Challenges and Promises for Planning Future Clinical Research Into Bacteriophage Therapy Against Pseudomonas aeruginosa in Cystic Fibrosis. An Argumentative Review

The potential of phage therapy in cystic fibrosis: Essential human-bacterial-phage interactions and delivery considerations for use in Pseudomonas aeruginosa -infected airways

(2017) Stephanie Trend et al.   Journal of Cystic Fibrosis

Consider drug efficacy before first-in-human trials

(2017) Jonathan Kimmelman et al.   NATURE

Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler

(2017) Nicholas B. Carrigy et al.   PHARMACEUTICAL RESEARCH

Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa

(2017) Elaine M Waters et al.   THORAX

How to Name and Classify Your Phage: An Informal Guide

(2017) Evelien Adriaenssens et al.   Viruses-Basel

Phage Inhibit Pathogen Dissemination by Targeting Bacterial Migrants in a Chronic Infection Model

(2017) Sophie E. Darch et al.   mBio

A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

(2017) Silvia Moretti et al.   Nature Communications

Bacteriophages and Their Immunological Applications against Infectious Threats

(2017) Elena Criscuolo et al.   Journal of Immunology Research

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

(2017) Waqas Nasir Chaudhry et al.   PLoS One

Analyses of Short-Term Antagonistic Evolution of Pseudomonas aeruginosa Strain PAO1 and Phage KPP22 (Myoviridae Family, PB1-Like Virus Genus)

(2016) Jumpei Uchiyama et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacteriophage-encoded depolymerases: their diversity and biotechnological applications

(2016) Diana P. Pires et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bacterial competition and quorum-sensing signalling shape the eco-evolutionary outcomes of modelin vitrophage therapy

(2016) Rachel Mumford et al.   Evolutionary Applications

Genetically Engineered Phages: a Review of Advances over the Last Decade

(2016) Diana P. Pires et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections

(2016) Craig Winstanley et al.   TRENDS IN MICROBIOLOGY

Evolutionary Rationale for Phages as Complements of Antibiotics

(2016) Clara Torres-Barceló et al.   TRENDS IN MICROBIOLOGY

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences

(2016) Gillian M. Lavelle et al.   Biomed Research International

Modular Approach to Select Bacteriophages Targeting Pseudomonas aeruginosa for Their Application to Children Suffering With Cystic Fibrosis

(2016) Victor Krylov et al.   Frontiers in Microbiology

Small Colony Variants and Single Nucleotide Variations in Pf1 Region of PB1 Phage-Resistant Pseudomonas aeruginosa

(2016) Wee S. Lim et al.   Frontiers in Microbiology

Bacteriophage Procurement for Therapeutic Purposes

(2016) Beata Weber-Dąbrowska et al.   Frontiers in Microbiology

Back to the future: bacteriophages as promising therapeutic tools

(2016) P. Domingo-Calap et al.   HLA

Pyrosequencing Unveils Cystic Fibrosis Lung Microbiome Differences Associated with a Severe Lung Function Decline

(2016) Giovanni Bacci et al.   PLoS One

Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

(2016) Benjamin K. Chan et al.   Scientific Reports

A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections

(2016) Katarzyna Danis-Wlodarczyk et al.   Scientific Reports

Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine Lung

(2015) Rishi Pabary et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro and in vivo antibacterial activity of environmental bacteriophages against Pseudomonas aeruginosa strains from cystic fibrosis patients

(2015) Tomasz Olszak et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Assessing phage therapy against Pseudomonas aeruginosa using a Galleria mellonella infection model

(2015) M.L. Beeton et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically DiversePseudomonas aeruginosafrom Cystic Fibrosis Patients

(2015) Jaspreet Singh Sahota et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Pre-adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution withPseudomonas aeruginosacystic fibrosis bacterial isolates

(2015) V-P. Friman et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Phage Therapy: a Step Forward in the Treatment of Pseudomonas aeruginosa Infections

(2015) Diana P. Pires et al.   JOURNAL OF VIROLOGY

Morals, microbes, and methods

(2015) Arthur Caplan   LANCET

A century of the phage: past, present and future

(2015) George P. C. Salmond et al.   NATURE REVIEWS MICROBIOLOGY

Correction: Characterization of the Newly Isolated Lytic Bacteriophages KTN6 and KT28 and Their Efficacy against Pseudomonas aeruginosa Biofilm

(2015) Katarzyna Danis-Wlodarczyk et al.   PLoS One

Bacteriophage-based therapy in cystic fibrosis-associated Pseudomonas aeruginosa infections: rationale and current status

(2015) Jean-Marc Rolain et al.   Drug Design Development and Therapy

The Formation of Biofilms byPseudomonas aeruginosa: A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms

(2015) Tsiry Rasamiravaka et al.   Biomed Research International

On-Demand Isolation of Bacteriophages Against Drug-Resistant Bacteria for Personalized Phage Therapy

(2015) Sari Mattila et al.   Frontiers in Microbiology

Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold

(2015) Kevin A. Henry et al.   Frontiers in Microbiology

A novel bacteriophage cocktail reduces and dispersesPseudomonas aeruginosabiofilms under static and flow conditions

(2015) Diana R. Alves et al.   Microbial Biotechnology

Isolation of Phages for Phage Therapy: A Comparison of Spot Tests and Efficiency of Plating Analyses for Determination of Host Range and Efficacy

(2015) Mohammadali Khan Mirzaei et al.   PLoS One

Inhibition of Biofilm Formation by T7 Bacteriophages Producing Quorum-Quenching Enzymes

(2014) Ruoting Pei et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effectiveness of bacteriophages in the sputum of cystic fibrosis patients

(2014) E. Saussereau et al.   CLINICAL MICROBIOLOGY AND INFECTION

Phage approved in food, why not as a therapeutic?

(2014) Wessam A Sarhan et al.   Expert Review of Anti-Infective Therapy

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

(2014) Lisa Saiman et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Colistin in multi-drug resistant Pseudomonas aeruginosa blood-stream infections

(2014) Nihal Martis et al.   JOURNAL OF INFECTION

In vitro design of a novel lytic bacteriophage cocktail with therapeutic potential against organisms causing diabetic foot infections

(2014) J. J. Mendes et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Phage therapy gets revitalized

(2014) Sara Reardon   NATURE

A Window of Opportunity to Control the Bacterial Pathogen Pseudomonas aeruginosa Combining Antibiotics and Phages

(2014) Clara Torres-Barceló et al.   PLoS One

Natural solution to antibiotic resistance: bacteriophages ‘The Living Drugs’

(2014) Sabah A. A. Jassim et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Effect of Bacteriophage Infection in Combination with Tobramycin on the Emergence of Resistance in Escherichia coli and Pseudomonas aeruginosa Biofilms

(2014) Lindsey Coulter et al.   Viruses-Basel

Phage–host interplay: examples from tailed phages and Gram-negative bacterial pathogens

(2014) Soraya Chaturongakul et al.   Frontiers in Microbiology

PredictingIn VivoEfficacy of Therapeutic Bacteriophages Used To Treat Pulmonary Infections

(2013) Marine Henry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications

(2013) Zuzanna Drulis-Kawa et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Back to the future: evolving bacteriophages to increase their effectiveness against the pathogenPseudomonas aeruginosaPAO1

(2013) Alex Betts et al.   Evolutionary Applications

Phage cocktails and the future of phage therapy

(2013) Benjamin K Chan et al.   Future Microbiology

Biofilm Matrix and Its Regulation in Pseudomonas aeruginosa

(2013) Qing Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Susceptibility of Pseudomonas aeruginosa Strains from Cystic Fibrosis Patients to Bacteriophages

(2013) Christiane Essoh et al.   PLoS One

Bacteriophage adhering to mucus provide a non-host-derived immunity

(2013) J. J. Barr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

(2013) Shaan L. Gellatly et al.   Pathogens and Disease

Rapid Identification of International Multidrug-Resistant Pseudomonas aeruginosa Clones by Multiple-Locus Variable Number of Tandem Repeats Analysis and Investigation of Their Susceptibility to Lytic Bacteriophages

(2012) Jérôme Larché et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of Sequential and Simultaneous Applications of Bacteriophages on Populations of Pseudomonas aeruginosaIn Vitroand in Wax Moth Larvae

(2012) Alex R. Hall et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Novel approaches to the treatment ofPseudomonas aeruginosainfections in cystic fibrosis

(2012) Matthew N. Hurley et al.   EUROPEAN RESPIRATORY JOURNAL

Evolutionary dynamics of separate and combined exposure ofPseudomonas fluorescensSBW25 to antibiotics and bacteriophage

(2012) Patricia Escobar-Páramo et al.   Evolutionary Applications

Introducing yesterday’s phage therapy in today’s medicine

(2012) Jean-Paul Pirnay et al.   Future Virology

Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010

(2012) Dawn M. Sievert et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

The CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages

(2012) K. C. Cady et al.   JOURNAL OF BACTERIOLOGY

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system

(2012) Joe Bondy-Denomy et al.   NATURE

What is needed for phage therapy to become a reality in Western medicine?

(2012) Harald Brüssow   VIROLOGY

Bacteriophages  MR299-2 and  NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells

(2012) D. Alemayehu et al.   mBio

Reversing Bacterial Resistance to Antibiotics by Phage-Mediated Delivery of Dominant Sensitive Genes

(2011) Rotem Edgar et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype

(2011) S. Pollini et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antibacterial efficacy of lytic Pseudomonas bacteriophage in normal and neutropenic mice models

(2011) Birendra R. Tiwari et al.   JOURNAL OF MICROBIOLOGY

Spray-dried Respirable Powders Containing Bacteriophages for the Treatment of Pulmonary Infections

(2011) Sadaf Matinkhoo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Recent advances in bacteriophage therapy: how delivery routes, formulation, concentration and timing influence the success of phage therapy

(2011) Elizabeth M. Ryan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pulmonary Bacteriophage Therapy on Pseudomonas aeruginosa Cystic Fibrosis Strains: First Steps Towards Treatment and Prevention

(2011) Eric Morello et al.   PLoS One

Use of newly isolated phages for control of Pseudomonas aeruginosa PAO1 and ATCC 10145 biofilms

(2011) Diana Pires et al.   RESEARCH IN MICROBIOLOGY

Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions

(2010) Julia Garbe et al.   BMC MICROBIOLOGY

Pseudomonas aeruginosa Cystic Fibrosis isolates of similar RAPD genotype exhibit diversity in biofilm forming ability in vitro

(2010) Elena Deligianni et al.   BMC MICROBIOLOGY

Pseudomonas aeruginosabiofilms in cystic fibrosis

(2010) Niels Høiby et al.   Future Microbiology

In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from the lower respiratory tract of Intensive Care Unit patients with nosocomial pneumonia and receiving antipseudomonal therapy

(2010) Mickaël Riou et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In vitro lung delivery of bacteriophages KS4-M and ΦKZ using dry powder inhalers for treatment of Burkholderia cepacia complex and Pseudomonas aeruginosa infections in cystic fibrosis

(2010) L. Golshahi et al.   JOURNAL OF APPLIED MICROBIOLOGY

Bacteriophages Can Treat and PreventPseudomonas aeruginosaLung Infections

(2010) Laurent Debarbieux et al.   JOURNAL OF INFECTIOUS DISEASES

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

Early Eradication of Pseudomonas aeruginosa in Patients with Cystic Fibrosis

(2010) Bridget Stuart et al.   Paediatric Respiratory Reviews

The Phage Therapy Paradigm: Prêt-à-Porter or Sur-mesure?

(2010) Jean-Paul Pirnay et al.   PHARMACEUTICAL RESEARCH

Bacteriophages as potential new therapeutics to replace or supplement antibiotics

(2010) Mzia Kutateladze et al.   TRENDS IN BIOTECHNOLOGY

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Future antibiotics scenarios: is the tide starting to turn?

(2009) Ursula Theuretzbacher   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Efficacy of Bacteriophage Therapy in a Model ofBurkholderia cenocepaciaPulmonary Infection

(2009) Lisa A. Carmody et al.   JOURNAL OF INFECTIOUS DISEASES

Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy

(2009) Quinn M. Parks et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Use of Phages for the Removal of Infectious Biofilms

(2008) J. Azeredo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway

(2007) Sophie Moreau-Marquis et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS