Article
Multidisciplinary Sciences
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Juecker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Mueschen, Juergen Ruland, Maike Buchner
Summary: Current therapeutic approaches in CLL focus on suppressing the PI3K/AKT signaling pathway, but research shows that CLL cells are vulnerable to hyperactivation of this pathway, which may be a promising concept for CLL therapy.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Jiasheng Chen, Wancong Zhang, Chen Pan, Jufeng Fan, Xiaoping Zhong, Shijie Tang
Summary: This study demonstrates that GLA inhibits cell proliferation and induces apoptosis in melanoma cells via the NF-kappa B/p65 pathway. It also effectively suppresses tumor growth without causing toxicity to major organs.
Article
Biochemistry & Molecular Biology
Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia, Dixian Luo
Summary: Elevated expression of AKR1B10 in breast cancer tissues was associated with lymph node metastasis, tumor size, Ki67 expression, and p53 expression, while inversely correlated with overall and disease-free survival rates. AKR1B10 promotes proliferation, migration, and invasion of breast cancer cells via the PI3K/AKT/NF-kappa B signaling pathway, indicating its potential as a prognostic indicator and therapeutic target in breast cancer.
CELL AND BIOSCIENCE
(2021)
Article
Pediatrics
Xia Zhang, Cun Liu, Yi Cao, Li Liu, Fusheng Sun, Lin Hou
Summary: This study found that RRS1 plays a role in regulating proliferation and cell cycle in neuroblastoma, and knockdown of RRS1 can inhibit cell proliferation through the PI3K/Akt/NF-kappa B pathway. Therefore, RRS1 may be a potential target for neuroblastoma treatment.
PEDIATRIC RESEARCH
(2022)
Article
Environmental Sciences
Yong Cai, Zhaoying Sheng, Jiying Wang
Summary: Xanthorrhizol, a sesquiterpenoid agent isolated from Curcuma xanthorrhiza, has shown anti-cancer properties by inducing oxidative stress, altering mitochondrial membrane potential, and modulating apoptotic signaling events in non-small cell lung carcinoma cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Hun Hwan Kim, Pritam Bhagwan Bhosale, Jeong Doo Heo, Ho Jeong Lee, Gon Sup Kim
Summary: SCU as a potential agent for HCC therapy inhibits cell proliferation and metastasis in HepG2 cells through upregulation of PTEN and inhibition of the PI3K/Akt/NF-kappa B signaling pathway. It is a natural based agent that shows promise in improving therapeutic outcomes for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Linjie He, Yinan Pan, Jiapei Yu, Ben Wang, Gaole Dai, Xiaozhou Ying
Summary: This study found that DE could inhibit inflammatory responses mediated by IL-1 beta by reducing the secretion of inflammatory factors and preventing extracellular matrix collapse. Molecular docking analysis indicated strong binding affinity of DE with PI3K inhibitory targets. In an animal model of OA, DE treatment improved articular cartilage destruction and reduced serum inflammatory factors, suggesting potential for osteoarthritis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Xizhu Wang, Liu Dong, Yifei Dong, Zhijie Bao, Songyi Lin
Summary: Hyperuricemia (HUA) is a metabolic disease characterized by elevated uric acid levels, posing a risk for premature death. Corn silk flavonoids (CSF) were found to have a protective effect against HUA by reducing inflammation and apoptosis through the down-regulating PI3K/AKT/NF-κB pathway. This study also demonstrated the UA-lowering activity of CSF in vitro and in potassium oxonate-induced HUA in vivo models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Immunology
Fang Huang, Weitong Yao, Binlian Sun, Koh Fujinaga
Summary: DCAF1 is a crucial subunit of E3 ligases and is involved in various cellular processes. It binds to the viral protein R (Vpr) of HIV-1 and plays essential roles in Vpr functions. Our study reveals that DCAF1 is necessary for NF-kappa B activation by virion-associated Vpr proteins and exogenous DCAF1 can inhibit NF-kappa B induction by external stimuli. Furthermore, we find that DCAF1 inhibits the nuclear transportation of p65 through interactions with p65, thus suppressing the NF-kappa B pathway. Additionally, two specific motifs of DCAF1 are identified to enhance its inhibitory effects on the NF-kappa B pathway.
IMMUNOLOGY LETTERS
(2022)
Article
Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Dan Li, Ying-ying Guo, Xian-feng Cen, Hong-liang Qiu, Si Chen, Xiao-feng Zeng, Qian Zeng, Man Xu, Qi-zhu Tang
Summary: The study shows that lupeol protects against cardiac hypertrophy via anti-inflammatory mechanisms by inhibiting the TLR4-PI3K-Akt-NF-kappa B signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Oncology
Fan Xu, Jiali Wang, Shuman Zhen, Yuqing Duan, Qingshan Li, Lihua Liu
Summary: The stemness characteristic of breast cancer is important for cancer recurrence and metastasis. This study found that C1ql4 is highly expressed in breast cancer tissues and cell lines, and its high expression is significantly correlated with malignancy. Mechanistically, C1ql4 promotes breast cancer cell stemness and EMT through the PI3K/AKT/NF-kB signaling pathway. Therefore, C1ql4 might be a potential target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Joseph W. Hawkins, Madeleine C. McNeill, Reza Ebrahimighaei, Harry H. Mellor, Andrew C. Newby, Mark Bond
Summary: cAMP inhibits NF-kB activity by increasing nuclear actin monomer levels, leading to immunosuppressive and anti-inflammatory effects.
Article
Chemistry, Medicinal
Yan-Qiu Zhou, Yue Sun, Han-Lin Luo, Zhong-Fei Gao, Hong-Qin Zhang, Qing-Guo Meng, Xian-Yong Bai, Gui-Ge Hou, Yun Hou
Summary: A series of novel compounds were synthesized in this study, among which the 4-CF3-substituted 4k exhibited anti-hepatoma activity and promoted apoptosis of hepatoma cells through various mechanisms. The research findings provide important scientific basis for further studies on hepatoma treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Food Science & Technology
Paz Otero, M. Carpena, P. Garcia-Oliveira, J. Echave, A. Soria-Lopez, P. Garcia-Perez, M. Fraga-Corral, Hui Cao, Shaoping Nie, Jianbo Xiao, J. Simal-Gandara, M. A. Prieto
Summary: Consumers nowadays are increasingly aware of the relationship between diet and health, leading to a preference for natural products. Seaweeds have emerged as a potential source of bioactive carbohydrates, with numerous polysaccharides arousing the interest of the scientific community due to their biological activities. Environmentally friendly extraction technologies and chemical modification methods have been developed to improve the yield, quality, and applications of seaweed polysaccharides. This review aims to compile current information about seaweed polysaccharides, including extraction and modification methods, biological activities, and future trends for their industrial applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Song Li, Jielun Hu, Haoyingye Yao, Fang Geng, Shaoping Nie
Summary: This review explores the effects of different galactans on gut microbiota and the production of short-chain fatty acids. It summarizes the structural characteristics of four types of galactans and discusses the ability of gut microbiota to utilize them. The findings suggest potential applications of galactans as functional foods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Xiumei Zhu, Jinyin Chen, Hui Wang, Zongcai Tu, Junyi Yin, Shaoping Nie
Summary: This study investigated the effects of ascorbic acid treatment on the viscosity and structural properties of okra pectic polysaccharide, and found that it was related to the formation of hydroxyl radicals. The findings provide recommendations for the application of okra pectic polysaccharide in food and other products containing ascorbic acid.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Mingzhi Li, Jiajia Wen, Xiaojun Huang, Qixing Nie, Xincheng Wu, Wanning Ma, Shaoping Nie, Mingyong Xie
Summary: This review summarizes the primary structural features of polysaccharides related to TLR4, including molecular weight, monosaccharide composition, glycosidic bonds, functional groups, and branched-chain structure. The optimal structure for interacting with TLR4 is determined through statistical analysis. In addition, the review explores the dual-directional regulation of TLR4 signaling cascade by polysaccharides from an immune balance perspective.
Article
Chemistry, Applied
Ke Zhang, Duoduo Zhang, Junqiao Wang, Yuting Wang, Jiarui Hu, Yujia Zhou, Xingtao Zhou, Shaoping Nie, Mingyong Xie
Summary: The research found that Aloe gel glucomannan (AGP) can induce cytotoxic mitophagy through ROS-related PINK1/Parkin pathway and TFEB activation. This provides a theoretical basis for the development of AGP as a promising anticancer agent.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Xincheng Wu, Xiaojun Huang, Wanning Ma, Mingzhi Li, Jiajia Wen, Chunhua Chen, Liandi Liu, Shaoping Nie
Summary: This study compared the intestinal immunomodulatory mechanisms of nine representative bioactive polysaccharides. The results revealed that these polysaccharides promote intestinal immunity through different ways, such as alleviating immune suppression in intestinal mucosal T cells, improving the intestinal microenvironment, promoting the colonization of beneficial bacteria, inhibiting the colonization of harmful bacteria, and alleviating the accumulation of certain metabolites in the large intestine. These findings provide a guideline for the development of superior intestinal immunomodulatory polysaccharides.
Article
Biochemistry & Molecular Biology
Shuping Chen, Junqiao Wang, Nan Dong, Qiuyue Fang, Yanli Zhang, Chunhua Chen, Steve W. W. Cui, Shaoping Nie
Summary: Polysaccharides from Cordyceps sinensis showed promising effects on experimental acute ulcerative colitis in mice. They alleviated colitis symptoms, inhibited NF-kappa B pathway activation, and modulated the gut microbiota composition. These findings suggest that Cordyceps sinensis polysaccharides have potential as a treatment for ulcerative colitis.
Article
Agriculture, Multidisciplinary
Tongwen Huang, Ke Zhang, Junqiao Wang, Kaihong He, Xingtao Zhou, Shaoping Nie
Summary: This study found that quercetin can alleviate the hepatotoxicity caused by acrylamide generated in heat-treated foods. Experiments on mice showed that quercetin can reduce the oxidative stress levels induced by acrylamide and protect the liver from damage. The results demonstrated that quercetin suppressed acrylamide-induced ferroptosis by inhibiting oxidative stress-driven autophagy, leading to the mitigation of liver injury.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Jinjin Liu, Junyi Yin, Xiaojun Huang, Cencen Liu, Liuyun Hu, Yansheng Huang, Fang Geng, Shaoping Nie
Summary: This study aimed to remove the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) using baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT). Results showed that AT had the best removal effect on total anthraquinones and increased the content of neutral sugars in CWEs. However, AT decreased the antioxidant activity of CWEs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Hao Zhang, Chunhua Chen, Yanli Zhang, Hongmei Yin, Jielun Hu, Yadong Zhong, Shaoping Nie, Mingyong Xie
Summary: This study comprehensively investigated and compared the fermentation characteristics of indigestible glucans (IGs) with different structural properties and their effects on the gut microbiota. The results showed that different IGs were utilized by the gut microbiota at varying rates, and some remained unfermented after 48 hours. During fermentation, IGs released mono-, di-, or trisaccharides and lowered the pH of the broth, while producing short-chain fatty acids. The analysis also revealed that different IGs selectively promoted the proliferation of specific bacteria in the gut.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Yu Wu, Wengan Zhou, RuTing Feng, Duoduo Zhang, Yongkang Yu, Zuanyuan Huang, Junyi Yin, Xingtao Zhou, Shaoping Nie
Summary: The immunomodulatory effects of glucan from fruit body of Dictyophora rubrovolvata (DRP) were evaluated in this study. It was found that DRP can recover CTX-induced immunosuppression and activate dendritic cells (DCs) to increase cytokine secretion. The study also revealed that DRP regulates the AKT-STAT1 signaling pathway via Mincle in DCs to induce CD4(+) T cell proliferation and differentiation, thereby ameliorating CTX-induced immunosuppression.
Article
Food Science & Technology
Shanshan Zhang, Yonggan Sun, Qixing Nie, Jielun Hu, Wenwen Su, Zheyu Guo, Yanli Zhang, Shaoping Nie
Summary: Polysaccharides are commonly used as carriers for colon-targeted drugs, but their degradation and effects on gut microbiota in colitis conditions are unclear. In this study, the fermentation of four polysaccharides using colonic content microbiota from mice with colitis was performed. The results show that pectin and guar gum have a greater degree of degradation and promote the production of beneficial bacteria, while carrageenan and xanthan gum promote the proliferation of harmful bacteria.
Article
Chemistry, Multidisciplinary
Anqi Xie, Haihua Ji, Zheyi Liu, Yiqun Wan, Xuecong Zhang, Huihuang Xiong, Shao-Ping Nie, Hao Wan
Summary: Oral administration of probiotics is a promising method to alleviate inflammatory bowel diseases (IBDs), but sensitivity to the gastrointestinal environment and poor intestinal colonization hinder their effectiveness. In this study, a modified prebiotic-based shield (Fe-TA@mGN) was developed to enhance the stress resistance ability and intestinal colonization of Escherichia coli Nissle 1917 (EcN). The shield improved the survival rate of EcN and its retention in the intestine, leading to efficient alleviation of colitis. Additionally, the shield synergized with EcN to regulate gut microbiota and promote the production of short-chain fatty acids, further enhancing the alleviation of colitis.
Article
Biochemistry & Molecular Biology
Qianhuang Xiao, Wenqi Huang, Quanyong Wu, Hedi Xu, Yanli Zhang, Jingrui Yang, Shuigen Bian, Huizi Tan, Shaoping Nie
Summary: A sedentary lifestyle, unhealthy diet, and antibiotic use have been associated with an increased incidence of metabolic disorders and inflammation. This study focused on the effects of pectin, an edible polysaccharide, with different esterification degrees on mice treated with a high-fat diet and low-dose antibiotics. The results showed that different types of pectin had differential effects on metabolic health, inflammatory markers, gut microbiota, and serum metabolome.
Article
Agriculture, Multidisciplinary
Shi-Kang Chen, Yu-Hao Li, Xin Wang, Yu-Qing Guo, Xiao-Xiao Song, Shao-Ping Nie, Jun-Yi Yin
Summary: In this study, the structural order of Hericium erinaceus polysaccharides from different regions was evaluated using several analysis methods, revealing various structural types including fucogalactoglucan, glucofucogalactan, fucoglucan, and glucan. The main chains of heterogalactans consist of alpha-(1 -> 6)-Galp residues, which may be substituted by Fucp and Galp residues at O-2.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
