Journal
BIOMATERIALS
Volume 277, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.121111
Keywords
Ischemic stroke; Nanoparticles; Recanalization therapy; Neuroprotection therapy; Combination therapy
Funding
- National Natural Science Foundation of China [81773201]
- Fudan-SIMM Joint Research Fund [FU-SIMM20182005]
- PDH-SPFDU Joint Research Fund [RHJJ201802]
- Development Project of Shanghai Peak Disciplines-Integrative Medicine [20180101]
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This review outlines the emerging approaches of nanoparticles in the effective treatment of ischemic stroke, including recanalization therapy, neuroprotection therapy, and combination therapy. It reveals the potentials and challenges of nanoparticles in treating ischemic stroke, and proposes new thoughts and perspectives for the design of feasible nanoparticles for effective treatment.
Ischemic stroke leads to high disability and mortality. The limited delivery efficiency of most therapeutic substances is a major challenge for effective treatment of ischemic stroke. Inspired by the prominent merit of nanoscale particles in brain targeting and blood-brain barrier (BBB) penetration, various functional nanoparticles have been designed as promising drug delivery platforms that are expected to improve the therapeutic effect of ischemic stroke. Based on the complex pathological mechanisms of ischemic stroke, this review outline and summarize the rationally designed nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke, including recanalization therapy, neuroprotection therapy, and combination therapy. On this bases, the potentials and challenges of nanoparticles in the treatment of ischemic stroke are revealed, and new thoughts and perspectives are proposed for the design of feasible nanoparticles for effective treatment of ischemic stroke.
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