Mitochondria-homing peptide functionalized nanoparticles performing dual extracellular/intracellular roles to inhibit aminoglycosides induced ototoxicity

Systematic investigation on the intracellular trafficking network of polymeric nanoparticles

(2017) Jinxie Zhang et al.   Nanoscale

Aminoglycoside-Induced Cochleotoxicity: A Review

(2017) Meiyan Jiang et al.   Frontiers in Cellular Neuroscience

Towards the Prevention of Aminoglycoside-Related Hearing Loss

(2017) Mary E. O’Sullivan et al.   Frontiers in Cellular Neuroscience

Targeted delivery of geranylgeranylacetone to mitochondria by triphenylphosphonium modified nanoparticles: a promising strategy to prevent aminoglycoside-induced hearing loss

(2017) Zhenjie Wang et al.   Biomaterials Science

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

(2017) Timothy Erickson et al.   eLife

Peptide-Mediated Delivery of Chemical Probes and Therapeutics to Mitochondria

(2016) Sae Rin Jean et al.   ACCOUNTS OF CHEMICAL RESEARCH

Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells

(2016) Sarah Neveux et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells

(2016) Dale W. Hailey et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death

(2016) Robert Esterberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs

(2016) Alan D. Tate et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development

(2016) Chengfu Cai et al.   Frontiers in Cellular Neuroscience

Forcing open TRP channels: Mechanical gating as a unifying activation mechanism

(2015) Chao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel cell-penetrating peptide targeting mitochondria

(2015) Carmine Pasquale Cerrato et al.   FASEB JOURNAL

Autophagy in zebrafish

(2015) Máté Varga et al.   METHODS

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

(2015) Kiyoto Kurima et al.   Cell Reports

Reactive Oxygen Species, Apoptosis, and Mitochondrial Dysfunction in Hearing Loss

(2015) Teru Kamogashira et al.   Biomed Research International

There and back again: development and regeneration of the zebrafish lateral line system

(2014) Eric D. Thomas et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus

(2013) Qingguo Xu et al.   JOURNAL OF CONTROLLED RELEASE

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Clathrin-independent endocytosis: mechanisms and function

(2011) Kirsten Sandvig et al.   CURRENT OPINION IN CELL BIOLOGY

The early steps of endocytosis: From cargo selection to membrane deformation

(2011) Yijian Rao et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells

(2011) Ruben S. Stepanyan et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Chemical Screening for Hair Cell Loss and Protection in the Zebrafish Lateral Line

(2010) Allison B. Coffin et al.   Zebrafish

Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos

(2009) Congcong He et al.   Autophagy

Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways

(2009) Kelly N. Owens et al.   HEARING RESEARCH

Inhibition of Dynamin Mediated Endocytosis by theDynoles—Synthesis and Functional Activity of a Family of Indoles

(2009) Timothy A. Hill et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Mitochondria

(2008) Adam T. Hoye et al.   ACCOUNTS OF CHEMICAL RESEARCH