The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice

(2016) Leesa L. Sampson et al.   FASEB JOURNAL

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

(2016) Shurong Hu et al.   PLoS One

Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice

(2016) Mi-Ja Jung et al.   Scientific Reports

Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease

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Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models

(2015) Yuting Guan et al.   JOURNAL OF IMMUNOLOGY

TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium

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The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children

(2014) Mohamed Mutalib et al.   Journal of Crohns & Colitis

Mouse and human Notch-1 regulate mucosal immune responses

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Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

(2014) Tae-Hee Kim et al.   NATURE

Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling

(2013) Jillian L Pope et al.   GUT

Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis

(2013) Hui Yin et al.   IMMUNOLOGY

The mTOR pathway and integrating immune regulation

(2013) Stephen P. Cobbold   IMMUNOLOGY

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α

(2013) Ken S. Lau et al.   Integrative Biology

Role of Janus Kinase 3 in Mucosal Differentiation and Predisposition to Colitis

(2013) Jayshree Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

Pharmacological Control of Autophagy: Therapeutic Perspectives in Inflammatory Bowel Disease and Colorectal Cancer

(2012) Sofia Garcia-Maurino et al.   CURRENT PHARMACEUTICAL DESIGN

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium

(2012) Ken S. Lau et al.   PLOS BIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Guidelines for the management of inflammatory bowel disease in adults

(2011) C. Mowat et al.   GUT

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

(2010) M. NIESSNER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice

(2010) Misumi Shinoda et al.   JOURNAL OF GASTROENTEROLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Intestinal epithelial cells in inflammatory bowel diseases

(2010) Giulia Roda   WORLD JOURNAL OF GASTROENTEROLOGY

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

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A Multicenter, Randomized, Double-Blind Trial of EverolimusVersusAzathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

(2008) Walter Reinisch et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A novel mTOR inhibitor is efficacious in a murine model of colitis

(2008) Mandar R. Bhonde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Diverse Adult Stem Cells Share Specific Higher-Order Patterns of Gene Expression

(2008) Jason M. Doherty et al.   STEM CELLS