Review
Biology
Dong-Ho Nahm
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by itching and eczematous lesions. Activation of regulatory T (Treg) cells can provide long-term improvement and induce immune tolerance in AD.
Article
Allergy
Veronique Bajzik, Hannah A. DeBerg, Nahir Garabatos, Blake J. Rust, Kimberly K. Obrien, Quynh-Anh Nguyen, Colin O'Rourke, Alex Smith, Alex H. Walker, Charlie Quinn, Vivian H. Gersuk, Mary Farrington, David Jeong, Brian P. Vickery, Daniel C. Adelman, Erik Wambre
Summary: By studying individuals with peanut allergy undergoing oral desensitization immunotherapy, researchers found that this treatment reduces allergic reactions to peanuts and reshapes T-cell responses to peanuts.
Article
Oncology
Audrey Moatti, Anais Debesset, Caroline Pilon, Asma Beldi-Ferchiou, Mathieu Leclerc, Rabah Redjoul, Frederic Charlotte, Nhu Hanh To, Adeline Bak, Yazid Belkacemi, Benoit Laurent Salomon, Fadi Issa, David Michonneau, Sebastien Maury, Jose Laurent Cohen, Allan Thiolat
Summary: This study reveals the potential of targeting TNFR2 to enhance anti-tumor responses and treat relapse of blood malignancies. The researchers also found that TNFR2 is over-expressed in Tregs from healthy donors and patients with leukemia relapse or GVHD. These findings provide new perspectives for the development of immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Nobuhiko Imahashi, Rafet Basar, Yuefan Huang, Fang Wang, Natalia Baran, Pinaki Prosad Banerjee, Junjun Lu, Ana Karen Nunez Cortes, Nadima Uprety, Emily Ensley, Luis Muniz-Feliciano, Tamara J. Laskowski, Judy S. Moyes, May Daher, Mayela Mendt, Lucila N. Kerbauy, Mayra Shanley, Li Li, Francesca Lorraine Wei Inng Lim, Hila Shaim, Ye Li, Marina Konopleva, Michael Green, Jennifer Wargo, Elizabeth J. Shpall, Ken Chen, Katayoun Rezvani
Summary: This study shows that activated B cells suppress T-cell responses through metabolic competition, including increased oxygen consumption and glucose deprivation. These findings provide new insights into immunometabolism and its potential implications for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Chenkai Mao, Veronique Beiss, Gregory W. Ho, Jennifer Fields, Nicole F. Steinmetz, Steven Fiering
Summary: This study discovered that ISV with CPMV induces systemic antitumor T-cell-mediated immunity that inhibits growth of untreated tumors and requires conventional type-1 dendritic cells (cDC1s). Furthermore, it was found that combining CPMV with local activation of antigen-presenting cells can enhance antitumor efficacy, induce an influx of CD8(+) T cells, trigger regression in both treated local and untreated distant tumors, and potentiate tumor responses to anti-PD-1 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Mizuki Yamada, Kohei Matsuoka, Mitsuo Sato, Kazuhide Sato
Summary: Current immunotherapies aim to modulate immune reactions, but often cause overactivation or over-suppression of the immune system. Near-infrared photoimmunotherapy (NIR-PIT) is a new modality that combines antibodies and a photoabsorber for cancer treatment. It can also be used to locally eliminate immune cells with specific markers, offering potential for anti-allergic therapy. Technological advancements have enabled selective targeting of cells and tissues in the body, providing opportunities for local immunomodulation.
Review
Virology
Martyna Cieslik, Natalia Baginska, Ewa Jonczyk-Matysiak, Alicja Wegrzyn, Grzegorz Wegrzyn, Andrzej Gorski
Summary: Bacteriophages can limit bacterial growth and amplification, and also serve as modulators of mammalian immune responses, particularly temperate phages that influence processes such as phagocytosis of bacterial invaders and immune modulation of mammalian host cells.
Article
Oncology
Irina Khononov, Eyal Jacob, Ella Fremder, Nili Dahan, Michal Harel, Ziv Raviv, Boris Krastev, Yuval Shaked
Summary: ICI therapy triggers host-mediated biological processes that contribute to therapy resistance. Identification and analysis of such processes may lead to the discovery of biomarkers for clinical response and strategies for overcoming therapy resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yan Luo, Barath Shreeder, James W. Jenkins, Huashan Shi, Purushottam Lamichhane, Kexun Zhou, Deborah A. Bahr, Sophia Kurian, Katherine A. Jones, Joshua Daum, Navnita Dutta, Brian M. Necela, Martin J. Cannon, Matthew S. Block, Keith L. Knutson
Summary: This study found that Th17-DC vaccines can increase the number of Th17 T cells in the tumor microenvironment, reshape the myeloid microenvironment, and improve mouse survival. The efficacy of Th17-DC vaccines in OC is mediated by CD4 T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Simone M. Hayen, Andre C. Knulst, Johan Garssen, Henny G. Otten, Linette E. M. Willemsen
Summary: This study investigated the effect of FF on DC maturation and allergen presentation, showing that FF can increase the secretion of IL-10 and IP-10 in mature DCs, promoting T cell polarization and proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Meghan E. Sise, Qiyu Wang, Harish Seethapathy, Daiana Moreno, Destiny Harden, R. Neal Smith, Ivy A. Rosales, Robert B. Colvin, Sarah Chute, Lynn D. Cornell, Sandra M. Herrmann, Riley Fadden, Ryan J. Sullivan, Nancy J. Yang, Sara Barmettler, Sophia Wells, Shruti Gupta, Alexandra-Chloe Villani, Kerry L. Reynolds, Jocelyn Farmer
Summary: Non-invasive biomarkers such as elevated sIL-2R level and flow cytometric markers of B and T cell dysregulation may aid in the diagnosis of immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Antonio Sorrentino, Ayse Nur Menevse, Tillmann Michels, Valentina Volpin, Franziska Christine Durst, Julian Sax, Maria Xydia, Abir Hussein, Slava Stamova, Steffen Spoerl, Nicole Heuschneider, Jasmin Muehlbauer, Katharina Marlene Jeltsch, Anchana Rathinasamy, Melanie Werner-Klein, Marco Breinig, Damian Mikietyn, Christian Kohler, Isabel Poschke, Sabrina Purr, Olivia Reidell, Catarina Martins Freire, Rienk Offringa, Claudia Gebhard, Rainer Spang, Michael Rehli, Michael Boutros, Christian Schmidl, Nisit Khandelwal, Philipp Beckhove
Summary: This study reveals a molecular mechanism that protects tumor cells from cytotoxic T-cell attack and demonstrates the feasibility of pharmacological inhibition of this pathway.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Kazuki Nagashima, Aishan Zhao, Katayoon Atabakhsh, Minwoo Bae, Jamie E. Blum, Allison Weakley, Sunit Jain, Xiandong Meng, Alice G. Cheng, Min Wang, Steven Higginbottom, Alex Dimas, Pallavi Murugkar, Elizabeth S. Sattely, James J. Moon, Emily P. Balskus, Michael A. Fischbach
Summary: Certain bacterial strains from the microbiome induce a potent T cell response, and many T cells in the gut repertoire recognize multiple bacterial strains. 13 T cell clones show a one-to-many TCR-to-strain relationship, recognizing 18 Firmicutes strains.
Review
Immunology
Isis Benoit-Lizon, Lionel Apetoh
Summary: CD4 T cell effector subsets have a significant impact on cancer progression and the efficacy of immune checkpoint inhibitors. T(H)9 cells have shown superior antimelanoma activity, but further research is needed to understand their mechanisms and potential in treating other types of cancer.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel Ovidiu Costea
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel-Ovidiu Costea
Summary: Gut microbes play a crucial role in bariatric surgery outcomes, as they can be altered by the surgery and have beneficial effects on therapeutic results.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Boukelia Boukhmis, Geir Bjorklund, Ibrahim H. Elkhidir, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Adekunle Hakeem Temitope, Sadaf Noor, Daniel-Ovidiu Costea
Summary: This systematic review and meta-analysis examined the effect of physical activity on weight loss in adults who underwent bariatric surgery. The study also compared biomarkers between individuals with different levels of physical activity after surgery. The results showed that BMI as a measure of physical activity had a positive impact on the target population. However, further larger-scale studies with stricter criteria are needed to confirm these findings.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Letter
Medicine, General & Internal
Salvatore Chirumbolo, Luigi Valdenassi, Vincenzo Simonetti, Sergio Pandolfi
INTERNAL AND EMERGENCY MEDICINE
(2023)
Letter
Virology
Salvatore Chirumbolo
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Neurosciences
Nagwa A. Meguid, Heba S. Hashem, Mohamed H. Ghanem, Samia A. Helal, Yuliya Semenova, Saher Hashem, Adel Hashish, Salvatore Chirumbolo, Ahmed M. Elwan, Geir Bjorklund
Summary: This study aimed to identify metabolic abnormalities in BCAAs and investigate the presence of epileptiform discharges in ASD patients. Results showed that various types of seizures can occur in ASD children and that ASD children have lower levels of BCAAs compared to neurotypical controls. Further research is needed to better understand ASD and evaluate the association between ASD, EEG changes, seizures, and BCAAs more reliably.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Review
Infectious Diseases
Yernar Amangelsin, Yuliya Semenova, Maryam Dadar, Mohamad Aljofan, Geir Bjorklund
Summary: Tetracycline, a widely used antibiotic, has become a serious threat to the environment due to overuse and weak degradation ability. It accumulates in the food chain, causing toxicity to microbial communities, promoting antibiotic resistance, and disrupting human intestinal flora.
Review
Chemistry, Medicinal
Amin Gasmi, Mariia Shanaida, Oleksandra Oleshchuk, Yuliya Semenova, Pavan Kumar Mujawdiya, Yana Ivankiv, Olena Pokryshko, Sadaf Noor, Salva Piscopo, Stepan Adamiv, Geir Bjorklund
Summary: The immune system protects the body from infectious agents, and a well-balanced immunity is crucial for maintaining human health. Nutritional and micronutrient deficiencies can compromise the immune system, while certain bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources have shown immunomodulatory properties and can enhance the immune response.
Review
Health Care Sciences & Services
Laura Kassym, Assiya Kussainova, Yuliya Semenova, Almas Kussainov, Damir Marapov, Marat Zhanaspayev, Zhanar Urazalina, Almira Akhmetova, Madi Tokanov, Yerbol Smail, Geir Bjorklund
Summary: Drunk driving is a significant risk factor for traffic accidents and their lethality. This meta-analysis provides estimates of the prevalence of drunk driving in non-lethally injured drivers, considering factors such as the world region, blood alcohol concentration, and study quality. The pooled prevalence of drunk driving in injured drivers was found to be 16.6%.
Letter
Pharmacology & Pharmacy
Salvatore Chirumbolo
Letter
Psychiatry
Salvatore Chirumbolo
PSYCHIATRY RESEARCH
(2023)
Letter
Medicine, General & Internal
Salvatore Chirumbolo, Luigi Valdenassi, Marianno Franzini
CLINICAL CASE REPORTS
(2023)
Letter
Geriatrics & Gerontology
Salvatore Chirumbolo
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)