LARP1 on TOP of ribosome production

Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes

(2017) Antonio Gentilella et al.   MOLECULAR CELL

The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives

(2017) Richard J. Maraia et al.   Wiley Interdisciplinary Reviews-RNA

Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

(2017) Ana Tamarkin-Ben-Harush et al.   eLife

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

(2017) Sungki Hong et al.   eLife

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

(2017) Roni M Lahr et al.   eLife

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

(2016) Valentina Gandin et al.   GENOME RESEARCH

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation

(2016) Stefan Grüner et al.   MOLECULAR CELL

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

(2016) Yoshinori Tsukumo et al.   Nature Communications

The race to decipher the top secrets of TOP mRNAs

(2015) Oded Meyuhas et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

The molecular pathogenesis of the myelodysplastic syndromes

(2015) Andrea Pellagatti et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

(2015) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Architecture of 4E-BP Translational Inhibitors Bound to eIF4E

(2015) Daniel Peter et al.   MOLECULAR CELL

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer

(2015) Thomas G. Hopkins et al.   NUCLEIC ACIDS RESEARCH

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

(2015) Noa Liberman et al.   NUCLEIC ACIDS RESEARCH

The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence

(2015) Roni M. Lahr et al.   NUCLEIC ACIDS RESEARCH

Discovery of m7G-cap in eukaryotic mRNAs

(2015) Yasuhiro FURUICHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response

(2015) Christopher J. Kershaw et al.   PLoS Genetics

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

(2014) J. Tcherkezian et al.   GENES & DEVELOPMENT

Reassessment of the Role of TSC, mTORC1 and MicroRNAs in Amino Acids-Meditated Translational Control of TOP mRNAs

(2014) Ilona Patursky-Polischuk et al.   PLoS One

The ever-evolving role of mTOR in translation

(2014) Bruno D. Fonseca et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

(2014) Rachel Miloslavski et al.   Journal of Molecular Cell Biology

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

(2014) Cátia Igreja et al.   Nature Communications

LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA

(2013) Kazuma Aoki et al.   FEBS LETTERS

A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing

(2013) Xinfu Jiao et al.   MOLECULAR CELL

eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition

(2013) M. J. Osborne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR

(2011) C. K. Damgaard et al.   GENES & DEVELOPMENT

mRNA helicases: the tacticians of translational control

(2011) Armen Parsyan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Conserved and divergent features of the structure and function of La and La-related proteins (LARPs)

(2010) Mark A. Bayfield et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cap and cap-binding proteins in the control of gene expression

(2010) Ivan Topisirovic et al.   Wiley Interdisciplinary Reviews-RNA

Relationship of differential gene expression profiles in CD34+ myelodysplastic syndrome marrow cells to disease subtype and progression

(2009) K. Sridhar et al.   BLOOD

A comprehensive analysis of the La-motif protein superfamily

(2009) C. Bousquet-Antonelli et al.   RNA

The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner

(2008) I. Patursky-Polischuk et al.   MOLECULAR AND CELLULAR BIOLOGY

All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAs

(2008) V. Iadevaia et al.   RNA

C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis

(2008) K. Nykamp et al.   RNA