Review
Biochemistry & Molecular Biology
Yue Liu, Liuding Wang, Guang Yang, Xiansu Chi, Xiao Liang, Yunling Zhang
Summary: Stroke is a leading cause of death and disability worldwide, with the majority of cases being ischemic stroke. The review highlights the role of sirtuins (SIRTs), a group of enzymes involved in various biological processes, in ischemic stroke. The review discusses the distribution, subcellular location, enzyme activity, and regulatory roles of SIRTs in ischemic stroke, as well as potential therapeutic methods based on SIRTs. The data collected in this study has potential implications for clinical and fundamental research on SIRTs and the development of effective therapeutic candidates for ischemic stroke treatment.
Article
Endocrinology & Metabolism
William K. Diprose, Avinash Rao, Kaustubha Ghate, Zoe Dyer, Doug Campbell, Mohammed Almekhlafi, P. Alan Barber
Summary: Therapeutic hypothermia in ischemic stroke patients may lead to lower temperatures in the ischemic penumbra, which can only be achieved through active conductive head cooling. Clinical studies are needed to validate these findings.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Xi Chen, Shuaili Xu, Ming Li, Di Wu, Xunming Ji
Summary: A recent study developed a technique of transnasal cooling that can rapidly and selectively decrease brain temperature, providing neuroprotection for acute ischemic stroke. Further improvements are necessary to enhance the benefits of selective brain cooling in the era of effective reperfusion.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Luling Wang, Longfei Wu, Yunxia Duan, Shuaili Xu, Yuyao Yang, Jidong Yin, Ye Lang, Zongen Gao, Chuanjie Wu, Zaigang Lv, Jingfei Shi, Di Wu, Xunming Ji
Summary: The mismatch between animal models and patients in terms of existing comorbidities may contribute to the failure of translational neuroprotective therapies in stroke. This study highlights the potential benefits of using multi-target neuroprotectants and stroke models with comorbidities in further translational research. The results demonstrated the neuroprotective effects of Intra-Arterial Selective Cooling Infusion (IA-SCI) in hypertensive rats may be attributed to the phenotype shifting of astrocytes.
Review
Medicine, Research & Experimental
Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, Xiangning Cui
Summary: This article reviews the glutamate-mediated excitotoxicity mechanism in post-ischemic stroke damage, focusing on the pathological changes in glutamate release, reuptake, NMDAR, and cellular signaling pathways. It also discusses new treatment targets and potential neuroprotective drugs for ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Behavioral Sciences
Elena Pala, Anna Penalba, Alejandro Bustamante, Teresa Garcia-Berrocoso, Marcel Lamana-Vallverdu, Christian Meisel, Andreas Meisel, H. Bart van der Worp, Malcolm R. Macleod, Bernd Kallmuenzer, Stefan Schwab, Joan Montaner
Summary: Blood biomarkers, including MMP-3, FABP, and IL-8, showed increased levels over time in relation to therapeutic hypothermia in stroke patients. These changes could serve as surrogate markers to evaluate the efficacy and safety of hypothermia treatment.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Alba Simats, Laura Ramiro, Raquel Valls, Helena de Ramon, Paula Garcia-Rodriguez, Cyrille Orset, Laura Artigas, Teresa Sardon, Anna Rosell, Joan Montaner
Summary: In this study, a systems biology-based approach using artificial intelligence and pattern recognition tools was employed to generate mathematical models of ischemic stroke. Through screening these models, a drug combination (CA) consisting of ceruletide and alpha-1 antitrypsin was identified to have a predicted neuroprotective value of 92%. In pre-clinical stroke models, the combination of these drugs was found to be safe and effective in reducing infarct volume and improving forepaw strength. Mechanistic studies revealed that CA modulates levels of EGFR and ANGPT-1 in circulation after stroke.
Article
Neurosciences
Bowen Weng, Chongbing Yan, Yihuan Chen, Xiaohui Gong, Cheng Cai
Summary: Therapeutic hypothermia in neonates with moderate to severe HIE was found to significantly improve neurological outcomes and reduce the incidence of death and disabilities associated with major neuron development.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Thijs R. J. Landman, Yvonne Schoon, Michiel C. Warle, Frederick J. A. Meijer, Frank-Erik De Leeuw, Dick H. J. Thijssen
Summary: This study found no significant improvement in infarct size or clinical outcome in patients with an acute ischemic stroke who were treated with repeated remote ischemic postconditioning.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Engineering, Biomedical
Wenxiu He, Zhiwen Zhang, Xianyi Sha
Summary: This review outlines the emerging approaches of nanoparticles in the effective treatment of ischemic stroke, including recanalization therapy, neuroprotection therapy, and combination therapy. It reveals the potentials and challenges of nanoparticles in treating ischemic stroke, and proposes new thoughts and perspectives for the design of feasible nanoparticles for effective treatment.
Review
Chemistry, Medicinal
Qing-zhang Tuo, Shu-ting Zhang, Peng Lei
Summary: Ischemic stroke caused by arterial occlusion is a common type of stroke that involves multiple cell death pathways such as apoptosis, necroptosis, and autophagy. Understanding these pathways may reveal new neuroprotective interventions for ischemic stroke.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Clinical Neurology
Hao Tian, Yue Wan, Haojie Zhang, Jing Zuo
Summary: This study aimed to evaluate the feasibility and effectiveness of interrupted intraarterial selective cooling infusion (IA-SCI) combined with mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS). The results showed that interrupted IA-SCI combined with MT reduced the infarct core area volumes and improved the clinical outcomes of patients compared to MT alone. Interrupted IA-SCI did not increase the risk of adverse events in terms of safety.
JOURNAL OF NEUROSURGERY
(2023)
Review
Pharmacology & Pharmacy
Jianyang Liu, Jialin He, Yan Huang, Zhiping Hu
Summary: Resveratrol treatment significantly decreased infarct volume and neurobehavioral score in ischemic stroke rodent models, particularly with a dosage of 20-50 mg/kg.Delivery route may contribute to the high heterogeneity in outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Neha, Mohd Salman, Suhel Parvez
Summary: Globally, ischemic stroke (IS) has emerged as a major cause of death and disability, with the process characterized by the formation of blood clots in the brain due to blockages in blood vessels. This triggers various signaling pathways, leading to excitotoxicity, acidosis, ionic imbalance, inflammation, oxidative stress, and ultimately cell apoptosis. The current FDA-approved tissue plasminogen activator therapy has limitations, prompting research into potential candidates like ASICs and VDCCs inhibitors for IS treatment. Animal toxins have provided neuroprotective insights into the pathophysiology of IS by inhibiting these channels.
Review
Clinical Neurology
Shao-Hua Yang, Ran Liu
Summary: The ischemic penumbra, defined four decades ago, plays a crucial role in the battleground of ischemic stroke. Therapies such as rt-PA thrombolytic therapy and mechanical thrombectomy are pivotal in treating acute ischemic stroke, with brain imaging techniques providing guidance for reperfusion therapy. The dynamic nature of the ischemic penumbra highlights the importance of timely intervention and the development of future treatment strategies for ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Sport Sciences
Zhen Wang, Bo Lv, Lin Zhang, Ran Gao, Wenbo Zhao, Lin Wang, Zhaojun Min, Zhen Mi, Yang Song, Jing Zhang, Yabin Yu, Xunming Ji, Junjie Li, Liyong Wu
Summary: The study demonstrated that a four-week RIPC intervention was effective in reducing the incidence and severity of AMS, while a one-week regimen did not show significant results. The study also suggested a potential placebo effect impacting the outcomes.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Clinical Neurology
Wenbo Zhao, Fang Jiang, Sijie Li, Guiyou Liu, Chuanjie Wu, Yuang Wang, Changhong Ren, Jing Zhang, Fei Gu, Quanzhong Zhang, Xinjing Gao, Zongen Gao, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Daily remote ischemic conditioning for seven consecutive days was safe and tolerated in patients with intracerebral hemorrhage, potentially improving hematoma resolution rate and reducing relative perihematomal edema. However, further investigations are needed to evaluate the effects on absolute hematoma and perihematomal edema volume, as well as functional outcomes in this patient population.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoxu Yang, Fang Wu, Yuehong Liu, Jiangang Duan, Marc Fisher, Xunming Ji, Ran Meng, Huibo Zhang, Zhaoyang Fan, Qi Yang
Summary: In actual clinical practice, BTI can enhance diagnostic confidence and has excellent performance in confirming and staging CVT. By using BTI imaging, the correct diagnosis rate of patients significantly improved, and CVT could be accurately staged.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Wen-Jun Tu, Feng Yan, Bao-Hua Chao, Lin Ma, Xun-Ming Ji, Long-De Wang
Summary: The study found that there was no significant difference in 1-year mortality and disability rates between patients with longer DNT times compared to those treated within 45 minutes.
NEUROLOGICAL SCIENCES
(2022)
Article
Rheumatology
Baozhen Huang, Xinning Wang, Yanlin Niu, Yuchuan Ding, Xiaolei Wang, Qingqing Tan, Yucong Li, Yuan Liu, Ying Chi, Yuan Wang, Zhixuan Zhou, Jianguo Li
Summary: This study evaluated the use of JAKi in treating JDM and found it to be a relatively safe and effective alternative. Cytokine profiles were able to reflect the inflammatory status of JDM patients.
Article
Clinical Neurology
Honglian Duan, Zhe Cheng, Ho Jun Yun, Lipeng Cai, Yanna Tong, Zhenzhen Han, Xiaokun Geng, Yuchuan Ding
Summary: This study investigates the relationship between serum bilirubin, stroke severity, and prognosis in patients with acute ischemic stroke (AIS). The results suggest that serum bilirubin levels are independently associated with stroke severity and prognosis.
NEUROLOGICAL RESEARCH
(2023)
Review
Neurosciences
Shuling Wan, Chaitu Dandu, Guangyu Han, Yibing Guo, Yuchuan Ding, Haiqing Song, Ran Meng
Summary: Cerebral small vessel disease (CSVD) is a group of pathological processes affecting small arteries, arterioles, capillaries, and small veins of the brain. Inflammation plays an important role in the pathophysiology of CSVD. MRI is the main diagnostic method for CSVD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
Fengwu Li, Xiaokun Geng, Roxanne Ilagan, Shangying Bai, Yuhua Chen, Yuchuan Ding
Summary: This study explored the effect of post-stroke exercise conditioning on brain injury and gluconeogenesis regulation. The results showed that exercise reduced brain infarct volumes, cell death, and neurological deficits after stroke. This neuroprotection was associated with the activation of the PI3K/AKT/FoxO1 signaling pathway and inhibition of gluconeogenesis.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Zhongao Wang, Chaitu Dandu, Yibing Guo, Meini Gao, Zixiang Wang, Duo Lan, Liqun Pan, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: This study aimed to explore the characteristics of high jugular bulb (JB) in patients with non-thrombotic internal jugular venous stenosis (IJVS) and/or transverse sinus stenosis (TSS) in order to investigate the pathogenesis of high JB formation. The results showed that IJVS and asymmetric transverse sinus were independently and positively associated with high JB, especially dominant-side IJVS with dominant-side high JB.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Bin Jiang, Xiaojie Wang, Jianping Ma, Aminah Fayyaz, Li Wang, Pei Qin, Yuchuan Ding, Xunming Ji, Sijie Li
Summary: Stroke is a major global health concern, and remote ischemic conditioning (RIC) has emerged as a convenient, simple, non-intrusive, and effective method for treating stroke. RIC improves brain tolerance to ischemia, increases cerebral blood perfusion, and reduces the risk of brain tissue damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Shuyu Lv, Xiaokun Geng, Ho Jun Yun, Yuchuan Ding
Summary: The study demonstrates that the combined treatment of phenothiazines can reduce autophagy levels, decrease apoptosis, and increase neuroprotection by inhibiting ER stress-mediated pathways. Phenothiazines exert their beneficial effects through the PERK-eIF2 alpha pathway, potentially paving the way for more targeted and effective treatments for stroke patients.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Hangil Lee, Enoch Kim, Martin Mccandless, Reid Johnson, Rohin Singh, Yuchuan Ding
Summary: The COVID-19 pandemic has had significant consequences for patients with cerebrovascular disorders requiring interventions. The study found an increase in cerebrovascular accidents, a decrease in elective carotid endarterectomies, and an increase in carotid stenting during the pandemic. Patients from ethnic and racial minorities were disproportionately affected, and delayed care and prolonged operative times resulted in worse outcomes.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Si-ying Song, Bao-lian Jiao, Duo Lan, Yun-huan Liu, Shu-ling Wan, Yi-bing Guo, Yu-chuan Ding, Xun-ming Ji, Ran Meng
Summary: This study aimed to evaluate the immediate effects of one-time application of remote ischemic conditioning (RIC) on inflammation and coagulation in patients with chronic cerebral vascular stenosis, and compare the different effects of RIC on cerebral arteriostenosis and cerebral venostenosis. The results showed that one-time RIC interventions may show seemingly coexisted proinflammatory and anti-coagulation effects of a single bout on patients with cerebral arteriostenosis. Older age was a negative predictor for multiple biomarkers in the cerebral arteriostensosis group. Further studies are needed to investigate the protective effect of RIC on cerebral venostenosis patients in a larger sample size.
Article
Geriatrics & Gerontology
Xiaofeng Shi, Shangming Zhu, Meijing Liu, Sara Saymuah Stone, Yao Rong, Ke Mao, Xiaopeng Xu, Chao Ma, Zhuoyuan Jiang, Yan Zha, Chun Yan, Xiaofan Yu, Di Wu, Guiyou Liu, Jidong Mi, Jianping Zhao, Yuan Li, Yuchuan Ding, Xiaogang Wang, Yong-Biao Zhang, Xunming Ji
Summary: This study demonstrates the crucial role of smooth muscle cells, particularly TNC+ SMCs, in atherosclerosis development, including enhanced extracellular matrix remodeling and transition to myofibroblasts. These findings are significant for understanding and intervening in the progression of atherosclerosis.
Review
Geriatrics & Gerontology
Sichao Guo, Ruchi Mangal, Chaitu Dandu, Xiaokun Geng, Yuchuan Ding
Summary: Stroke is a prevalent cause of death worldwide, leading to severe cellular dysfunction and long-term disability. FoxO1 plays a role in regulating cellular processes like gluconeogenesis and glycogenolysis. During stroke, FoxO1 modifications are linked to various functions such as inducing cell death and inflammation, affecting BBB, and regulating hepatic gluconeogenesis.
