Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs

A three-microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes

(2017) Giovanna Marziali et al.   Molecular Oncology

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response

(2017) Quintino Giorgio D’Alessandris et al.   NEURO-ONCOLOGY

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

(2016) Q Qu et al.   Cell Death & Disease

Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer

(2016) Sabina Pucci et al.   Oncotarget

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome

(2016) G. Marziali et al.   Scientific Reports

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

(2015) M. Hilvo et al.   CANCER RESEARCH

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Fatty acids on the move

(2015) Katharine H. Wrighton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

1H NMR spectroscopy of glioblastoma stem-like cells identifies alpha-aminoadipate as a marker of tumor aggressiveness

(2015) Antonella Rosi et al.   NMR IN BIOMEDICINE

Unraveling the roles of PLIN5: linking cell biology to physiology

(2015) Rachael R. Mason et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

The Evidence of Glioblastoma Heterogeneity

(2015) Akio Soeda et al.   Scientific Reports

High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism

(2014) Alessandra Cirillo et al.   CANCER BIOLOGY & THERAPY

Glioblastoma Multiforme: A Look Inside Its Heterogeneous Nature

(2014) Maria-del-Mar Inda et al.   Cancers

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

1H NMR detects different metabolic profiles in glioblastoma stem-like cells

(2013) Laura Guidoni et al.   NMR IN BIOMEDICINE

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

(2013) H. Zirath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism

(2012) Jieun Lee et al.   BMC BIOCHEMISTRY

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target

(2011) Alexander Schulte et al.   GLIA

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme

(2011) Y. Li et al.   NEURO-ONCOLOGY

MR-visible lipids and the tumor microenvironment

(2011) E. James Delikatny et al.   NMR IN BIOMEDICINE

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oligomycin-induced Bioenergetic Adaptation in Cancer Cells with Heterogeneous Bioenergetic Organization

(2010) Wenshan Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors

(2009) Tzika   INTERNATIONAL JOURNAL OF ONCOLOGY

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mesenchymal differentiation of glioblastoma stem cells

(2008) L Ricci-Vitiani et al.   CELL DEATH AND DIFFERENTIATION

Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme

(2008) R. Pallini et al.   CLINICAL CANCER RESEARCH

CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity

(2008) Adriana Y. Sierra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY