Inflammation Intensity-Dependent Expression of Osteoinductive Wnt Proteins Is Critical for Ectopic New Bone Formation in Ankylosing Spondylitis

Molecular mechanisms of bone formation in spondyloarthritis

(2016) Susana Aideé González-Chávez et al.   JOINT BONE SPINE

Ankylosing Spondylitis and Axial Spondyloarthritis

(2016) Joel D. Taurog et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

(2016) Melissa N. van Tok et al.   PLoS One

Imbalance Between Bone Morphogenetic Protein 2 and Noggin Induces Abnormal Osteogenic Differentiation of Mesenchymal Stem Cells in Ankylosing Spondylitis

(2016) Zhongyu Xie et al.   Arthritis & Rheumatology

Treatment of a mouse model of ankylosing spondylitis with exogenous sclerostin has no effect on disease progression

(2015) Katelin R. Haynes et al.   BMC MUSCULOSKELETAL DISORDERS

Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo

(2015) Marc Clement et al.   JOURNAL OF AUTOIMMUNITY

LIM Mineralization Protein-1 Enhances Bone Morphogenetic Protein-2-Mediated Osteogenesis Through Activation of ERK1/2 MAPK Pathway and Upregulation of Runx2 Transactivity

(2015) Hehai Pan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of Enhanced Central Leptin Activity in a Scoliosis Model Created in Bipedal Amputated Mice

(2015) Tao Wu et al.   SPINE

Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppression

(2014) Tadashi Hosoya et al.   ANNALS OF THE RHEUMATIC DISEASES

Wnt signaling in ankylosing spondylitis

(2014) Maripat Corr   CLINICAL RHEUMATOLOGY

Standardized flow cytometry assay for identification of human monocytic heterogeneity and LRP1 expression in monocyte subpopulations: Decreased expression of this receptor in nonclassical monocytes

(2014) Darío G. Ferrer et al.   CYTOMETRY PART A

Pelvic retroversion is the key protective mechanism of L4–5 degenerative spondylolisthesis

(2014) Hui Liu et al.   EUROPEAN SPINE JOURNAL

Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

(2014) Bo Yu et al.   NATURE MEDICINE

Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis

(2013) Xenofon Baraliakos et al.   ANNALS OF THE RHEUMATIC DISEASES

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells

(2013) Peggy Jacques et al.   ANNALS OF THE RHEUMATIC DISEASES

Expression profiling in spondyloarthropathy synovial biopsies highlights changes in expression of inflammatory genes in conjunction with tissue remodelling genes

(2013) Gethin P Thomas et al.   BMC MUSCULOSKELETAL DISORDERS

Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis

(2013) Julie Teresa Marchesan et al.   ARTHRITIS RESEARCH & THERAPY

Inflammation and ankylosis: still an enigmatic relationship in spondyloarthritis

(2012) Rik J U Lories et al.   ANNALS OF THE RHEUMATIC DISEASES

Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis

(2012) Gisela Ruiz-Heiland et al.   ANNALS OF THE RHEUMATIC DISEASES

Continuous NSAID use reverts the effects of inflammation on radiographic progression in patients with ankylosing spondylitis

(2012) Féline Kroon et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort

(2012) Denis Poddubnyy et al.   ANNALS OF THE RHEUMATIC DISEASES

Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-α in human mesenchymal stem cells

(2012) A. Briolay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spontaneous arthritis and ankylosis in male DBA/1 mice: further evidence for a role of behavioral factors in “stress-induced arthritis”

(2012) Kirsten Braem et al.   BIOLOGICAL PROCEDURES ONLINE

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors

(2012) Katelin R Haynes et al.   ARTHRITIS RESEARCH & THERAPY

Development of new syndesmophytes and bridges in ankylosing spondylitis and their predictors: a longitudinal study

(2011) Astrid van Tubergen et al.   ANNALS OF THE RHEUMATIC DISEASES

MRI inflammation at the vertebral unit only marginally predicts new syndesmophyte formation: a multilevel analysis in patients with ankylosing spondylitis

(2011) Désirée van der Heijde et al.   ANNALS OF THE RHEUMATIC DISEASES

Focal fat lesions at vertebral corners on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis

(2011) Praveena Chiowchanwisawakit et al.   ARTHRITIS AND RHEUMATISM

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High levels of β-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway

(2011) Na Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Resolution of Inflammation Following Treatment of Ankylosing Spondylitis Is Associated with New Bone Formation

(2011) S. J. PEDERSEN et al.   JOURNAL OF RHEUMATOLOGY

Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells

(2011) Toshio Kawamoto et al.   ARTHRITIS RESEARCH & THERAPY

Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice

(2010) R. HOLMDAHL et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Activation of c-Jun NH2-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor

(2010) Hui Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pathogenesis of ankylosing spondylitis

(2010) Lai-Shan Tam et al.   Nature Reviews Rheumatology

Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis

(2009) Heiner Appel et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor α and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis

(2009) Georg Schett et al.   ARTHRITIS AND RHEUMATISM

Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis: Evidence of a relationship between inflammation and new bone formation

(2009) Walter P. Maksymowych et al.   ARTHRITIS AND RHEUMATISM

Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis

(2009) Dimitrios Daoussis et al.   ARTHRITIS AND RHEUMATISM

Osteoinductive LIM mineralization protein-1 suppresses activation of NF-κB and selectively regulates MAPK pathways in pre-osteoclasts

(2009) Hui Liu et al.   BONE

The Natural Course of Radiographic Progression in Ankylosing Spondylitis -- Evidence for Major Individual Variations in a Large Proportion of Patients

(2009) X. BARALIAKOS et al.   JOURNAL OF RHEUMATOLOGY

Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years

(2009) Désirée van der Heijde et al.   ARTHRITIS RESEARCH & THERAPY

Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis

(2008) Désirée van der Heijde et al.   ARTHRITIS AND RHEUMATISM

Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept

(2008) D. van der Heijde et al.   ARTHRITIS AND RHEUMATISM

Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

(2008) Keisuke Oguma et al.   EMBO JOURNAL

Inhibition of osteoclasts does not prevent joint ankylosis in a mouse model of spondyloarthritis

(2008) R. J. U. Lories et al.   RHEUMATOLOGY