Article
Cell Biology
Yu-Ling Sun, Tao Bai, Lin Zhou, Rong-Tao Zhu, Wei-Jie Wang, Ruo-Peng Liang, Jian Li, Chi-Xian Zhang, Jian-Jun Gou
Summary: The study reveals that deficiency of SOD3 accelerates HSC activation and EMT process, thereby promoting liver fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang You, Chongqing Gao, Junru Wu, Hengdong Qu, Yang Xiao, Ziwei Kang, Jinying Li, Jian Hong
Summary: ARK5 plays a critical role in liver fibrosis by maintaining the continuous transduction of the TGF-beta signaling pathway in HSCs and inducing epithelial-mesenchymal transition and inflammatory factor secretion in hepatocytes, thereby promoting liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ren Guo, Xiaohui Jia, Zhenbin Ding, Gang Wang, Mengmeng Jiang, Bing Li, Shanshan Chen, Bingqing Xia, Qing Zhang, Jian Liu, Ruting Zheng, Zhaobing Gao, Xin Xie
Summary: MLKL plays an important role in liver damage and fibrosis, and targeting MLKL could be an effective way to treat liver fibrosis.
Article
Biochemistry & Molecular Biology
Sam Seok Cho, Ji Hye Yang, Ji Hyun Lee, Jin Sol Baek, Sae Kwang Ku, Il Je Cho, Kyu Min Kim, Sung Hwan Ki
Summary: The study suggests that ferroptosis contributes to the progression of hepatic fibrosis by activating hepatic stellate cells and increasing the expression of fibrosis markers.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Floris Haijer, Shiva Koets-Shajari, Janette Heegsma, Sandra Serna-Salas, Tjasso Blokzijl, Manon Buist-Homan, Han Moshage, Klaas Nico Faber
Summary: Liver fibrosis is caused by excessive proliferation and collagen production by hepatic stellate cells (HSCs) due to chronic liver injury. Hydroxyurea, an anti-proliferative drug, showed inhibitory effects on HSC proliferation and fibrosis development in both in vitro and in vivo experiments. This study provides evidence for the therapeutic potential of hydroxyurea in treating liver fibrosis.
Review
Medicine, Research & Experimental
Xiaojie Hu, Qinglin Ge, Yunting Zhang, Bowen Li, Erli Cheng, Yinghong Wang, Yan Huang
Summary: Hepatic fibrosis is a common pathological process characterized by inflammation and excessive accumulation of extracellular matrix in the liver. Recent studies have shown the significant role of exosomes in the pathogenesis of hepatic fibrosis. This review systematically analyzes and summarizes the potential role of exosomes in promoting, inhibiting, and treating hepatic fibrosis, providing a clinical reference for their diagnostic and therapeutic use.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Yiming Zhu, Chihao Zhang, Mingzhe Huang, Jiayun Lin, Xiao Fan, Tao Ni
Summary: In this study, the researchers found that TRIM26 promotes HSCs ferroptosis through mediating the ubiquitination of SLC7A11, thereby suppressing liver fibrosis. The targeted suppression of SLC7A11 by TRIM26 could be a novel therapeutic strategy for liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Brandon T. Wesley, Alexander D. B. Ross, Daniele Muraro, Zhichao Miao, Sarah Saxton, Rute A. Tomaz, Carola M. Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. Mahbubani, Stephanie Brown, Jose Garcia-Bernardo, Clara Alsinet, Daniel Gaffney, Dave Horsfall, Olivia C. Tysoe, Rachel A. Botting, Emily Stephenson, Dorin-Mirel Popescu, Sonya MacParland, Gary Bader, Ian D. McGilvray, Daniel Ortmann, Fotios Sampaziotis, Kourosh Saeb-Parsy, Muzlifah Haniffa, Kelly R. Stevens, Matthias Zilbauer, Sarah A. Teichmann, Ludovic Vallier
Summary: In this study, the developmental trajectories of human fetal liver cell types were described at single-cell resolution, and bipotential hepatoblast organoids were generated. This provides a platform for investigating human liver development and producing cell types for clinical applications.
NATURE CELL BIOLOGY
(2022)
Article
Oncology
Zhiwei Liang, Jian Li, Longshuan Zhao, Yilei Deng
Summary: miR-375 is significantly downregulated in liver fibrosis, and it regulates hepatic stellate cell (HSC) activity and epithelial-mesenchymal transition (EMT) via RAC1 to exert its anti-liver fibrosis function. This study identified the miR-375/RAC1 axis as a novel regulatory mechanism in the development of liver fibrosis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Plant Sciences
Ke Chen, Weiran Guo, Rongxin Li, Yueqing Han, Qi Gao, Shuzhen Wang
Summary: This study investigates the antifibrotic properties of T-96 and its underlying molecular mechanisms. The results show that T-96 can inhibit the proliferation, migration, and activation of hepatic stellate cells and alleviate liver injury, inflammation, and fibrosis progression in a CCl4-induced liver fibrosis mouse model. Mechanistic studies reveal that the antifibrotic effect of T-96 is mediated by suppressing the expression of AGAP2 and inhibiting the phosphorylation of FAK and AKT.
Review
Gastroenterology & Hepatology
Bin Fan, He Xie, Qi Tan, Qingyuan Li, Tao Gong, Baoren He, Yujia Li, Limin Chen
Summary: Exosomes, double-membrane lipid organelles released by cells, have been shown to play various roles in intercellular information exchange, immune response, and disease progression. In the context of liver inflammation and fibrosis, macrophage-associated exosomes have emerged as important players. This review summarizes the recent advancements in studying macrophage-related exosomes in liver fibrosis and highlights the progress in using exosomes for antifibrotic therapy.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Miaomiao Wei, Xinlong Yan, Xin Xin, Haiqiang Chen, Lingling Hou, Jinhua Zhang
Summary: Hepatocyte-specific deletion of Smad4 plays an important role in promoting liver fibrosis by reducing inflammation and fibrosis, inhibiting epithelial-mesenchymal transition, hepatocyte proliferation, and migration. This study provides potential insights for future anti-fibrotic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Leke Wiering, Pallavi Subramanian, Linda Hammerich
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a wide range of severity, from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). NASH can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma, making hepatic fibrosis an important predictor of outcomes. Recent advancements in understanding the activation and inactivation of hepatic stellate cells, which drive fibrosis development, have shed light on the disease progression in NAFLD/NASH.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Yeonhwa Song, Sanghwa Kim, Jinyeong Heo, David Shum, Su-Yeon Lee, Minji Lee, A-Ram Kim, Haeng Ran Seo
Summary: This study identified retinoic acid and forskolin as potential inhibitors of fibrosis by attenuating the compactness of MCTSs and inhibiting the expression of ECM-related proteins. These drugs induced reprogramming of fibroblast and cancer stem cells in the HCC microenvironment, showing anti-fibrosis effects.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hanglu Ying, Long Li, Yufen Zhao, Feng Ni
Summary: This study evaluated the function of ivermectin in regulating liver fibrosis. The results showed that ivermectin alleviated histopathological changes, improved liver function, reduced collagen deposition, and downregulated the expression of profibrotic genes. Mechanistically, it inhibited intrahepatic macrophage accumulation and suppressed the production of proinflammatory factors. Importantly, it also promoted HSC deactivation by reducing the protein levels of alpha-smooth muscle actin (alpha-SMA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)