Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets

(2018) Ángel F. Álvarez-Prado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stellaris™ fluorescence in situ hybridization (FISH) probes: a powerful tool for mRNA detection

(2018) Arturo Orjalo et al.   NATURE METHODS

AID Biology: A pathological and clinical perspective

(2017) Meenal Choudhary et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Eye lens radiocarbon reveals centuries of longevity in the Greenland shark (Somniosus microcephalus)

(2016) J. Nielsen et al.   SCIENCE

Evolution of vertebrate adaptive immunity: Immune cells and tissues, and AID/APOBEC cytidine deaminases

(2015) Masayuki Hirano   BIOESSAYS

The development and function of thymic B cells

(2015) Jason Perera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance

(2015) Tineke Cantaert et al.   IMMUNITY

B cell Variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions

(2015) Jasmine Saini et al.   MOLECULAR IMMUNOLOGY

Overlapping hotspots in CDRs are critical sites for V region diversification

(2015) Lirong Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-evaluation of the Immunological Big Bang

(2014) Martin F. Flajnik   CURRENT BIOLOGY

Characteristics of the somatic hypermutation in the Camelus dromedarius T cell receptor gamma (TRG) and delta (TRD) variable domains

(2014) Salvatrice Ciccarese et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes

(2013) Taras Kreslavsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection

(2013) J. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin of Immunoglobulin Isotype Switching

(2012) Catherine Zhu et al.   CURRENT BIOLOGY

Generation of diversity by somatic mutation in theCamelus dromedariusT-cell receptor gamma variable domains

(2012) Giovanna Vaccarelli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recombination, transcription, and diversity of a partially germline-joined VH in a mammal

(2012) Xinxin Wang et al.   IMMUNOGENETICS

A Second TCR  Locus in Galliformes Uses Antibody-like V Domains: Insight into the Evolution of TCR  and TCR  Genes in Tetrapods

(2012) Z. E. Parra et al.   JOURNAL OF IMMUNOLOGY

Hybrid error correction and de novo assembly of single-molecule sequencing reads

(2012) Sergey Koren et al.   NATURE BIOTECHNOLOGY

Lower TCR repertoire diversity in Traj18-deficient mice

(2012) Romain Bedel et al.   NATURE IMMUNOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Thymic nurse cells provide microenvironment for secondary T cell receptor   rearrangement in cortical thymocytes

(2012) Y. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-induced cytidine deaminase structure and functions: A species comparative view

(2011) Vasco M. Barreto et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II

(2011) Michael F. Criscitiello et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Somatic hypermutation of TCR γ V genes in the sandbar shark

(2011) Hao Chen et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Platypus TCR μ Provides Insight into the Origins and Evolution of a Uniquely Mammalian TCR Locus

(2011) Xinxin Wang et al.   JOURNAL OF IMMUNOLOGY

Antibody Repertoire Development in Fetal and Neonatal Piglets. XX. B Cell Lymphogenesis Is Absent in the Ileal Peyer’s Patches, Their Repertoire Development Is Antigen Dependent, and They Are Not Required for B Cell Maintenance

(2011) John E. Butler et al.   JOURNAL OF IMMUNOLOGY

Expression and genomic analyses of Camelus dromedarius T cell receptor delta (TRD) genes reveal a variable domain repertoire enlargement due to CDR3 diversification and somatic mutation

(2011) Rachele Antonacci et al.   MOLECULAR IMMUNOLOGY

Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age

(2011) Hongyan Qin et al.   PLoS One

Evolution of the V, D, and J gene segments used in the primate    T-cell receptor reveals a dichotomy of conservation and diversity

(2011) A. R. Kazen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-induced cytidine deaminase mediates central tolerance in B cells

(2011) M. Kuraoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes

(2010) Zuly E. Parra et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B-cell development: one problem, multiple solutions

(2010) Noorjahan Banu Alitheen et al.   IMMUNOLOGY AND CELL BIOLOGY

Evolutionarily Conserved TCR Binding Sites, Identification of T Cells in Primary Lymphoid Tissues, and Surprising Trans-Rearrangements in Nurse Shark

(2010) M. F. Criscitiello et al.   JOURNAL OF IMMUNOLOGY

A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey

(2010) L. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual nature of the adaptive immune system in lampreys

(2009) Peng Guo et al.   NATURE

Characterization of arrangement and expression of the T cell receptor   locus in the sandbar shark

(2009) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Those other mammals: The immunoglobulins and T cell receptors of marsupials and monotremes

(2009) Robert D. Miller   SEMINARS IN IMMUNOLOGY

An in vitro model of T cell receptor revision in mature human CD8+ T cells

(2007) Erica Lantelme et al.   MOLECULAR IMMUNOLOGY