Review
Surgery
Chai Hong Rim, Won Kyung Cho, Sunmin Park, Won Sup Yoon, Dae Sik Yang
Summary: This meta-analysis confirms the oncologic role of local ablative treatment (LAT) in treating oligometastatic nonsmall cell lung cancer, with synchronous and oligopersistent disease showing more benefit than oligoprogression/recurrence disease.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Oncology
Tianyu Lei, Jing Li, Hao Zhong, Huibo Zhang, Yan Jin, Jie Wu, Lan Li, Bin Xu, Qibin Song, Qinyong Hu
Summary: The meta-analysis on PORT in III-N2 stage NSCLC patients showed no survival benefit but significant effects on DFS and LRFS, indicating a cautious approach in treatment selection.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Shou-Feng Wang, Nai-Quan Mao, Wen-Hua Zhao, Xin-Bin Pan
Summary: This study evaluated the effect of postoperative radiotherapy on patients with non-small cell lung cancer. The results showed that radiotherapy decreased the incidence of local recurrence, but did not improve disease-free survival and overall survival.
Review
Oncology
Amir H. Safavi, David Y. Mak, R. Gabriel Boldt, Hanbo Chen, Alexander Louie
Summary: Stereotactic ablative radiotherapy (SABR) shows promising results in providing effective local control with limited toxicity for inoperable early-stage, node-negative small cell lung cancer (SCLC) patients, although further prospective studies are needed for evaluation.
Review
Oncology
Nicola Martucci, Alessandro Morabito, Antonello La Rocca, Giuseppe De Luca, Rossella De Cecio, Gerardo Botti, Giuseppe Totaro, Paolo Muto, Carmine Picone, Giovanna Esposito, Nicola Normanno, Carmine La Manna
Summary: Small-cell lung cancer (SCLC) is an aggressive tumor with limited response to chemotherapy and radiotherapy, but surgery may benefit selected early-stage patients. International guidelines recommend surgical intervention in selected stage I SCLC patients after proper evaluation.
Article
Medicine, General & Internal
Mariano Provencio, Ernest Nadal, Jose L. Gonzalez-Larriba, Alex Martinez-Marti, Reyes Bernabe, Joaquim Bosch-Barrera, Joaquin Casal-Rubio, Virginia Calvo, Amelia Insa, Santiago Ponce, Noemi Reguart, Javier de Castro, Joaquin Mosquera, Manuel Cobo, Andres Aguilar, Guillermo Lopez Vivanco, Carlos Camps, Rafael Lopez-Castro, Teresa Moran, Isidoro Barneto, Delvys Rodriguez-Abreu, Roberto Serna-Blasco, Raquel Benitez, Carlos Aguado de la Rosa, Ramon Palmero, Florentino Hernando-Trancho, Javier Martin-Lopez, Alberto Cruz-Bermudez, Bartomeu Massuti, Atocha Romero
Summary: This study evaluated the efficacy of the neoadjuvant nivolumab plus chemotherapy regimen on operable stage III non-small-cell lung cancer (NSCLC) patients. The results showed that patients receiving the combination therapy had a higher rate of pathological complete response and longer survival, indicating the effectiveness of this treatment approach in this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Huei-Tyng Huang, Michael G. Nix, Douglas H. Brand, David Cobben, Crispin T. Hiley, John D. Fenwick, Maria A. Hawkins
Summary: The study investigates the effects of different treatment schedules on tumor repopulation and alpha/beta ratio in radiotherapy and chemo-radiotherapy for locally advanced non-small cell lung cancer. The findings suggest that shorter duration of concurrent chemo-radiotherapy and moderate hypofractionation within normal tissue toxicity limits could improve the efficacy of the treatment.
Review
Surgery
Han-Yu Deng, Xiao-Ming Qiu, Da-Xing Zhu, Xiaojun Tang, Qinghua Zhou
Summary: Video-assisted thoracoscopic surgery (VATS) sleeve lobectomy shows advantages in reducing surgical trauma and improving postoperative recovery in treating centrally located non-small cell lung cancer, without compromising oncological prognosis. Despite potentially longer operation time, it can be recommended as an alternative to thoracotomy sleeve lobectomy in carefully selected cases.
WORLD JOURNAL OF SURGERY
(2021)
Review
Medicine, General & Internal
Ye Zhao, Haiming Feng, Jinhui Tian, Bin Li, Cheng Wang, Long Ge, Jian kai Wang, Kehu Yang, Qin Yu
Summary: This systematic review aims to evaluate the clinical efficacy of different combinations of CCRTs and consolidation therapies. Traditional meta-analysis and network meta-analysis methods will be used to analyze the data. The primary endpoints include overall survival and progression-free survival, while secondary outcomes include tumor response and health-related quality of life. The results of this study will be published in a peer-reviewed journal.
Article
Oncology
Gustavo A. Viani, Andre G. Gouveia, Fernando K. Matsuura, Alexandre A. Jacinto, Fabio Y. Moraes
Summary: For LS-SCLC, OD conventional chemoradiation yields similar outcomes as BID, while hypofractionated radiotherapy shows better OS and PFS. Additional phase III trials are needed to further explore hypofractionation combined with systemic therapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Respiratory System
Francis-Edouard Gravier, Pauline Smondack, Guillaume Prieur, Clement Medrinal, Yann Combret, Jean-Francois Muir, Jean-Marc Baste, Antoine Cuvelier, Fairuz Boujibar, Tristan Bonnevie
Summary: This study assessed the effects of preoperative exercise training compared to usual care on patients scheduled for lung resection. The results showed that preoperative exercise training significantly reduced postoperative complications and improved exercise capacity, pulmonary function, quality of life, and depression.
Article
Oncology
Jiupeng Zhou, Hui Guo, Yongfeng Zhang, Heng Liu, Quanli Dou
Summary: The current radiotherapy regimens for limited-stage small cell lung cancer (LS-SCLC) have similar efficacy and toxicity, except for certain conventionally fractionated radiotherapy regimens (ConvTRT1(<60 Gy)). Hypofractionated radiotherapy (HypoTRT) and hyperfractionated radiotherapy (HyperTRT) are acceptable alternatives given their comparable effectiveness and lower costs compared to ConvTRT1(<60 Gy).
Article
Respiratory System
Lianfang Ni, Gang Lin, Zhigang Zhang, Dan Sun, Zhonghui Liu, Xinmin Liu
Summary: In octogenarians with stage Ia NSCLC, surgery with lymph node dissection offers better overall survival (OS) and cancer-specific survival (CSS) outcomes than radiotherapy. The surgery group had higher survival rates compared to the radiotherapy group, with radiotherapy patients having more unfavorable factors.
BMC PULMONARY MEDICINE
(2022)
Article
Oncology
Francesco Fiorica, Umberto Tebano, Milena Gabbani, Mariasole Perrone, Sonia Missiroli, Massimiliano Berretta, Jacopo Giuliani, Andrea Bonetti, Andrea Remo, Eva Pigozzi, Andrea Tontini, Giuseppe Napoli, Nicoletta Luca, Daniela Grigolato, Paolo Pinton, Carlotta Giorgi
Summary: The combination of immune checkpoint inhibitors (ICI) plus radiotherapy (RT) in advanced or metastatic non-small cell lung cancer (NSCLC) patients significantly increases 1- and 3-year overall survival and progression-free survival, compared to ICI or RT alone, according to the study findings.
Review
Respiratory System
Chenxi Zhang, Nan Ma, Qitong Zhang, Kaifu Zheng, Chuang Sun, Xiyang Tang, Xiaofei Li, Jinbo Zhao
Summary: Local aggressive thoracic therapy can prolong overall and progression-free survival in patients with oligometastatic non-small cell lung cancer. Consolidative local therapy may be a more favorable choice. The benefits of local therapy for N2-3 positive patients should be further explored.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Oncology
Jin Wang, Li Li, Bai-qiang Dong, Yu-jin Xu, Yuan-da Zheng, Zhong-wen Sun, Yang Yang, Yuan-yuan Chen, Xiao-zhong Chen, Ming Chen
Article
Multidisciplinary Sciences
Yang Yang, Xu Wang, Qinghua Yao, Liqiang Qin, Chao Xu
SCIENTIFIC REPORTS
(2016)
Review
Gastroenterology & Hepatology
J. Luo, Y. Yang, J. Liu, K. Lu, Z. Tang, P. Liu, L. Liu, Y. Zhu
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2014)
Article
Gastroenterology & Hepatology
Yang Yang, Dan Zhang, Na Feng, Guochong Chen, Jianjiang Liu, Guiping Chen, Yuan Zhu
Letter
Oncology
Yang Yang, Yang Jiao
INTERNATIONAL JOURNAL OF CANCER
(2013)
Article
Oncology
Yang Yang, Jialin Luo, Xiaoming Zhai, Zhiqin Fu, Zhongzhu Tang, Luying Liu, Ming Chen, Yuan Zhu
INTERNATIONAL JOURNAL OF CANCER
(2014)
Article
Oncology
Yang Yang, Dan Su, Lin Zhao, Dan Zhang, Jiaying Xu, Jianmei Wan, Saijun Fan, Ming Chen
Article
Oncology
Yang Yang, Xia Zhou, Luoyong Tang, Xiaoling Xu, Xianghui Du, Guoqin Qiu
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2019)
Article
Oncology
Yang Yang, Xiaofang Xu, Xia Zhou, Wuan Bao, Danhong Zhang, Feiying Gu, Xianghui Du, Qixun Chen, Guoqin Qiu
FRONTIERS IN ONCOLOGY
(2020)
Article
Medicine, Research & Experimental
Yang Yang, Yu Chong, Mengyuan Chen, Wumin Dai, Xia Zhou, Yongling Ji, Guoqin Qiu, Xianghui Du
Summary: The study found that LDHA is overexpressed in NSCLC tissues and high LDHA expression is associated with poor prognosis and radioresistance in NSCLC patients. Inhibition of LDHA by oxamate increased radiosensitivity in NSCLC cell lines, induced apoptosis and autophagy, and altered cell cycle distribution. LDHA inhibition also led to ROS accumulation and ATP depletion, which may contribute to increased DNA damage and hinder DNA repair activity. The findings suggest that targeting LDHA may be a potential strategy to enhance radiotherapy efficacy in NSCLC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jianjiang Liu, Dongping Wu, Bin Shen, Mengyuan Chen, Xia Zhou, Peng Zhang, Guoqin Qiu, Yongling Ji, Xianghui Du, Yang Yang
Summary: This study assessed the prognostic role of lactate dehydrogenase (LDH) in limited-stage small cell lung cancer (LS-SCLC) patients treated with thoracic radiotherapy (TRT) and prophylactic cranial irradiation (PCI). The results showed that the LDH level during treatment could predict brain metastasis and survival in LS-SCLC patients, providing valuable information for treatment intensification.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Yang Yang, Tingting Feng, Xiaojun Fan, Changchun Wang, Youhua Jiang, Xia Zhou, Wu 'an Bao, Danhong Zhang, Shi Wang, Jiangping Yu, Yali Tao, Ge Song, Hua Bao, Junrong Yan, Xue Wu, Yang Shao, Guoqin Qiu, Dan Su, Qixun Chen
Summary: This study investigated the genomic factors and the effect of neoadjuvant chemoradiotherapy (nCRT) on the genome and transcriptome of patients with esophageal squamous cell carcinoma (ESCC). The codeficiency of DNA damage repair and HIPPO pathways sensitized ESCC to nCRT. nCRT induced small INDELs and focal chromosomal loss. Higher acquired INDEL% was associated with better survival, and clonal expansion degree was negatively associated with patient survival.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Jianjiang Liu, Dongping Wu, Bin Shen, Mengyuan Chen, Xia Zhou, Peng Zhang, Guoqin Qiu, Yongling Ji, Xianghui Du, Yang Yang
Summary: The study developed a scoring model to predict the cumulative risk of developing brain metastases in non-surgical treatment of limited-stage small cell lung cancer patients. It analyzed several clinical and laboratory factors associated with brain metastases and constructed a risk prediction nomogram, which provides personalized risk estimates and facilitates the decision to perform prophylactic cranial irradiation.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Medicine, Research & Experimental
Guangyuan Lou, Xianghui Du, Xia Zhou, Yonglin Ji, Wuan Bao, Yang Yang, Danhong Zhang, Lei Cheng, Ying Chen, Guoqin Qiu
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)