Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation

Structural Mimicry by a Bacterial F Box Effector Hijacks the Host Ubiquitin-Proteasome System

(2017) Kathy Wong et al.   STRUCTURE

Legionella Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner

(2017) Samual C. Allgood et al.   Frontiers in Cellular and Infection Microbiology

Unraveling the Phosphocholination Mechanism of the Legionella pneumophila Enzyme AnkX

(2016) Konstantin Gavriljuk et al.   BIOCHEMISTRY

Endemic Scrub Typhus in South America

(2016) Thomas Weitzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Importins and exportins as therapeutic targets in cancer

(2016) Amit Mahipal et al.   PHARMACOLOGY & THERAPEUTICS

An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

(2016) Lynn Soong et al.   PLoS Neglected Tropical Diseases

Inhibition of Nuclear Transport of NF-ĸB p65 by the Salmonella Type III Secretion System Effector SpvD

(2016) Nathalie Rolhion et al.   PLoS Pathogens

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells

(2016) Laura Berneking et al.   PLoS Pathogens

Chromatin-bound bacterial effector ankyrin A recruits histone deacetylase 1 and modifies host gene expression

(2015) Kristen E. Rennoll-Bankert et al.   CELLULAR MICROBIOLOGY

Orientia tsutsugamushi Strain Ikeda Ankyrin Repeat-Containing Proteins Recruit SCF1 Ubiquitin Ligase Machinery via Poxvirus-Like F-Box Motifs

(2015) Andrea R. Beyer et al.   JOURNAL OF BACTERIOLOGY

Improved Quantification, Propagation, Purification and Storage of the Obligate Intracellular Human Pathogen Orientia tsutsugamushi

(2015) Suparat Giengkam et al.   PLoS Neglected Tropical Diseases

A Systematic Review of Mortality from Untreated Scrub Typhus (Orientia tsutsugamushi)

(2015) Andrew J. Taylor et al.   PLoS Neglected Tropical Diseases

A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

(2014) Min Lu et al.   CELL

Significantly Higher Cytokine and Chemokine Levels in Patients with Japanese Spotted Fever than in Those with Tsutsugamushi Disease

(2014) K. Tai et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Chlorovirus Skp1-Binding Ankyrin Repeat Protein Interplay and Mimicry of Cellular Ubiquitin Ligase Machinery

(2014) E. A. Noel et al.   JOURNAL OF VIROLOGY

Multiple Orientia tsutsugamushi Ankyrin Repeat Proteins Interact with SCF1 Ubiquitin Ligase Complex and Eukaryotic Elongation Factor 1 α

(2014) Chan-Ki Min et al.   PLoS One

Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB

(2014) Kristin Burles et al.   VIROLOGY

Strong Type 1, but Impaired Type 2, Immune Responses Contribute to Orientia tsutsugamushi-Induced Pathology in Mice

(2014) Lynn Soong et al.   PLoS Neglected Tropical Diseases

Dissemination of Orientia tsutsugamushi and Inflammatory Responses in a Murine Model of Scrub Typhus

(2014) Christian A. Keller et al.   PLoS Neglected Tropical Diseases

Ankyrin domains across the Tree of Life

(2014) Kristin K. Jernigan et al.   PeerJ

Genetic Screen of a Mutant Poxvirus Library Identifies an Ankyrin Repeat Protein Involved in Blocking Induction of Avian Type I Interferon

(2013) S. M. Laidlaw et al.   JOURNAL OF VIROLOGY

Monoubiquitination of nuclear RelA negatively regulates NF-κB activity independent of proteasomal degradation

(2012) Karin Hochrainer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Orientia tsutsugamushi, the causative agent of scrub typhus, induces an inflammatory program in human macrophages

(2012) Wiwit Tantibhedhyangkul et al.   MICROBIAL PATHOGENESIS

Intracellular Invasion of Orientia tsutsugamushi Activates Inflammasome in ASC-Dependent Manner

(2012) Jung-Eun Koo et al.   PLoS One

Orientia tsutsugamushi in Human Scrub Typhus Eschars Shows Tropism for Dendritic Cells and Monocytes Rather than Endothelium

(2012) Daniel H. Paris et al.   PLoS Neglected Tropical Diseases

Kinetics and Magnitude of Antibody Responses against the Conserved 47-Kilodalton Antigen and the Variable 56-Kilodalton Antigen in Scrub Typhus Patients

(2011) Hua-Wei Chen et al.   Clinical and Vaccine Immunology

Involvement of Ca2+ signaling in intracellular invasion of non-phagocytic host cells by Orientia tsutsugamushi

(2011) Youngho Ko et al.   MICROBIAL PATHOGENESIS

Modulation of NF-κB signalling by microbial pathogens

(2011) Masmudur M. Rahman et al.   NATURE REVIEWS MICROBIOLOGY

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

(2010) Martin Hintersteiner et al.   ACS Chemical Biology

The importin β binding domain as a master regulator of nucleocytoplasmic transport

(2010) Kaylen Lott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Indispensable Role for the Eukaryotic-Like Ankyrin Domains of the Ankyrin B Effector of Legionella pneumophila within Macrophages and Amoebae

(2010) C. T. D. Price et al.   INFECTION AND IMMUNITY

E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates

(2010) A. W. Ensminger et al.   INFECTION AND IMMUNITY

Isolation of a NovelOrientiaSpecies (O. chutosp. nov.) from a Patient Infected in Dubai

(2010) Leonard Izzard et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Scrub Typhus: The Geographic Distribution of Phenotypic and Genotypic Variants ofOrientia tsutsugamushi

(2009) Daryl J. Kelly et al.   CLINICAL INFECTIOUS DISEASES

Correlation between the concentrations of tumor necrosis factor-α and the severity of disease in patients infected with Orientia tsutsugamushi

(2009) Hiromichi Iwasaki et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Mitogen-activated protein kinases are involved in tumor necrosis factor alpha production in macrophages infected withOrientia tsutsugamushi

(2009) Ji-Hyun Yun et al.   MICROBIOLOGY AND IMMUNOLOGY

Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

EXPORTIN 1 INHIBITION ATTENUATES NUCLEAR FACTOR-κB-DEPENDENT GENE EXPRESSION

(2009) Mark D. Walsh et al.   SHOCK

The Whole-genome Sequencing of the Obligate Intracellular Bacterium Orientia tsutsugamushi Revealed Massive Gene Amplification During Reductive Genome Evolution

(2008) K. Nakayama et al.   DNA RESEARCH

Electron-microscopic observation of mouse spleen tissue infected with Orientia tsutsugamushi isolated from Shandong, China

(2008) L. Yang et al.   Microscopy

Hantaan Virus Nucleocapsid Protein Binds to Importin   Proteins and Inhibits Tumor Necrosis Factor Alpha-Induced Activation of Nuclear Factor Kappa B

(2008) S. L. Taylor et al.   JOURNAL OF VIROLOGY

Immunohistochemical Study of Scrub Typhus: A Report of Two Cases

(2008) Bo-Yuan Tseng et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes

(2008) S. Sonnberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors

(2008) X. Pan et al.   SCIENCE

Kinetics of inflammatory cytokines in patients with scrub typhus receiving doxycycline treatment

(2007) Doo Ryeon Chung et al.   JOURNAL OF INFECTION