Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis

EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex

(2017) Suzanne N. Shapira et al.   GENES & DEVELOPMENT

Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation

(2017) Lin Mi et al.   Molecular Metabolism

βlinc1encodes a long noncoding RNA that regulates islet β-cell formation and function

(2016) Luis Arnes et al.   GENES & DEVELOPMENT

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

(2016) Tamer Sallam et al.   NATURE

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Brown adipose tissue as a secretory organ

(2016) Francesc Villarroya et al.   Nature Reviews Endocrinology

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

(2016) Daniel C. Berry et al.   Nature Communications

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

(2015) Raymond E. Soccio et al.   CELL

A Liver-Enriched Long Non-Coding RNA, lncLSTR, Regulates Systemic Lipid Metabolism in Mice

(2015) Ping Li et al.   Cell Metabolism

De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development

(2015) Juan R. Alvarez-Dominguez et al.   Cell Metabolism

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

(2015) Matthew J. Harms et al.   GENES & DEVELOPMENT

Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat

(2015) Jon Dempersmier et al.   MOLECULAR CELL

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

Long Noncoding RNAs: A New Regulatory Code in Metabolic Control

(2015) Xu-Yun Zhao et al.   TRENDS IN BIOCHEMICAL SCIENCES

The brown fat secretome: metabolic functions beyond thermogenesis

(2015) Guo-Xiao Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

(2014) Jang Hyun Choi et al.   GENES & DEVELOPMENT

A Long Noncoding RNA Transcriptional Regulatory Circuit Drives Thermogenic Adipocyte Differentiation

(2014) Xu-Yun Zhao et al.   MOLECULAR CELL

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

Brown fat fuel utilization and thermogenesis

(2014) Kristy L. Townsend et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

A Multifunctional Protein, EWS, Is Essential for Early Brown Fat Lineage Determination

(2013) Jun Hong Park et al.   DEVELOPMENTAL CELL

Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation

(2013) G.-X. Wang et al.   DIABETES

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

(2013) Haruya Ohno et al.   NATURE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Long noncoding RNAs regulate adipogenesis

(2013) Lei Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Exploring long non-coding RNAs through sequencing

(2011) Sophie R. Atkinson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Regulation of Hepatic ApoC3 Expression by PGC-1β Mediates Hypolipidemic Effect of Nicotinic Acid

(2010) Carlos Hernandez et al.   Cell Metabolism

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

Cellular bioenergetics as a target for obesity therapy

(2010) Yu-Hua Tseng et al.   NATURE REVIEWS DRUG DISCOVERY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide Coactivation Analysis of PGC-1α Identifies BAF60a as a Regulator of Hepatic Lipid Metabolism

(2008) Siming Li et al.   Cell Metabolism

CD4-CD8 Lineage Commitment Is Regulated by a Silencer Element at the ThPOK Transcription-Factor Locus

(2008) Xi He et al.   IMMUNITY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate

(2008) Sawako Muroi et al.   NATURE IMMUNOLOGY

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

(2008) Takeshi Egawa et al.   NATURE IMMUNOLOGY

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells

(2008) Lie Wang et al.   NATURE IMMUNOLOGY