The Francisella Type VI Secretion System

Whole genome transcriptomics reveals global effects including up-regulation of Francisella pathogenicity island gene expression during active stringent response in the highly virulent Francisella tularensis subsp. tularensis SCHU S4

(2017) Amber L. Murch et al.   MICROBIOLOGY-SGM

In situ architecture, function, and evolution of a contractile injection system

(2017) Désirée Böck et al.   SCIENCE

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape

(2017) Maj Brodmann et al.   Nature Communications

Cryo-EM structure of the extended type VI secretion system sheath–tube complex

(2017) Jing Wang et al.   Nature Microbiology

Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex

(2017) Van Son Nguyen et al.   Nature Microbiology

Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth

(2016) Aria Eshraghi et al.   Cell Host & Microbe

TssA forms a gp6‐like ring attached to the type VI secretion sheath

(2016) Sara Planamente et al.   EMBO JOURNAL

Domestication of a housekeeping transglycosylase for assembly of a Type VI secretion system

(2016) Yoann G Santin et al.   EMBO REPORTS

Structure–Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes

(2016) Abdelrahim Zoued et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component

(2016) Laureen Logger et al.   JOURNAL OF MOLECULAR BIOLOGY

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Priming and polymerization of a bacterial contractile tail structure

(2016) Abdelrahim Zoued et al.   NATURE

Structure of the T4 baseplate and its function in triggering sheath contraction

(2016) Nicholas M. I. Taylor et al.   NATURE

Aim, Load, Fire: The Type VI Secretion System, a Bacterial Nanoweapon

(2016) Francesca R. Cianfanelli et al.   TRENDS IN MICROBIOLOGY

The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules

(2016) Pierre Legrand et al.   mBio

Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis

(2016) Brent S. Weber et al.   mBio

VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System

(2016) Francesca R. Cianfanelli et al.   PLoS Pathogens

Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence

(2016) Mélanie Rigard et al.   PLoS Pathogens

Trogocytosis-associated cell to cell spread of intracellular bacterial pathogens

(2016) Shaun Steele et al.   eLife

Catch me if you can

(2016) Emilie Bourdonnay et al.   eLife

The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting

(2016) Thibault G. Sana et al.   Frontiers in Cellular and Infection Microbiology

Structure of the Type VI Secretion System Contractile Sheath

(2015) Mikhail Kudryashev et al.   CELL

Atomic Structure of T6SS Reveals Interlaced Array Essential to Function

(2015) Daniel L. Clemens et al.   CELL

Biogenesis and structure of a type VI secretion membrane core complex

(2015) Eric Durand et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states

(2015) Peng Ge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Type VI secretion system: secretion by a contractile nanomachine

(2015) Marek Basler   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states

(2015) Peng Ge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization

(2015) Yannick R. Brunet et al.   PLoS Genetics

A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism

(2014) Alistair B. Russell et al.   Cell Host & Microbe

Type VI secretion and bacteriophage tail tubes share a common assembly pathway

(2014) Y. R. Brunet et al.   EMBO REPORTS

Genetically distinct pathways guide effector export through the type VI secretion system

(2014) John C. Whitney et al.   MOLECULAR MICROBIOLOGY

Type VI secretion system effectors: poisons with a purpose

(2014) Alistair B. Russell et al.   NATURE REVIEWS MICROBIOLOGY

Role of Pathogenicity Determinant Protein C (PdpC) in Determining the Virulence of the Francisella tularensis Subspecies tularensis SCHU

(2014) Akihiko Uda et al.   PLoS One

A Type VI Secretion System Is Involved in Pseudomonas fluorescens Bacterial Competition

(2014) Victorien Decoin et al.   PLoS One

Marine Tubeworm Metamorphosis Induced by Arrays of Bacterial Phage Tail-Like Structures

(2014) N. J. Shikuma et al.   SCIENCE

VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors

(2014) Eric Durand et al.   TRENDS IN MICROBIOLOGY

Lipidation of the FPI protein IglE contributes toFrancisella tularensisssp.novicidaintramacrophage replication and virulence

(2014) Jesse Q. Nguyen et al.   Pathogens and Disease

Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions

(2013) Marek Basler et al.   CELL

A View to a Kill: The Bacterial Type VI Secretion System

(2013) Brian T. Ho et al.   Cell Host & Microbe

IglE Is an Outer Membrane-Associated Lipoprotein Essential for Intracellular Survival and Murine Virulence of Type A Francisella tularensis

(2013) Gregory T. Robertson et al.   INFECTION AND IMMUNITY

Three-dimensional Structure of the Toxin-delivery Particle Antifeeding Prophage ofSerratia entomophila

(2013) J. Bernard Heymann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System

(2013) Abdelrahim Zoued et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

(2013) Julie M. Silverman et al.   MOLECULAR CELL

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

(2013) Mikhail M. Shneider et al.   NATURE

Imaging Type VI Secretion-Mediated Bacterial Killing

(2013) Yannick R. Brunet et al.   Cell Reports

Disruption of Francisella tularensis Schu S4iglI,iglJ, andpdpCGenes Results in Attenuation for Growth in Human Macrophages andIn VivoVirulence in Mice and Reveals a Unique Phenotype forpdpC

(2012) Matthew E. Long et al.   INFECTION AND IMMUNITY

Hcp2, a Secreted Protein of the Phytopathogen Pseudomonas syringae pv. Tomato DC3000, Is Required for Fitness for Competition against Bacteria and Yeasts

(2012) Minna Haapalainen et al.   JOURNAL OF BACTERIOLOGY

IcmF Family Protein TssM Exhibits ATPase Activity and Energizes Type VI Secretion

(2012) Lay-Sun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Second Type VI Secretion System ofPseudomonas aeruginosaStrain PAO1 Is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells

(2012) Thibault G. Sana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization and Oligomerization of the TssL Protein, a Component Shared by Bacterial Type VI and Type IVb Secretion Systems

(2012) Eric Durand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the Conserved Type Six Secretion Protein TssL (DotU) from Francisella novicida

(2012) Craig S. Robb et al.   JOURNAL OF MOLECULAR BIOLOGY

Visualizing a Complete Siphoviridae Member by Single-Particle Electron Microscopy: the Structure of Lactococcal Phage TP901-1

(2012) C. Bebeacua et al.   JOURNAL OF VIROLOGY

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

Unique Substrates Secreted by the Type VI Secretion System of Francisella tularensis during Intramacrophage Infection

(2012) Jeanette E. Bröms et al.   PLoS One

Type 6 Secretion Dynamics Within and Between Bacterial Cells

(2012) M. Basler et al.   SCIENCE

The structure ofSerratia marcescensLip, a membrane-bound component of the type VI secretion system

(2011) Vincenzo A. Rao et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Cluster 1 Type VI Secretion System Is a Major Virulence Determinant inBurkholderia pseudomallei

(2011) Mary N. Burtnick et al.   INFECTION AND IMMUNITY

IglG and IglI of the Francisella Pathogenicity Island Are Important Virulence Determinants of Francisella tularensis LVS

(2011) Jeanette E. Bröms et al.   INFECTION AND IMMUNITY

O-Antigen-Deficient Francisella tularensis Live Vaccine Strain Mutants Are Ingested via an Aberrant Form of Looping Phagocytosis and Show Altered Kinetics of Intracellular Trafficking in Human Macrophages

(2011) Daniel L. Clemens et al.   INFECTION AND IMMUNITY

Molecular Basis for the Unique Role of the AAA+Chaperone ClpV in Type VI Protein Secretion

(2011) Aleksandra Pietrosiuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion

(2011) O. M. de Bruin et al.   MICROBIOLOGY-SGM

Towards a Structural Comprehension of Bacterial Type VI Secretion Systems: Characterization of the TssJ-TssM Complex of an Escherichia coli Pathovar

(2011) Catarina Felisberto-Rodrigues et al.   PLoS Pathogens

The Francisella Intracellular Life Cycle: Toward Molecular Mechanisms of Intracellular Survival and Proliferation

(2011) Audrey Chong et al.   Frontiers in Microbiology

Objections to the transfer of Francisella novicida to the subspecies rank of Francisella tularensis

(2010) A. Johansson et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

The SciZ protein anchors the enteroaggregativeEscherichia coliType VI secretion system to the cell wall

(2010) Marie-Stéphanie Aschtgen et al.   MOLECULAR MICROBIOLOGY

Structure of the bacteriophage T4 long tail fiber receptor-binding tip

(2010) S. G. Bartual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions

(2010) Sandra Schwarz et al.   PLoS Pathogens

The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling

(2010) Jeanette E. Bröms et al.   Frontiers in Microbiology

Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?

(2009) Frédéric Boyer et al.   BMC GENOMICS

Intracellular biology and virulence determinants ofFrancisella tularensisrevealed by transcriptional profiling inside macrophages

(2009) Tara D. Wehrly et al.   CELLULAR MICROBIOLOGY

A Type VI Secretion System Effector Protein, VgrG1, from Aeromonas hydrophila That Induces Host Cell Toxicity by ADP Ribosylation of Actin

(2009) G. Suarez et al.   JOURNAL OF BACTERIOLOGY

An IcmF Family Protein, ImpLM, Is an Integral Inner Membrane Protein Interacting with ImpKL, and Its Walker A Motif Is Required for Type VI Secretion System-Mediated Hcp Secretion in Agrobacterium tumefaciens

(2009) L.-S. Ma et al.   JOURNAL OF BACTERIOLOGY

A Conserved  -Helix Essential for a Type VI Secretion-Like System of Francisella tularensis

(2009) J. E. Broms et al.   JOURNAL OF BACTERIOLOGY

The phage   major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system

(2009) L. G. Pell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type VI secretion: a beginner's guide

(2008) Lewis EH Bingle et al.   CURRENT OPINION IN MICROBIOLOGY

The Francisella Pathogenicity Island Protein PdpD Is Required for Full Virulence and Associates with Homologues of the Type VI Secretion System

(2008) J. S. Ludu et al.   JOURNAL OF BACTERIOLOGY

Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila

(2007) Giovanni Suarez et al.   MICROBIAL PATHOGENESIS