Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci

A Synthetic M Protein Peptide Synergizes with a CXC Chemokine Protease To Induce Vaccine-Mediated Protection against Virulent Streptococcal Pyoderma and Bacteremia

(2015) Manisha Pandey et al.   JOURNAL OF IMMUNOLOGY

The promise of reverse vaccinology

(2015) A. I. Heinson et al.   International Health

Application of the C3-Binding Motif of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Invasive Group A Streptococcal Infection

(2015) Chih-Feng Kuo et al.   PLoS One

The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design

(2014) Nina M. van Sorge et al.   Cell Host & Microbe

Group A Streptococcus Expresses a Trio of Surface Proteins Containing Protective Epitopes

(2014) Shannon E. Niedermeyer et al.   Clinical and Vaccine Immunology

The emm-Cluster Typing System for Group A Streptococcus Identifies Epidemiologic Similarities Across the Pacific Region

(2014) Noémie Baroux et al.   CLINICAL INFECTIOUS DISEASES

Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

(2014) M. J. Walker et al.   CLINICAL MICROBIOLOGY REVIEWS

Genomic Analysis of Isolates From the United Kingdom 2012 Pertussis Outbreak Reveals That Vaccine Antigen Genes Are Unusually Fast Evolving

(2014) Katie L. Sealey et al.   JOURNAL OF INFECTIOUS DISEASES

A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development

(2014) Martina Sanderson-Smith et al.   JOURNAL OF INFECTIOUS DISEASES

Development of a recombinant fusion protein vaccine formulation to protect against Streptococcus pyogenes

(2014) Garry Morefield et al.   VACCINE

Complement-mediated Opsonization of Invasive Group AStreptococcus pyogenesStrain AP53 Is Regulated by the Bacterial Two-component Cluster of Virulence Responder/Sensor (CovRS) System

(2013) Garima Agrahari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Term Antibody Memory Induced by Synthetic Peptide Vaccination Is Protective against Streptococcus pyogenes Infection and Is Independent of Memory T Cell Help

(2013) M. Pandey et al.   JOURNAL OF IMMUNOLOGY

Determining Antibody-Binding Site of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Group A Streptococcus Infection

(2013) Nina Tsao et al.   PLoS One

Group A streptococcal vaccines: Paving a path for accelerated development

(2013) James B. Dale et al.   VACCINE

Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes

(2013) Karine M. De Amicis et al.   VACCINE

Immunogenicity in mice and non-human primates of the Group A Streptococcal J8 peptide vaccine candidate conjugated to CRM197

(2013) Ivette Caro-Aguilar et al.   Human Vaccines & Immunotherapeutics

Pleiotropic virulence factor -Streptococcus pyogenesfibronectin-binding proteins

(2012) Masaya Yamaguchi et al.   CELLULAR MICROBIOLOGY

Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study

(2012) D.J. McMillan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Invasive Group A Streptococcal Disease

(2012) Andrew C. Steer et al.   DRUGS

Conserved anchorless surface proteins as group A streptococcal vaccine candidates

(2012) Anna Henningham et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Multi High-Throughput Approach for Highly Selective Identification of Vaccine Candidates: the Group A Streptococcus Case

(2012) Giuliano Bensi et al.   MOLECULAR & CELLULAR PROTEOMICS

Streptococcus pyogenes SpyCEP Influences Host-Pathogen Interactions during Infection in a Murine Air Pouch Model

(2012) Nico Chiappini et al.   PLoS One

Evaluation of novel Streptococcus pyogenes vaccine candidates incorporating multiple conserved sequences from the C-repeat region of the M-protein

(2012) Michelle J. Bauer et al.   VACCINE

New 30-valent M protein-based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci

(2011) James B. Dale et al.   VACCINE

The worldwide epidemiology of acute rheumatic fever and rheumatic heart disease

(2011) Michael D. Seckeler et al.   Clinical Epidemiology

Epidemic of Group AStreptococcusM/emm59 Causing Invasive Disease in Canada

(2010) Gregory J. Tyrrell et al.   CLINICAL INFECTIOUS DISEASES

Tissue tropisms in group A streptococcal infections

(2010) Debra E Bessen et al.   Future Microbiology

Novel Conserved Group A Streptococcal Proteins Identified by the Antigenome Technology as Vaccine Candidates for a Non-M Protein-Based Vaccine

(2010) A. Fritzer et al.   INFECTION AND IMMUNITY

The streptococcal M protein: a highly versatile molecule

(2010) Pierre R. Smeesters et al.   TRENDS IN MICROBIOLOGY

Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes

(2010) Thomas A. Penfound et al.   VACCINE

Group A streptococcal vaccines: facts versus fantasy

(2009) Andrew C Steer et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines?

(2009) Pierre R Smeesters et al.   Expert Review of Vaccines

Population biology of the human restricted pathogen, Streptococcus pyogenes

(2009) Debra E. Bessen   INFECTION GENETICS AND EVOLUTION

Emerging Role of the Interleukin‐8 Cleaving Enzyme SpyCEP in ClinicalStreptococcus pyogenesInfection

(2009) Claire E. Turner et al.   JOURNAL OF INFECTIOUS DISEASES

Model for Substrate Interactions in C5a Peptidase from Streptococcus pyogenes: A 1.9 Å Crystal Structure of the Active Form of ScpA

(2009) Todd F. Kagawa et al.   JOURNAL OF MOLECULAR BIOLOGY

Global emm type distribution of group A streptococci: systematic review and implications for vaccine development

(2009) Andrew C Steer et al.   LANCET INFECTIOUS DISEASES

Mechanism of Protection Induced by Group A Streptococcus Vaccine Candidate J8-DT: Contribution of B and T-Cells Towards Protection

(2009) Manisha Pandey et al.   PLoS One

Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi

(2009) Claire E. Turner et al.   VACCINE

The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing

(2008) Annelies S. Zinkernagel et al.   Cell Host & Microbe

Opacity Factor Activity and Epithelial Cell Binding by the Serum Opacity Factor Protein ofStreptococcus pyogenesAre Functionally Discrete

(2008) Christine M. Gillen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY