Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

(2016) Fabrice E. Graf et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine–guanine phosphoribosyltransferase

(2016) David Terán et al.   Scientific Reports

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases

(2015) Dana Hocková et al.   BIOORGANIC & MEDICINAL CHEMISTRY

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

(2015) Wai Soon Eng et al.   JOURNAL OF MEDICINAL CHEMISTRY

GMP synthase is essential for viability and infectivity ofTrypanosoma bruceidespite a redundant purine salvage pathway

(2015) Qiong Li et al.   MOLECULAR MICROBIOLOGY

Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis

(2014) Advait S. Nagle et al.   CHEMICAL REVIEWS

Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents

(2014) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

The diverse pharmacology and medicinal chemistry of phosphoramidates – a review

(2014) Fabrício M. Oliveira et al.   RSC Advances

Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

(2013) Darren J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of the Escherichia coli 6-Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

(2013) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group Are Potent Inhibitors of 6-Oxopurine Phosphoribosyltransferases and Have Antimalarial Activity

(2013) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

(2013) Binny M. Mony et al.   NATURE

Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase

(2012) Keith Z. Hazleton et al.   CHEMISTRY & BIOLOGY

Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

(2012) Dana Hocková et al.   JOURNAL OF MEDICINAL CHEMISTRY

Purine salvage in Leishmania: complex or simple by design?

(2012) Jan M. Boitz et al.   TRENDS IN PARASITOLOGY

Estimating and Mapping the Population at Risk of Sleeping Sickness

(2012) Pere P. Simarro et al.   PLoS Neglected Tropical Diseases

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

(2011) Marcela Krečmerová et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine–guanine–(xanthine) phosphoribosyltransferases

(2011) Michal Česnek et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Purine Salvage Pathway in Mycobacterium tuberculosis

(2011) R. G. Ducati et al.   CURRENT MEDICINAL CHEMISTRY

6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs

(2011) John de Jersey et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Drug resistance in human African trypanosomiasis

(2011) Michael P Barrett et al.   Future Microbiology

The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

(2011) Pere P. Simarro et al.   PLoS Neglected Tropical Diseases

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

(2010) M. Berg et al.   CURRENT MEDICINAL CHEMISTRY

A Novel Protein Kinase Localized to Lipid Droplets Is Required for Droplet Biogenesis in Trypanosomes

(2010) John A. Flaspohler et al.   EUKARYOTIC CELL

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy

(2010) Dianne T. Keough et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics

(2009) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase

(2002) Luke W. Guddat et al.   PROTEIN SCIENCE