Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane

Pib2 and the EGO complex are both required for activation of TORC1

(2017) Natalia V. Varlakhanova et al.   JOURNAL OF CELL SCIENCE

An In Vitro TORC1 Kinase Assay That Recapitulates the Gtr-Independent Glutamine-Responsive TORC1 Activation Mechanism on Yeast Vacuoles

(2017) Mirai Tanigawa et al.   MOLECULAR AND CELLULAR BIOLOGY

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

(2017) Manoël Prouteau et al.   NATURE

Functional mapping of yeast genomes by saturated transposition

(2017) Agnès H Michel et al.   eLife

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae

(2016) Seda Yerlikaya et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2

(2016) Shintaro Kira et al.   MOLECULAR BIOLOGY OF THE CELL

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

(2016) Mee-Sup Yoon et al.   Cell Reports

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

(2015) Katie Powis et al.   CELL RESEARCH

The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity

(2015) Feike Hao et al.   FEBS LETTERS

A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress

(2015) Adam Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Fast protein-depletion system utilizing tetracycline repressible promoter and N-end rule in yeast

(2015) Sivakumar Vadivel Gnanasundram et al.   MOLECULAR BIOLOGY OF THE CELL

Inferring causal metabolic signals that regulate the dynamic TORC1-dependent transcriptome

(2015) A. P. Oliveira et al.   Molecular Systems Biology

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

(2015) Marie-Pierre Péli-Gulli et al.   Cell Reports

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

(2014) Shintaro Kira et al.   Autophagy

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

(2014) Daniele Stracka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity

(2013) Yasuhiro Araki et al.   JOURNAL OF CELL BIOLOGY

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

(2010) A. Breitkreutz et al.   SCIENCE

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae

(2009) M. G. Banuelos et al.   CURRENT GENETICS

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An in Vivo Map of the Yeast Protein Interactome

(2008) K. Tarassov et al.   SCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE