Article
Engineering, Environmental
Xiang-Ping Zhang, Kai-Yuan Huang, Shao-Bin He, Hua-Ping Peng, Xing-Hua Xia, Wei Chen, Hao-Hua Deng
Summary: A fluorescent sensor array based on a gold nanocluster probe was developed for the rapid discrimination of heavy metal ions by changing the pH value, successfully identifying seven HMIs with 100% accuracy. This study provides a simple yet powerful sensing platform for multiple HMIs and shows broad application prospects in environmental monitoring.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Mengjiao Mo, Haoyi Yuan, Jingyu Zhang, Jian Wang, Ying Liu, Juanjuan Peng, Lingzhi Zhao
Summary: Antibiotic contamination is a global problem due to abuse and misuse, and an efficient detection method is needed. This study synthesized fluorescent gold nanoclusters with ligands and used rare earth ions to enhance their fluorescence. The sensor array developed based on this mechanism successfully detected and discriminated six different antibiotics, showing high selectivity and anti-interference performance. The sensor array also demonstrated potential applications in quantitation and blind sample recognition.
Article
Chemistry, Multidisciplinary
Parimah Aminfar, Goonay Yousefalizadeh, Emily Steele, Juan Chen, Gang Zheng, Kevin G. Stamplecoskie
Summary: Aqueous gold nanoclusters (AuNCs) have potential applications in biomedical imaging and therapy due to their unique electronic structures. However, their optical impurity and polydispersity pose challenges for isolation of the most stable structure and potential clinical applications. This study reports optically pure Au16L14 clusters, assessed by fluorescence excitation-emission matrix (EEM) spectroscopy and parallel factor (PARAFAC) analysis. The reactivity of the excited state with molecular oxygen was also investigated, showing that Au16L14 clusters generate type I reactive oxygen species (ROS), making them effective sensitizers for photodynamic therapy.
Article
Environmental Sciences
Wei-Bin Tseng, Jui-Yeh Rau, Hung-Chi Chiou, Wei-Lung Tseng
Summary: This study developed a straightforward strategy to prepare lysozyme nanoparticle-encapsulated gold nanoclusters (LysNP-AuNCs) as a dual-emission probe for the ratiometric sensing of cyanide through fluorescence resonance energy transfer (FRET) without the conjugation of additional fluorophores. The LysNP-AuNC probe showed high selectivity for cyanide and was able to detect cyanide in tap water, soils, and cyanogenic glycoside-containing foods.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Lu Ding, Yanyu Zhao, Huihui Li, Qiujuan Zhang, Weiting Yang, Bo Fu, Qinhe Pan
Summary: Fluorescent probes with in-situ visual feature have gained attention for detecting doxycycline (DC), a widely used tetracycline antibiotic in animal husbandry. Bovine serum albumin-capped gold nanoclusters (BSA-AuNCs) were used as a ratiometric fluorescent probe to selectively detect DC among tetracycline antibiotics. BSA-AuNCs showed the highest response toward DC, with simple synthesis, short response time (1 min), and low detection limit. This work proposes an efficient strategy for designing fluorescent probes to selectively detect DC among tetracycline antibiotics.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Meng-Xian Liu, Xiao-Bing Chen, Wen-Ye Liu, Guang-Yue Zou, Yong-Liang Yu, Shuai Chen, Jian-Hua Wang
Summary: In this study, bifunctional carbon dots that can target and reflect the lipid composition in lipid droplets (LDs) were synthesized. These carbon dots showed highly sensitive fluorescence signals in response to lipid composition changes in LDs. The capacity of cells to generate and maintain LD subgroups with varying lipid composition was revealed by microscopic imaging and mathematical modeling. Furthermore, LDs with characteristic lipid compositions were observed around mitochondria in oxidative stress cells, and the proportion of LD subgroups changed and gradually disappeared with oxidative stress therapeutics. These carbon dots have great potential for investigating LD subgroups and metabolic regulations in situ.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yu Xu, Cheng Qian, Yang Yu, Shijie Yang, Fangfang Shi, Xu Gao, Yuhang Liu, Hui Huang, Callum Stewart, Fei Li, Jinsong Han
Summary: Array-based sensing methods with a fluorescent sensor array that combines nanoenzymes and bioenzymes have been developed for the detection of amyloids, allowing for the accurate diagnosis of early-stage Alzheimer's disease. Through the use of machine learning algorithms, a simplified sensor array is created, which can amplify the signals and achieve 100% accuracy in discriminating the aggregation species and kinetics at a concentration of 200 nM. Additionally, the sensor array can also differentiate between AD model mice and healthy mice with 100% accuracy, providing a powerful tool for diagnosing AD.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Kaiyuan Zheng, Magdiel I. Setyawati, David Tai Leong, Jianping Xie
Summary: The study utilized luminescent gold NCs as traceable antimicrobial agents to demonstrate their interaction with bacteria, revealing a mechanism where the NCs accumulate inside bacteria and induce reactive oxygen species generation.
Article
Materials Science, Multidisciplinary
Chun-Lin Lv, Chen-Huai Yang, Li-Ya Liu, Zhi-Cheng Zhang
Summary: The post-functionalization of gold nanoclusters with organic molecules is an efficient approach to develop multifunctional materials. Two novel organoimido functionalized trinuclear gold nanoclusters have been successfully obtained, and their photoluminescence properties have been investigated.
Article
Chemistry, Analytical
Jia An, Rubing Chen, Meizhu Chen, Yongqin Hu, Ying Lyu, Yufei Liu
Summary: Ratiometric fluorescent probes constructed in this study showed high accuracy and sensitivity for the detection of Ag+. The fluorescence color of the probes changes as the concentration of Ag+ increases. These probes have the potential to be applied in environmental monitoring and food safety assessment, with the ability for visual detection of Ag+.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Ditta Ungor, Anna Barbasz, Agnieszka Czyzowska, Edit Csapo, Magdalena Ocwieja
Summary: This study focused on the comparative cytotoxicity investigations of protein-stabilized gold nanoclusters on lymphocytes B and T cells. It was found that gamma G-Au NCs induced the highest disorders in mitochondrial activity, while LYZ- and gamma G-Au NCs enhanced the secretion of malonic dialdehyde. Despite minor effects on cell viability, all Au NCs caused oxidative stress and could stimulate undesirable cellular processes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Spectroscopy
Chen -Ting Zhu, Kai -Yuan Huang, Qing-Lin Zhou, Xiang -Ping Zhang, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen, Hamada A. A. Noreldeen
Summary: Sulfonamides are widely used but their accumulation in the human body can cause serious diseases. Therefore, a convenient, effective, and sensitive method to detect them is needed. In this study, a sensor array using BSA-AuNCs was constructed to detect five Sulfonamides, and the changes in fluorescence intensity at different excitation wavelengths were used for identification. This method shows great potential in the fields of food and drug monitoring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Applied
Yahui Guo, Helena T. N. N. Amunyela, Yuliang Cheng, Yunfei Xie, Hang Yu, Weirong Yao, Hung-Wing Li, He Qian
Summary: Metal nanoclusters, especially protein-templated gold nanoclusters, have attracted significant interest for their unique properties and potential applications. Natural proteins serve as ideal templates for the synthesis of these nanoclusters, allowing for exploration of their properties and applications in various fields.
Review
Engineering, Multidisciplinary
Ze Yan, Yi Cai, Jing Zhang, Yong Zhao
Summary: The fluorescent sensor array is an emerging method for metal ions detection, with advantages such as excellent sensitivity and high-throughput analysis, capable of simultaneously detecting multiple metal ions. This technology has made progress in recent years, significantly impacting the detection scope and accuracy of metal ions.
Review
Chemistry, Analytical
Changmao Yang, Houjin Zhang
Summary: Biosensors have limitations in detecting only one species of bacteria, but optical sensor arrays based on pattern recognition/machine learning algorithms have gained attention as a new type of biosensor. These sensor arrays can acquire multiple features of a target, forming a feature pattern, and determine the bacteria species.
Article
Chemistry, Physical
Fang Pu, Songrong Qu, Hao Qiu, Lu Zhang
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Hao Liu, Yawen You, Yanjuan Sang, Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: The study presents a microRNA-triggered nanozyme cascade platform for enhanced tumor-specific chemodynamic therapy, where the cascade reaction can be successfully triggered by high microRNA expression in cancer cells to generate more (OH)-O-. and demonstrate excellent tumor-specific therapeutic performance. This work provides a new dimension for tumor-specific chemodynamic therapy.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Haolu Hu, Xiaoxia Kang, Zhenhua Shan, Xiaoxiao Yang, Wei Bing, Li Wu, Haiyan Ge, Haiwei Ji
Summary: The construction of multifunctional nano-enzymes is a feasible strategy for fighting multi-drug resistant bacterial biofilm infections. We have developed a graphene oxide-based nano-enzyme platform that can effectively eradicate drug-resistant bacterial biofilm infections through the triple action of enzyme properties, photothermal therapy, and antimicrobial activity.
Article
Pharmacology & Pharmacy
Min Yang, Xiaohui Wang, Fang Pu, Ying Liu, Jia Guo, Shuzhuo Chang, Guoying Sun, Yinghua Peng
Summary: This study constructed a nanoplatform by rare earth elements and peptide modification, enhancing the effectiveness of exosomes in targeting tumor therapy, significantly improving the effects of imaging diagnosis and photothermal therapy. The platform could effectively accumulate at cancer sites, increasing the survival rate of mice.
Review
Chemistry, Inorganic & Nuclear
Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: Sensor arrays based on nucleic acids have great potential in detecting multiple targets. However, there is a lack of comprehensive reviews on sensor arrays from the perspective of nucleic acid as sensing elements.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Qu Tang, Xiaobo Zhou, JinXia Liu, Mingmin Wu, Haiwei Ji, Qi Wang, Guo Li, Hui Cong, Yuling Qin
Summary: The use of formic acid as an alternative fuel shows promise, but finding an efficient and low-cost solid catalyst for formic acid dehydrogenation at room temperature remains a challenge. Additionally, the lack of effective characterization techniques has limited the study of the kinetic mechanism of the dehydrogenation reaction.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Multidisciplinary Sciences
Yawen You, Qingqing Deng, Yibo Wang, Yanjuan Sang, Guangming Li, Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: This study reports on a DNA-based biocompatible, highly efficient, and precisely targeted copper nanocatalyst, which exhibits excellent catalytic activity and achieves efficient prodrug activation and antitumor effects in cancer cells.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Yawen You, Qingqing Deng, Yibo Wang, Yanjuan Sang, Guangming Li, Fang Pu, Jinsong Ren, Xiaogang Qu
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jiawei Zhu, Yawen You, Wenting Zhang, Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: In order to boost the endogenous Cu(I) level for intracellular drug synthesis through the bioorthogonal reaction, a self-adaptive bioorthogonal catalysis system was constructed by encapsulating prodrugs and sodium ascorbate within adenosine triphosphate aptamer-functionalized metal-organic framework nanoparticles. The system presents specificity to tumor cells and does not require exogenous Cu catalysts, thereby leading to high anti-tumor efficacy and minimal side effects both in vitro and in vivo. This work will open up a new opportunity for developing biosafe and high-performance bioorthogonal catalysis systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Guangming Li, Hao Liu, Jiadai Yi, Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: A versatile fiber-based compartmentalization strategy is developed to construct multi-nanozyme system capable of simultaneously performing incompatible reactions. Different microenvironments are tailored to each nanozyme, allowing them to exhibit their highest activity. This strategy has potential applications in disease treatment and biosensing.
Article
Chemistry, Multidisciplinary
Xiaobo Zhou, Lingfeng Zhao, Ke Zhang, Chaojie Yang, Shijie Li, Xiaoxia Kang, Guo Li, Qi Wang, Haiwei Ji, Mingmin Wu, Jinxia Liu, Yuling Qin, Li Wu
Summary: This study presented a strategy for designing and fabricating narrow emissive AIEdots with tunable wavelengths by constructing a light-harvesting system with high energy transfer efficiency, resulting in high brightness and narrow emission.
Article
Chemistry, Multidisciplinary
Minhao Jiang, Xiangyu Yan, Yibo Wang, Fang Pu, Huiling Liu, Yumei Li, Chunfeng Yang, Jiawei Zhu, Xuemeng Liu, Jinsong Ren, Xiaogang Qu
Summary: A one-component sensor array that mimics natural gustatory system is constructed for accurate and high-throughput discrimination and identification of versatile analytes. The system shows universality by rapidly and accurately discriminating metal ions, proteins, bacteria, and classifying antibiotic mechanisms. This study expands the application scope of HOFs and provides a facile and universal system for sensing applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Materials Science, Biomaterials
Linfeng Zhao, Can Zhao, Jiasheng Zhou, Haiwei Ji, Yuling Qin, Guo Li, Li Wu, Xiaobo Zhou
Summary: Accurate monitoring of biomolecular changes is crucial for disease diagnosis and treatment. Ratiometric fluorescence detection is a reliable method that can monitor different emission signals in multiple channels with built-in self-calibration. Conjugated polymers, as luminescent materials, have been widely used as ratiometric fluorescent probes in biosensing and bioimaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Yawen You, Hao Liu, Jiawei Zhu, Yibo Wang, Fang Pu, Jinsong Ren, Xiaogang Qu
Summary: This study developed a DNAzyme-augmented and targeted bioorthogonal catalyst that exhibits specificity to cancer cells and promotes the generation of Cu(i) for in situ drug synthesis. The DNAzyme also damages cancer cells, resulting in synergistic cancer therapy.
Article
Chemistry, Multidisciplinary
Xiang Ran, Zhenzhen Wang, Fang Pu, Enguo Ju, Jinsong Ren, Xiaogang Qu
Summary: A novel probe based on Au nanoclusters with aggregation-induced emission property was developed for sensitive telomerase detection in living cells and solid tumor tissue. This study provided insight into the specific connection mechanism of metal nanoclusters for AIE generation and shows great potential for disease detection both in vitro and in vivo.
MATERIALS HORIZONS
(2021)
