Titin-based mechanosensing modulates muscle hypertrophy

Functional assessment of the diaphragm by speckle tracking ultrasound during inspiratory loading

(2017) Eline Oppersma et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction

(2017) Rebecca E. Slater et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Compensatory effects following unilateral diaphragm paralysis

(2017) Obaid U. Khurram et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Ethical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017

(2017) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms

(2016) Anabelle S. Cornachione et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

(2016) Tiankun Zhou et al.   FEBS LETTERS

Changes in sarcomere lengths of the human vastus lateralis muscle with knee flexion measured using in vivo microendoscopy

(2016) Xuefeng Chen et al.   JOURNAL OF BIOMECHANICS

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

(2016) Florian Hinze et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

(2016) Stephan Lange et al.   Nature Communications

Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm20ΔRRM Mice

(2016) Hannah C. Pulcastro et al.   Frontiers in Physiology

Dynamic Myofibrillar Remodeling in Live Cardiomyocytes under Static Stretch

(2016) Huaxiao Yang et al.   Scientific Reports

Titin stiffness modifies the force-generating region of muscle sarcomeres

(2016) Yong Li et al.   Scientific Reports

Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy

(2015) Lin Zhong et al.   CARDIOVASCULAR RESEARCH

Muscle LIM Protein: Master regulator of cardiac and skeletal muscle functions

(2015) Elizabeth Vafiadaki et al.   GENE

Probing Muscle Ankyrin-Repeat Protein (MARP) Structure and Function

(2014) Alexander Shiang Lun et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole

(2014) Mei Methawasin et al.   CIRCULATION

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

(2014) Henrike Maatz et al.   JOURNAL OF CLINICAL INVESTIGATION

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

(2014) Henk L. Granzier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line

(2014) J. Bogomolovas et al.   Open Biology

Acute Skeletal Muscle Wasting in Critical Illness

(2013) Zudin A. Puthucheary et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

(2012) Guillaume Renaud et al.   JOURNAL OF PHYSIOLOGY-LONDON

Stretching Skeletal Muscle: Chronic Muscle Lengthening through Sarcomerogenesis

(2012) Alexander M. Zöllner et al.   PLoS One

Conformation-regulated mechanosensory control via titin domains in cardiac muscle

(2011) Tobias Voelkel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

(2010) Koichi Ojima et al.   JOURNAL OF CLINICAL INVESTIGATION

Truncation of Titin’s Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction

(2009) Henk L. Granzier et al.   CIRCULATION RESEARCH

The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle

(2009) Heather M. Argadine et al.   JOURNAL OF APPLIED PHYSIOLOGY

Multiple Molecular Interactions Implicate the Connectin/Titin N2A Region as a Modulating Scaffold for p94/Calpain 3 Activity in Skeletal Muscle

(2008) Chikako Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

(2008) Farah Sheikh et al.   JOURNAL OF CLINICAL INVESTIGATION

Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans

(2008) Michael E. Llewellyn et al.   NATURE