Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines

(2017) Amanda L. Woerman et al.   JAMA Neurology

Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy

(2016) Francesco Panza et al.   Immunotherapy

Active Vaccines for Alzheimer Disease Treatment

(2016) Rosalie M. Sterner et al.   Journal of the American Medical Directors Association

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

(2016) Seung-Hye Lee et al.   Cell Reports

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

(2016) Andrea Wolf et al.   PLoS One

Immunotherapeutic Approaches for Alzheimer’s Disease

(2015) Thomas Wisniewski et al.   NEURON

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

T-cell epitope-dependent immune response in inbred (C57BL/6J, SJL/J, and C3H/HeN) and transgenic P301S and Tg2576 mice

(2013) Monique Richter et al.   JOURNAL OF PEPTIDE SCIENCE

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

A VLP Library of C-Terminally Truncated Hepatitis B Core Proteins: Correlation of RNA Encapsidation with a Th1/Th2 Switch in the Immune Responses of Mice

(2013) Irina Sominskaya et al.   PLoS One

Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach

(2012) Nadege Zommer et al.   Current Alzheimer Research

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded Truncated Protein   Induces Innate Immune Response via MAPK Pathway

(2011) A. Kovac et al.   JOURNAL OF IMMUNOLOGY

The Second-Generation Active A  Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects

(2011) C. Wiessner et al.   JOURNAL OF NEUROSCIENCE

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

(2011) Mian Bi et al.   PLoS One

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

(2010) A. Boutajangout et al.   JOURNAL OF NEUROSCIENCE

Transition of Tau Protein from Disordered to Misordered in Alzheimer’s Disease

(2010) Branislav Kovacech et al.   Neurodegenerative Diseases

Immunotherapy and neuroimmunology in Alzheimer’s disease: a perspective from the blood–brain barrier

(2009) William A Banks   Immunotherapy

Melanoma vaccine candidates from chimeric hepatitis B core virus-like particles carrying a tumor-associated MAGE-3 epitope

(2008) Andris Kazaks et al.   Biotechnology Journal

Progress in the Active Immunotherapeutic Approach to Alzheimer’s Disease: Clinical Investigations into AN1792-Associated Meningoencephalitis

(2008) Michael Pride et al.   Neurodegenerative Diseases

Analysis of Tau Phosphorylation and Truncation in a Mouse Model of Human Tauopathy

(2007) Patrice Delobel et al.   AMERICAN JOURNAL OF PATHOLOGY