Wong
Summary: This study developed a hydrogel therapy with dual release of DNase I and Vancomycin to eliminate MRSA infection and prevent biofilm formation, promoting fracture healing.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Yu-Feng Long, Simon Kwoon-Ho Chow, Can Cui, Ronald Man Yeung Wong, Ning Zhang, Ling Qin, Sheung-Wai Law, Wing-Hoi Cheung
Summary: This systematic review explores the potential relationships among physical exercise, mitochondrial function, and microRNAs in muscle. It reveals that effective physical exercise can improve mitochondrial functions by regulating microRNAs, ultimately enhancing muscle performance.
AGEING RESEARCH REVIEWS
(2023)
Article
Critical Care Medicine
Francisco Chana-Rodriguez, Taco Johan Blokhuis, Jose Maria Hernandez-Mateo, Sebastian Jazra, Sithombo Maqungo, Jean Klay Santos-Machado, Atsushi Sakurai, Ronald Man Yeung Wong, Wai-Kit Raymond, Stephanie Wagner, Robert Dunbar
Summary: Managing musculoskeletal conditions requires years of training, but there are variations in orthopaedic surgical training among countries, including the number of available positions, required examinations, gender distribution of residents, and post-training opportunities.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Immunology
Xueping Li, Huaishuang Shen, Mao Zhang, Victoria Teissier, Ejun Elijah Huang, Qi Gao, Masanori Tsubosaka, Masakazu Toya, Junichi Kushioka, Chima V. Maduka, Christopher H. Contag, Simon Kwoon-Ho Chow, Ning Zhang, Stuart B. Goodman
Summary: This study revealed the dysfunctional bioenergetic activity of bone marrow-derived macrophages (Mφ) and mesenchymal stromal cells (MSCs) exposed to contaminated polyethylene particles (cPE), which may impair the immunoregulatory properties of cells in the bone niche. The underlying molecular defect related to disordered mitochondrial function could represent a potential therapeutic target during the resolution of inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Kwan Hung Moya Tsui, Wai Wang Chau, Wing Hong Liu, Cheuk Yin Tam, Dennis King Hang Yee, Chi Yin Tso, Ning Zhang, Wing-Hoi Cheung, Ning Tang, Ronald Man Yeung Wong
Summary: Patients with concomitant COVID-19 and hip fracture have a higher risk of mortality and complications. Ct values and D-dimer levels do not have prognostic roles in hip fracture outcomes. Early operative treatment is recommended.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Cell Biology
Masakazu Toya, Ning Zhang, Masanori Tsubosaka, Junichi Kushioka, Qi Gao, Xueping Li, Simon Kwoon-Ho Chow, Stuart B. Goodman
Summary: Novel minimally invasive strategies are needed for bone healing in complex fractures and bone defects in the elderly. This study investigated the potential use of CCL2 as a therapeutic target for local cell therapy, as MSCs and macrophages play important roles in bone regeneration and inflammation. Acute stimulation with CCL2 was found to facilitate osteogenesis and macrophage migration in co-culture of MSCs and macrophages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Issei Shinohara, Masanori Tsubosaka, Masakazu Toya, Max L. Lee, Junichi Kushioka, Masatoshi Murayama, Qi Gao, Xueping Li, Ning Zhang, Simon Kwoon-Ho Chow, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman
Summary: Local cell therapy using mesenchymal stem cells (MSCs) has gained attention for treating joint diseases and fractures. This study investigated the utility of C-C motif chemokine ligand 2 (CCL2) as a therapeutic target for this therapy. The results showed that overexpression of CCL2 promoted macrophage chemotaxis and osteogenesis, as well as angiogenesis, through crosstalk between MSCs and macrophages. These findings suggest that CCL2 may be a useful target for local cell therapy in areas of bone loss.