Article
Multidisciplinary Sciences
Christopher L. Yankaskas, Kaustav Bera, Konstantin Stoletov, Selma A. Serra, Julia Carrillo-Garcia, Soontorn Tuntithavornwat, Panagiotis Mistriotis, John D. Lewis, Miguel A. Valverde, Konstantinos Konstantopoulos
Summary: The study reveals a molecular mechanism by which cells avoid high shear during intravasation by activating TRPM7 channel to promote extracellular calcium influx, which then activates different pathways to coordinate the reversal of migration direction and avoid shear stress. Cells with higher TRPM7 activity levels intravasate less efficiently and establish less invasive metastatic lesions. This study provides a mechanistic interpretation for the role of shear stress and its sensor, TRPM7, in tumor cell intravasation.
Article
Materials Science, Multidisciplinary
Xuebo Wei, Zhiyong Liao, Liangliang Yang, Fangfang Wu, Shaodong Chen, Chuxiao Shao, Xin Wang, Keshen Xiao, Jian Xiao, Ke Xu, Da Sun, Hongyu Zhang
Summary: The study found that phosphorus magnesium fiber (PMF), as a novel nanoscale functional material, can accelerate wound healing. PMF releases magnesium ions into wounds, which promote wound closure and regulate macrophage polarization. This research provides insights for the potential use of PMF in wound healing and tissue regeneration.
APPLIED MATERIALS TODAY
(2023)
Article
Multidisciplinary Sciences
Kirill D. Nadezhdin, Leonor Correia, Chamali Narangoda, Dhilon S. Patel, Arthur Neuberger, Thomas Gudermann, Maria G. Kurnikova, Vladimir Chubanov, Alexander I. Sobolevsky
Summary: The transient receptor potential channel TRPM7 is a crucial regulator of divalent cation balance in the body, impacting various biological processes such as embryonic development, immune responses, and cell functionalities. It is linked to neuronal and cardiovascular disorders as well as tumor progression, highlighting its potential as a drug target. Using cryo-EM, functional analysis, and molecular dynamics simulations, researchers have unraveled two distinct structural mechanisms behind TRPM7 activation through gain-of-function mutations and the agonist naltriben. These mechanisms exhibit different conformational dynamics and involve different domains. Additionally, the study identifies a binding site for potent and selective inhibitors that stabilize the closed state of TRPM7, paving the way for the development of drugs targeting TRPM7-related channelopathies.
NATURE COMMUNICATIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Qing Liu, Suyao Li, Yuran Qiu, Jiayu Zhang, Francisco J. Rios, Zhiguo Zou, Rhian M. Touyz
Summary: Receptor tyrosine kinases are membrane spanning receptors that play important roles in cancer development. Targeted therapies against these receptors have been widely used in cancer treatment, but they can also cause cardiovascular toxicity. This review discusses the implications of tyrosine kinase inhibitors in cardiovascular toxicities and explores the potential role of TRPM7/Mg2+ in mediating these effects.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio, Susanna Zierler
Summary: The study demonstrates the functional expression of TRPM7 in neutrophils and its impact on neutrophil recruitment during inflammation. Blocking TRPM7 channel or kinase activity affects neutrophil function, indicating a potential target to treat excessive neutrophil invasion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Francisco J. Rios, Zhi-Guo Zou, Adam P. Harvey, Katie Y. Harvey, Livia L. Camargo, Karla B. Neves, Sarah E. F. Nichol, Rheure Alves-Lopes, Alexius Cheah, Maram Zahraa, Alexey G. Ryazanov, Lillia Ryazanova, Thomas Gudermann, Vladimir Chubanov, Augusto C. Montezano, Rhian M. Touyz
Summary: TRPM7 deficiency may be an important mechanism underlying cardiovascular and renal diseases caused by hyperaldosteronism, and it is associated with hypomagnesemia.
COMMUNICATIONS BIOLOGY
(2022)
Review
Immunology
Hong-Yu Liang, Yong Chen, Xin Wei, Gang-Gang Ma, Jie Ding, Chao Lu, Ren-Peng Zhou, Wei Hu
Summary: TRPM7 is an ion channel that plays a critical role in autoimmune diseases, regulating cell migration, polarization, proliferation, and cytokine secretion. It is highlighted as a potential therapeutic target for conditions such as rheumatoid arthritis, multiple sclerosis, and diabetes.
Article
Multidisciplinary Sciences
Inga Andriule, Dalia Pangonyte, Mante Almanaityte, Vaiva Patamsyte, Milda Kupryte, Dainius Karciauskas, Kanigula Mubagwa, Regina Macianskiene
Summary: The study demonstrates the presence and co-expression of TRPM6 and TRPM7 in cardiomyocytes from all chamber walls of the human heart, with increased expression in tissues from patients with ischemic heart disease. This suggests that these channels-enzymes may play a role in the pathophysiology of the disease.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Ichwaku Rastogi, Donghwan Jeon, Jena E. E. Moseman, Anusha Muralidhar, Hemanth K. Potluri, Douglas G. G. McNeel
Summary: This review discusses the role and function of B cells in the humoral immune system, as well as their ability to act as antigen presenting cells. B cells have been shown to activate antigen-specific T cells and have regulatory and cytotoxic effects. The importance of B cells within the tumor microenvironment is increasingly recognized, and B cells are being evaluated as cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Herui Wang, Bin Li, Kulsum Asha, Ryan L. Pangilinan, Asha Thuraisamy, Harman Chopra, Susumu Rokudai, Yong Yu, Carol L. Prives, Yan Zhu
Summary: Zinc deficiency can lead to MDMX protein degradation, while restoration of zinc levels can recover MDMX levels. A new protein called TRPM7, which interacts with MDMX, was identified to regulate MDMX levels by modulating intracellular zinc ion concentration. Inhibition of TRPM7 and overexpression of MDMX can both decrease the proliferation and migration of breast cancer cells like MCF-7.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhuqing Xie, Nashat Abumaria
Summary: In this study, we constructed TRPM7 clones and investigated the effects of truncating TRPM7 at different locations on ion channel activity. Truncating the kinase domain reduced channel activity, while further truncations did not have a significant effect. Truncated clones lacking the TRP or melastatin domains had a nonfunctional channel, likely due to disrupted protein stability. Adding the TRP domain to the truncated structure increased channel activity.
Article
Cell Biology
Jonathan Lagos, Sara Sagadiev, Jheimmy Diaz, Juan Pablo Bozo, Fanny Guzman, Caroline Stefani, Silvana Zanlungo, Mridu Acharya, Maria Isabel Yuseff
Summary: TLR stimulation induces autophagy in B cells and decreases their capacity to extract and present immobilized antigens. This is achieved by triggering autophagy-dependent degradation of GEF-H1, which restricts lysosome repositioning to the immune synapse. The degradation of GEF-H1 is not observed in B cells deficient in TLR-induced autophagy.
Article
Cell Biology
Marika Runsala, Elina Kuokkanen, Eveliina Uski, Vid Sustar, Meryem Ozge Balci, Johanna Rajala, Vilma Paavola, Pieta K. Mattila
Summary: In B cells, Rab7 plays an important role in antigen processing and has a higher overlap with antigen compared to Rab9. The autophagy protein LC3 colocalizes with perinuclearly clustered antigen. Inhibiting Rab7 and autophagy both affect antigen presentation.
Article
Biochemistry & Molecular Biology
Kyung-Ran Kim, Hyeon-Ju Jeong, Yoonsub Kim, Seung Yeon Lee, Yujin Kim, Hyun-Ji Kim, Suk-Ho Lee, Hana Cho, Jong-Sun Kang, Won-Kyung Ho
Summary: Calbindin plays a crucial role in shaping calcium signals in neurons, with knockout mice showing hyperexcitability and impaired pattern separation due to downregulated K+ current. The reduction of calcium buffering capacity in Tg2576 mice suggests calbindin as a target of oxidative stress. Regulation of CaMKII signaling by calcium buffering is essential for neuronal excitability regulation.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Biology
Luba Mahbub, Guennadi Kozlov, Pengyu Zong, Emma L. Lee, Sandra Tetteh, Thushara Nethramangalath, Caroline Knorn, Jianning Jiang, Ashkan Shahsavan, Lixia Yue, Loren Runnels, Kalle Gehring
Summary: ARL15 is a GTP and CNNM-binding protein that inhibits Mg2+ efflux and competes with PRLs for binding to CNNM, thereby coordinating regulation of ion transport by CNNM and TRPM7.
Article
Biochemistry & Molecular Biology
Mithunah Krishnamoorthy, Fathima Hifza Mohamed Buhari, Tiantian Zhao, Patrick M. Brauer, Kyle Burrows, Eric Yixiao Cao, Vincent Moxley-Paquette, Arthur Mortha, Juan Carlos Zuniga-Pflucker, Bebhinn Treanor
Article
Biochemistry & Molecular Biology
Mithunah Krishnamoorthy, Laabiah Wasim, Fathima Hifza Mohamed Buhari, Tiantian Zhao, Trisha Mahtani, Josephine Ho, Sohee Kang, Francina Deason-Towne, Anne-Laure Perraud, Carsten Schmitz, Bebhinn Treanor
Article
Biochemistry & Molecular Biology
Mithunah Krishnamoorthy, Fathima Hifza Mohamed Buhari, Tiantian Zhao, Patrick M. Brauer, Kyle Burrows, Eric Yixiao Cao, Vincent Moxley-Paquette, Arthur Mortha, Juan Carlos Zuniga-Pflucker, Bebhinn Treanor
Review
Cell Biology
Mithunah Krishnamoorthy, Lara Gerhardt, Saman Maleki Vareki
Summary: Myeloid cells can transform into myeloid-derived suppressor cells during cancer progression or chronic inflammation, inhibiting anti-tumor immunity. Overcoming the suppression caused by MDSCs is a major obstacle in cancer immunotherapy, highlighting the importance of understanding the mechanisms behind how MDSCs promote tumor growth for improving and developing new therapies.
Review
Oncology
Mithunah Krishnamoorthy, John G. Lenehan, Saman Maleki Vareki
Summary: Neoadjuvant immunotherapy shows promise in high-risk resectable diseases by increasing pathological response rate and prolonging relapse-free survival, with potential significance in preventing relapses. However, randomized controlled trials are needed to confirm its efficacy across different tumor types.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Review
Oncology
Mithunah Krishnamoorthy, John G. Lenehan, Jeremy P. Burton, Saman Maleki Vareki