De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions
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Title
De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions
Authors
Keywords
Sterols, Fatty acids, Trypanosoma, Biosynthesis, Threonine, Leucine, Glucose, Glucose metabolism
Journal
PLoS Pathogens
Volume 14, Issue 5, Pages e1007116
Publisher
Public Library of Science (PLoS)
Online
2018-05-30
DOI
10.1371/journal.ppat.1007116
References
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Note: Only part of the references are listed.- Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei
- (2017) Mariana Leão de Lima Stein et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
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- (2015) Frédéric Bringaud et al. MOLECULAR MICROBIOLOGY
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- (2015) Darren J. Creek et al. PLoS Pathogens
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- (2014) Antonio D. Uttaro MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- The growing landscape of lysine acetylation links metabolism and cell signalling
- (2014) Chunaram Choudhary et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2014) Stefan Allmann et al. PLoS One
- Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA
- (2013) Matthew K. Gould et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop
- (2013) Rajesh K. Harijan et al. BIOCHEMICAL JOURNAL
- Cytosolic NADPH Homeostasis in Glucose-starved ProcyclicTrypanosoma bruceiRelies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux
- (2013) Stefan Allmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid synthesis in protozoan parasites: A comparison between kinetoplastids and apicomplexans
- (2013) Srinivasan Ramakrishnan et al. PROGRESS IN LIPID RESEARCH
- Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry
- (2012) Kapila Gunasekera et al. BMC GENOMICS
- Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei
- (2012) Guiomar Pérez-Moreno et al. INTERNATIONAL JOURNAL FOR PARASITOLOGY
- ATP Synthesis-coupled and -uncoupled Acetate Production from Acetyl-CoA by Mitochondrial Acetate:Succinate CoA-transferase and Acetyl-CoA Thioesterase inTrypanosoma
- (2012) Yoann Millerioux et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2012) Victoria Lucia Alonso et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Mitochondrial Outer Membrane Proteome ofTrypanosoma bruceiReveals Novel Factors Required to Maintain Mitochondrial Morphology
- (2012) Moritz Niemann et al. MOLECULAR & CELLULAR PROTEOMICS
- Estimating and Mapping the Population at Risk of Sleeping Sickness
- (2012) Pere P. Simarro et al. PLoS Neglected Tropical Diseases
- Novel sterol metabolic network ofTrypanosoma bruceiprocyclic and bloodstream forms
- (2011) Craigen R. Nes et al. BIOCHEMICAL JOURNAL
- Multiple roles of proline transport and metabolism in trypanosomatids
- (2011) Frederic Bringaud Frontiers in Bioscience-Landmark
- The characterization and evolutionary relationships of a trypanosomal thiolase
- (2011) Muriel Mazet et al. INTERNATIONAL JOURNAL FOR PARASITOLOGY
- Metabolomic analysis of trypanosomatid protozoa
- (2011) Darren J. Creek et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Requirement for acetyl-CoA carboxylase in Trypanosoma brucei is dependent upon the growth environment
- (2011) Patrick A. Vigueira et al. MOLECULAR MICROBIOLOGY
- Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle
- (2010) Brice Rotureau et al. CELLULAR MICROBIOLOGY
- Ablation of Succinate Production from Glucose Metabolism in the Procyclic Trypanosomes Induces Metabolic Switches to the Glycerol 3-Phosphate/Dihydroxyacetone Phosphate Shuttle and to Proline Metabolism
- (2010) Charles Ebikeme et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid metabolism in Trypanosoma brucei
- (2010) Terry K. Smith et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- The Trypanosoma brucei MitoCarta and its regulation and splicing pattern during development
- (2010) Xiaobai Zhang et al. NUCLEIC ACIDS RESEARCH
- Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
- (2010) Q. Wang et al. SCIENCE
- Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes
- (2009) L. Riviere et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The 3-hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis inTrypanosoma brucei
- (2008) Kaija J. Autio et al. FEBS LETTERS
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- (2008) Aswini K. Panigrahi et al. PROTEOMICS
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