Th-POK regulates mammary gland lactation through mTOR-SREBP pathway

Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis

(2017) Siming Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

mTOR signaling in cellular and organismal energetics

(2015) Verena Albert et al.   CURRENT OPINION IN CELL BIOLOGY

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

(2015) Nai Yang Fu et al.   NATURE CELL BIOLOGY

Identification of multipotent mammary stem cells by protein C receptor expression

(2014) Daisong Wang et al.   NATURE

The transcription factor ThPOK suppresses Runx3 and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling

(2014) Megan A Luckey et al.   NATURE IMMUNOLOGY

Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland

(2014) J M Cunnick et al.   ONCOGENE

Differential requirement of GRP94 and GRP78 in mammary gland development

(2014) Genyuan Zhu et al.   Scientific Reports

The insulin receptor plays an important role in secretory differentiation in the mammary gland

(2013) Margaret C. Neville et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis

(2012) Tong-Fei Liu et al.   Cell Metabolism

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

Epigenetic Silencing of Cd8 Genes by ThPOK-Mediated Deacetylation during CD4 T Cell Differentiation

(2012) J. Rui et al.   JOURNAL OF IMMUNOLOGY

Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids

(2012) Wenshan Wang et al.   NATURE MEDICINE

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammary gland development

(2012) Hector Macias et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell

(2011) Michael C. Rudolph et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Determinants of adipophilin function in milk lipid formation and secretion

(2011) Brandi M. Chong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium

(2010) Michael C. Rudolph et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of ThPOK in Control of CD4/CD8 Lineage Commitment

(2010) Xi He et al.   Annual Review of Immunology

The network of transcription factors that underlie the CD4 versus CD8 lineage decision

(2010) T. Naito et al.   INTERNATIONAL IMMUNOLOGY

p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor

(2010) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

Immune Cell Location and Function During Post-Natal Mammary Gland Development

(2010) Johanna R. Reed et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

(2010) Y. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukocytes in Mammary Development and Cancer

(2010) L. M. Coussens et al.   Cold Spring Harbor Perspectives in Biology

Lactation failure in Src knockout mice is due to impaired secretory activation

(2008) Harriet Watkin et al.   BMC DEVELOPMENTAL BIOLOGY

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Cell Growth Control: mTOR Takes on Fat

(2008) Ted Powers   MOLECULAR CELL

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells

(2008) Lie Wang et al.   NATURE IMMUNOLOGY

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development

(2008) R. Setoguchi et al.   SCIENCE